Women's Health Flashcards

1
Q

4 Principles of Practice

A

Safety of our patients
True to our professional pledge (Hippocratic Oath)
Must transform to a value-base system of health care delivery
Must focus on prevention and early mitigation of disease

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2
Q

Barker Hypothesis

A

perturbations / disturbances in the gestational environment may influence the development of adult diseases such as CV disease, obesity, diabetes, and stroke.

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3
Q

Appropriate Age and Interval of health screening for women

A

PAP age 21-29 every 3 years then may do co-testing every five years age 30 to 65.
Annual breast exam at age 40, every 1-3 years before that
Mammogram at age 40 (ACOG) or 50 (USPTF)
Colonoscopy age 50, every 4-5 years
TSH at age 50
Cholesterol/lipids at least every 5 years until 65
BP screening every 2 years at least
Height/Weight BMI every visit
Bone Mineral Density testing age 65+, or younger if risk is present

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4
Q

Preconception screening components and timing

A
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5
Q

Elements of the well woman physical

A

Obstetric History

Menstrual History (age of menarche, intervals, duration, character

Contraceptive History - type and complications

Medical History

Surgical History

Social History

System review and exam (including breast exam)

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6
Q

Differentiate the signs of pregnancy (presumptive, probable, positive)

A

Presumptive - skin and mucous membrane changes. Chadwick sign is the dark discoloration of vulva and vaginal wall. The Chloasma is the pigmentation under the eyes

Probable - Physical changes to uterus. Globular change, softening of uterus

Positive - Fetal heartbeat, fetal movements

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7
Q

Hegar Sign

A

Uterine consitenency is softer and able to palpate the connection between cervix and fundus

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8
Q

Fetal Heartbeat Detection

A

Endovaginal ultrasound - 6-7 weeks (sac identified at 5 weeks)
Doppler - 9-12 weeks
Stethoscope - 16-20 weeks

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9
Q

Fetal movement can be felt

A

7-8 weeks

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10
Q

Benign conditions of the vulva

A

epithelium of the vulva is susceptible to the same skin pathologies seen on other parts of the body. Often the appearance of those processes may be altered by the moisture and warmth of the genital tissue

White lesions , red lesions, or pigmented lesions

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11
Q

Licen sclerosus

A

commonly found in the anogenital area of midlife women. It often presents with intense pruritus, dyspareunia and burning pain, but can also be an asymptomatic finding. Anal involvement can cause constipation. The skin is white, thin, and inelastic, with a crinkled cigarette-paper appearance on gentle stretch. Widespread excoriation is common. It starts with isolated pearly white papules and plaques that coalesce over time and form scars. The result is a “figure of 8” field of scarring from the area encircling the labia, constricting down around the perineal body and ballooning out again around the perineal area into the gluteal cleft. The clitoral hood scars, burying the clitoris. Treat with potent topical steroids.

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12
Q

Hidradenitis suppurativa

A

Painful, recurrent condition of the apocrine glands; results in red papules that have chronic purulent drainage; increased risk with obesity and smoking. Treat with corticosteroid injections in lesions and antibiotics if cellulitis is also present

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13
Q

Seborrheic dermatitis

A

Affects skin folds of genital area; skin has red-glazed shiny appearance; may also find dry, greasy areas of the scalp too. Treat with topical corticosteroids

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14
Q

Vulvovaginal atrophy

A

Occurs in many postmenopausal women; underlying fat of the labia decreased with thinning of the epithelium; appears white and vaginal opening may constrict. Treat with estrogen creams or moisturizers

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15
Q

Aphthous ulcers

A

extremely painful lesions, similar to the “canker sores” found in the mouth. They can be small (<1cm) and eventually heal without scarring, or they can be larger (>2cm diameter and 1cm deep) and cause permanent scarring. Recurrence rates are as high as 35%. Symptomatic care.

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16
Q

Epidermal cysts

A

most common type of genital cyst, peaking in incidence in women in their 40s and 50s and located primarily in the labia majora, labia minora, and inguinal areas. Epidermal cysts develop when the hair follicles become obstructed; the deeper portion of the follicle swells to accommodate the desquamated cells. These cysts are generally dome-shaped, clear white to skin colored lesions rising above the surrounding epithelium. Cosmetic concern.

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17
Q

Urethral caruncle v. overt urethral prolapse

A

caruncle is a solitary red papule at the meatus less than 1cm and dome shaped. A urethral prolapse looks like a swollen red cuff surrounding the meatus and occurs at the extremes of age.

