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IFM Hormone > Men's hormones > Flashcards

Men's hormones Flashcards

1
Q

which comorbidities often contribute to decreased T. with aging?

A

Chronic pain with opioid use
dm, met syn
hiv

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2
Q

SHBG changes with age

A

increases

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3
Q

Primary versus secondary low T

A

Primary: failure at testes level, Leydig sensitivity to LH falls. Is related to age.
Secondary: gnRH drops, lh falls. “AOH” - NOT related to age

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4
Q

Diurnal T pattern change with age

A

blunts with age over 45

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5
Q

prev of low T in erectile dysfunction

A

Only 19%

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6
Q

LABS associated with MET SYN

A

low T

low shbg

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7
Q

fsh in men

A

sertoi cells, sperm

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8
Q

lh in men

A

leydig cells, T

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9
Q

17, 20 lyase inhib

A

Inflammation
hyper insulin,
stress
licorice

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10
Q

17, 20 lyase inhib

A

Inflammation
hyper insulin,
stress
licorice

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11
Q

Enzymes affected by insulin

A

17, 20 lyase - makes DHEA and andtostenedione
Five alpha reductase - t to dht
Aromatase

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12
Q

Percentage of AOH with met syn

A

70

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13
Q

Low T & mitochondrial density

A

decrease

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14
Q

imflamm-aging conditions associated with low T

A 
Type 2 DM
CAD and Vascular Diseases
Psoriasis
RA
SLE
Crohn's
COPD/Asthma
Multiple Sclerosis
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15
Q

imflamm-aging conditions with low T

A 
Type 2 DM
CAD and Vascular Diseases
Psoriasis
RA
SLE
Crohn's
COPD/Asthma
Multiple Sclerosis
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16
Q

Low T & atherosclerosis

A

causal!!!

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17
Q

Low T & atherosclerosis

A

YES LINKED

Low tea predicts increased CVD mortality

18
Q

LOW T and mortality

A

88%higher

19
Q

Lifestyle interventions for low T

A

Moderate intensity HV aerobic exercise>200
minutes/week produces greater improvements in sexual function, etc
Strength training increases T levels
hiit increases free total t and shbg

20
Q

Botanicals for Low t

A 
•Long Jack 
•Mucuna 
•Ashwagandha 
•Fenugreek 
black cumin
21
Q

Nutraceuticals/vit for low T

A

vit d (increase in all T), vit A (sperm), zinc, selenium (with cadmium toxicity)

22
Q

lifestyle interventions for prostate health

food

A

Walking decreases prevalence and severity of prostate cancer.
Exercise increases adiponectin which decreases risk of high-grade prostate cancer.

diet avoid AA and Grill’s food. Mediterranean diet, soy, Green tea, lycopene

23
Q

Micronutrient interventions for prostate health

A

vit d, vitamin E, vitamin C, zinc, selenium

24
Q

Botanicals for prostate health

A 
B Sitosterol, 
Pygeum africanum  
Rye GrassPollen extract
stinging nettle root**
Not always saw palmetto**
* together equals awesome
25
Q

Lab eval for Low T

A

total t first, then SHBG and free t, followed by lh/fsh, ferritin estrogen, DHEA, DHT, PSA, cbc

t goal >300
ft goal > 6.6-18.1
shbg 30-80

26
Q

SHBG and age

A

Increases

27
Q

To give for LOW T when you can’t give T

A

DONT give it desiring fertility
Can give hCG instead - like lh
Clomiphene, increases LHFSH

28
Q

H decreased at 30 yo for men

A

T, pregnenolone

proogesterone age 50

29
Q

H decreased at 30 yo for men

A

T, pregnenolone

proogesterone age 50

DHEA decreases

30
Q

E and DHT

A

Decreases metabolism so increased DHT levels and also increases DHT receptors at prostate

31
Q

leptin and IR

A

Insulin resistance leads to TG’s which caused leptin resistance

32
Q

side effects of T replacement

A 
acne
Apnea, 
PSA >4 four
edema,
male pattern baldness
gynecomastia
33
Q

Saw Palmetto

A

dec 5a reductase,
↓ inflammatory PG2/LT4,
(+) apoptosis,
↓E2/DHT receptors.

Studies mixed

34
Q

•

Nettle Root

A

5a reductase inhibition , improves urinary flow;

inflammatory PG/LT & prostatic pain & swelling. Good evidence!

35
Q

Pygeum africanum

A

((–)5 alpha reductase,
↓inflammatory PG/LT,
improves IPSS scores.

36
Q

Rye Grass Pollen

A

–↓prostate cell growth,
inflammation,
↓prostatitis/prostatodynia.

Good evidence

37
Q

Maca Root

A

decreased prostate size in rats

improved sperm counts/quality in humans

38
Q

Beta Sitosterol

A

found in multiple supplements, ( (–) 5a reductase, aromatase

39
Q

zinc

A

–↓ 5 a reductase,
reduces size of prostate,
(–) # of DHT receptors on
prostate by ( (–) prolactin & estrogen affects

40
Q

Chronic prostatitis

A 
Zinc
saw palmetto
 rye grass pollen
 star Grass
agrimony,
 nettle root, 
for certain, 
cranberry, 
Uva Ursi, 
marshmallow root, 
eryngo

IFM Hormone (8 decks)

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