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CNS: Low Grade Glioma > Follow-up/Surveillance > Flashcards

Follow-up/Surveillance Flashcards

1
Q

How does RT affect QOL in the Tx of LGG?

A

QOL in LGG is impacted by Sg, RT, chemo, and seizure meds. Based on the EORTC 22844 dose-escalation study, higher-dose RT was significantly associated with fatigue/malaise and insomnia and ↓ emotional functioning. (Kiebert GM et al., Eur J Cancer 1998)

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2
Q

Does RT predispose LGG lesions to malignant transformation?

A

No. RT is not associated with an ↑ rate of malignant transformation. In EORTC 22845, there was a 70% transformation rate in both the adj and observation arms.

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3
Q

What is the NCCN recommended radiographic surveillance frequency for LGG post Tx?

A

The recommended imaging frequency post Tx is MRI q3–6mos for 1st 5 yrs, then annually. (NCCN 2018) Chiasm is commonly constrained to 54 Gy in 1.8–2 Gy/fx and 8 Gy in a single fx.

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4
Q

What is the cause of somnolence syndrome after brain RT?

A

Somnolence syndrome is thought to be caused by demyelination.

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CNS: Low Grade Glioma (3 decks)

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