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18
Q

Congenital abnormalities of the vulva

A

The most significant of the vulvar anomalies are those that pose challenges to the assignment of gender at birth. Caution, sensitivity, complete evidence collection, and clear communication with often anxious family members are all required

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19
Q

Female pseudohermaphroditism

A

Female pseudohermaphroditism is caused by in utero masculinization due to androgens from maternal or fetal congenital adrenal hyperplasia, androgen-producing tumors of the mother’s ovary or adrenal glands, or the mother’s use of exogenous androgens. Often the infant will present with ambiguous genitalia.

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20
Q

Androgen insensitivity syndrome

A

Androgen insensitivity syndrome (a form of male pseudohermaphroditism and formerly called testicular feminization) is a genetic deficiency of androgen receptors that results in a 46,XY infant developing female external genitalia and, later in life, secondary sexual characteristics.

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21
Q

Iatrogenic anatomical changes of the vulva

A

may be the result of medical procedures such as episiotomies or cultural dependent such as female genital mutilation.

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22
Q

Benign conditions of the vagina

A

The epithelium of the vagina is also subject to chemical irritants and contact dermatitis and it is also sensitive to estrogen levels.

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23
Q

Vaginal ulceration

A

Most ulceration of the vagina is associated with acute infection due to herpes simplex or cytomegalovirus; vaginal lichen planus may present as ulcers

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24
Q

Bartholin cyst

A

Cystic mass below hymenal ring at 4 or 8 o’clock; must rule out underlying malignancy in older women. Asymptomatic - no treatment, symptomatic - drain with Word catheter

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25
Q

Vaginisumus

A

involuntary contraction of the muscles surrounding the introitus. It may have psychological and/or physical causes, but the contraction makes any vaginal penetration either extremely painful or impossible. Many women with vaginismus report prior sexual abuse, but others may deny any such trauma. It is important that the health care professional understands that vaginismus is an involuntary reaction much like the reflex to shut the eyelid when a foreign object is seen to be approaching. Voluntary control can be learned, but it takes much counseling and patience.

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26
Q

Congenital abnormalities of the vagina

A

Vaginal agenesis represents the most extreme instance of a vaginal anomaly, with total absence of the vagina except for the most distal portion.

The more common structural anomalies of the vagina include canalization defects such as imperforate hymen, transverse and longitudinal vaginal septa, partial vaginal development, and double vagina

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27
Q

Adenosis of the vaginal wall

A

Adenosis of the vaginal wall consists of islands of columnar epithelium in the normal squamous epithelium. It is often located in the upper third of the vagina. The incidence of this finding is much higher in women exposed to diethylstilbestrol in utero.

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28
Q

Differentiate the types of vulvar and vaginal cancer

A

Most tumors are squamous cell carcinomas, and they occur mainly in postmenopausal women. A history of chronic vulvar itching is common and may present with a vulvar lump

Paget disease of the vulva predominantly affects postmenopausal white women, Itching and tenderness are common and may be long-standing. The affected area is usually well demarcated and eczematoid in appearance

Malignant melanoma is a pigmented lesion

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29
Q

Clinical features of vulvar and vaginal cancer

A

Carcinoma in situ of the vagina (vaginal intraepithelial neoplasia [VAIN]) is much less common than its counterparts on the cervix or vulva. Most lesions occur in the upper third of the vagina, and the patients are usually asymptomatic.

30
Q

Management of vulvar and vaginal cancer

A

Interdisciplinary approach, surgical excision with adjuvant radiation and chemo

31
Q

Prognosis of vulvar and vaginal cancer

A

The overall survival rate for vulvar carcinoma is about 70%. The most important prognostic factor is the status of the groin lymph nodes. Patients with positive nodes have a 5-year survival rate of about 50%, whereas those with negative nodes have a 5-year survival rate of about 90%.

32
Q

Bacterial vaginosis

A

Overgrowth of lactobacilli.
Foul or fishy discharge
Thin, gray-white discharge
Itching / burning may indicate co-infection
Positive Whiff test with 10% KOH
Clue cells on wet prep
Treat with metrondiazole for 7 days and a metrondiazole or clindamycin cream

33
Q

Vulvovaginal candidiasis

A

Overgrowth of yeast from hormone imbalance or ABX use
Intense vulvar and vaginal itching, burning, fissuring
Thick / creamy, non-odorous discharge (cottage cheese)
Vulvar erythema causing dysuria
Cutaneous penis legions in partner
Wet prep shows yeast or hyphae
Treat with topical antifungal OTC or if recurring use prescription strength

34
Q

PID

A

Vaginal infection that ascended, usually 15-30 years age
Lower ABD tenderness worse with movement / intercourse
Adnexal tenderness and/or mass
Cervical motion tenderness
Purulent endocervical exudate
Fever, N/V, Discharge, AUB less common
Elevated WBC, STI testing, rule out pregnancy
Treat ceftriaxone IM once with doxycycline / metrondiazole 14 days
Treat partner, refer if severe illness or pregnant

