Women's Hormones Part 1 Flashcards
Estrogen dominance drivers
Obesity, BMI, WHR, Inflammation, Aromatase Activity, Endocrine Disruptors, POPs, Caffeine, Alcohol, Gut Dysbiosis
Luteal phase dysfunction definition
↓Progesterone, shorter luteal
phase <11 days, or <5 ng/mL
maximum serum progesterone
pms drivers
Sx usually from estrogen dominance, progesterone deficiency or stress,
Dysmenorrhea often overlaps w
Overlaps with IBS
PCOS eval and treatment
AMH three times higher in PCOS
PCOS 7 times higher rate of MI
Severe PCOS with higher cortisol and melatonin
high insulin messes up the HPA access which increases LH, leading to androgen secretion, and ovulation, unopposed E, high insulin also leads to lower SHBG and high T
PCOS equals higher zonulin
amenorrhea herbals
Chasteberry, fennel
infertility supp
PCOS give myoinositol 2g b.i.d.
Menorrhagia CAUSES
Hormonal Imbalance common in adolescence & perimenopause DM MET SYN Fibroids, POLYPS • High BMI • Use of anticoagulants • Problems with IUD • Adenomyosis/endometriosis • PID (Pelvic Inflammatory Disease) • Blood clotting disorder such as Von Willebrand’s • Vitamin A Deficiency • Uterine, Ovarian or Cervical Cancer
How does thyroid hormone help with progesterone production?
Thyroid hormones stimulate granulosa cells to produce progesterone (via FSH mediated LH/hCG receptors)
Luteal phase dysfunction treatment
Optimize insulin, can give P cream, lower TSH, weight loss
How to increase SHbG for women
• Vegetarian, low fat diet • Treat hypothyroidism • Treat obesity
How to decrease SHbG for women
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Testosterone therapy
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Exercise GH
Hormones to test on day 3
Estrogens, , fsh, testosterone, dhea shbg*
Hormones to test on day 21 to 24
P, testosterone, dhea shbg*
low Fat vegetarian diet
increase in shbg … less free E
low fat diet dec E
Fiber helps with with E metabolism
Lower the helps with fibroids, PMS, endometriosis