35
Q

Trichomoniasis

A

Protozoan infection
Yellow-green frothy discharge with foul odor
strawberry cervix
Vulvar itching, redness, burning of genitalia
Dysuria
Wet prep shows organism and urine WBC >10
Vaginal pH >4.5
Treat with metrondiazole (7 days women, one time 2g dose men)

36
Q

Gonorrhea

A

STI
May be asymptomatic, dysuria and discharge more common in men
Women may have purulent discharge, lower ABD pain, cervical purulent discharge
Test for pregnancy, vaginal culture, oral culture
Treatment is Ceftriaxone IM and Azithromycin PO once (or doxycycline for 7 days) - co-treating for chlamydia
Avoid sex until 7 days after treatment complete
re-test in 3 months, report to health department

37
Q

Chlamydia

A

May be asymptomatic with dysuria
Muccopurulent cervical discharge
Spotting after intercourse
ABD pain or ‘heaviness’
Friable cervix with errosions / irritations
Urine NAAT and HCG, cervial culture swab
Treat with Azithromycin 1g once (or 7 days doxy), consider also giving ceftriaxone IM to co-treat gonorrhea
Return for re-test in 3 months, report to health department

38
Q

Syphilis Stages

A

Primary - single painless firm ulcer (chancre) that heals in 2-6 weeks

Secondary - nonpruitic rough reddish-brown macular rash on torso, hands, feet and raised white lesions in mouth or perineum. Swollen lymph nodes, anorexia

Latent - Dementia, blindess, deafness, ataxia, numbness, aortic clacification, skin ulcers

39
Q

Syphilis

A

Primary - Penicillin G IM and Probenecid for 14 days
refer to infectious disease and report to health department

40
Q

Herpes

A

Life-long viral infection
Flu-like symptoms with lymphadenopathy, dysuria
Vesicular lesions initially followed by ulcerated area on erythematous base or punched out look, pain at lesion site
HSV PCR test of lesion
Outbreak can be treated within 72 hours with acyclovir
Suppressive therapy if 10+ outbreaks a year

41
Q

Genital Warts

A

Viral lesion caused by HPV
Highly contagious
‘cauliflower’ appearance or flat, domed, or rough papules
Wars can be found on vulva, vaginal opening, anal opening, foreskin, scrotum
May be painful, itchy
Treat with topical ointments, ensure pt is not pregnant
Cryotherapy or acids can be used

42
Q

HPV Vaccine

A

9-14 years old, two doses 6 months apart
15-26 years old, three doses (0, 1-2 months, 6 months)
If doses are less than 5 months between first and final, need a booster

43
Q

Breast Cancer screening recommendations in asymptomatic women

A

ACS - annual at age 40
USPSTF - Every other year at age 50, younger if family history
Annual physician breast exam
Ultrasound / MRI may be useful for dense breast tissue
Definitive diagnosis is made by open biopsy, needle aspiration cytology, or core biopsy. Open biopsy is the gold standard.

44
Q

Common benign breast disorders

A

Hyperplasia, Fibroadenoma, Intraductal Papilioma, Galactocele

45
Q

Breast Hyperplasia

A

Hyperplasia is an overgrowth of the cells that line the lobules (milk-producing glands) or ducts (small tubes) inside the breast. May be seen on mammogram or felt, diagnosed by biopsy. Most common benign breast disorder.

46
Q

Fibroadenoma

A

Most common benign tumor. Sharply circumscribed, freely moveable, more common before age 30. Pregnancy may stimulate their growth

47
Q

Intraductal Papilioma

A

Rarely palpable, often found due to serous, bloody, or turbid nipple discharge. More common just before menopause. Mammographic and cytologic examination of the fluid is helpful in investigating nipple discharge. Excisional biopsy of the lesion and involved duct is the treatment of choice.

48
Q

Galactocele

A

Cystic dilation of a duct filled with thick, inspissated, milky fluid. Presents shortly before or after lactation and implies obstruction. May cause secondary infection and mastitis. Needle aspiration is usually curative.

49
Q

Breast Cancer Etiology

A

Most common malignancy in women, second leading cause of cancer death in women. 1 in 8 chance of developing. 230K cases per year, 40K deaths.

50
Q

Breast Cancer Risk Factors

A

Age 50+
Family history
Early menarche (before 12)
Late menopause
Any breast biopsy
Atypical breast hyperplasia
Hormone replacement therapy

Breast cancer is 5x higher than in Asia
5-10% result from BRCA1/2 gene

51
Q

Types of Tumors in Breast Cancer

A

80% are nonspecific infiltrating ductal carcinomas
Less common types include infiltrating lobular, medullary, mucinous, tubular, and papillary tumors

Inflammatory breast cancer is very rare, usually only in younger women and has warmth, redness, induration of breast tissue

52
Q

Paget Disease of the Breast

A

Paget disease of the breast occurs in about 3% of patients with breast cancer. It represents a specific subtype of intraductal carcinoma that arises in the main excretory ducts of the breasts and extends to involve the skin of the nipple and areola, producing an eczematoid appearance. The underlying carcinoma, although invariably present, can be palpated clinically in only about two-thirds of patients.

53
Q

Breast Cancer Spread

A

Local infiltration
Lymph spread to axillary nodes then internal mammary nodes, then supraclavicular nodes after axillary
Spread into secondary areas such as lungs, liver, bone, ovaries later

54
Q

Staging in Breast Cancer

A

Staging of Primary Tumor (T) and Regional Lymph Nodes (N)
0 - no sign
T1 - Tumor 2 cm or less
T2 - Tumor 5 cm or less
T3 - Tumor greater than 5 cm
T4 - Any size tumor that extends to chest wall or skin

N1 - Ipsilateral node axillary moveable
N2 - Axillary non-moveable or mammary nodes spread
N3 - Supraclavicular/Infraclavicular

55
Q

Clinical features of breast cancer

A

Carcinoma of the breast is usually painless and may be freely mobile. A serous or bloody nipple discharge may be present. With progressive growth, the tumor may become fixed to the deep fascia. Extension to the skin may cause retraction and dimpling, whereas ductal involvement may cause nipple retraction. Blockage of skin lymphatics may cause lymphedema and thickening of the skin, a change referred to as peau d’orange

56
Q

Treatment / prognosis of breast cancer

A

Multidisciplinary approach
Local excision / breast sparing is more common with adjuvant radiation therapy / chemotherapy as adjuvant reduces relapse risk by 1/3 and death by 30%
Routine axillary lymph node dissection has progressively been replaced by lymphatic mapping and sentinel lymph node biopsy

Status of lymph nodes is the most important prognosis factor.

57
Q

Etiology and epidemiology of cervical cancer

A

studies have identified persistent infection with a high-risk human papillomavirus (HPV) as the cause of virtually all cervical cancers.

58
Q

Risk factors for cervical cancer

A

Young at first coitus (<17)
Multiple partners
Young age at first pregnancy
High parity
Low socioeconomic
Smoking

59
Q

Atrophic vaginitis

A

Atrophic vaginitis is inflammation of the vagina as a result of tissue thinning due to not enough estrogen. Symptoms may include pain with sex, vaginal itchiness or dryness, and an urge to urinate or burning with urination. It generally does not resolve without ongoing treatment. Complications may include urinary tract infections.

The lack of estrogen typically occurs following menopause.

60
Q

Inflammatory vaginitis

A

vaginitis is an inflammation of the vagina that can result in discharge, itching and pain. The cause is usually a change in the balance of vaginal bacteria or an infection. Reduced estrogen levels after menopause and some skin disorders also can cause vaginitis. Bacterial, yeast, Trich are most common causes.

61
Q

Endocervicitis

A

Cervicitis is an inflammation of the cervix, the lower, narrow end of the uterus that opens into the vagina.

Possible symptoms of cervicitis include bleeding between menstrual periods, pain with intercourse or during a pelvic exam, and abnormal vaginal discharge. However, it’s also possible to have cervicitis and not experience any signs or symptoms.

Often, cervicitis results from a sexually transmitted infection

62
Q

Tubo-ovarian Cyst

A

A tubo-ovarian abscess is a pocket of pus that forms because of an infection in a fallopian tube and ovary. A tubo-ovarian abscess is most often caused by pelvic inflammatory disease (PID)

63
Q

Acute and recurrent cystitis

A

Recurrent = more than 2 in six months or more than 3 in one year. Requires prophylaxis treatment.

64
Q

Urethritis

A

Both bacteria and viruses may cause urethritis. Some of the bacteria that cause this condition include E coli, chlamydia, and gonorrhea. These bacteria also cause urinary tract infections and some sexually transmitted diseases. Viral causes are herpes simplex virus and cytomegalovirus.

65
Q

Acute Pyelonephritis

A

Inflammation of the kidney. Usually organism ascends from urethra to cause the infection. Chills, fever, N/V, CVA tenderness, foul urine, dysuria.

66
Q

Chorioamnionitis

A

Chorioamnionitis is an infection of the placenta and the amniotic fluid. It happens more often when the amniotic sac is broken for a long time before birth. The major symptom is fever. Other symptoms include a fast heart rate, sore or painful uterus, and amniotic fluid that smells bad.

67
Q

Postpartum endometritis

A

Postpartum endometritis refers to infection of the decidua (ie, pregnancy endometrium). It is a common cause of postpartum fever and uterine tenderness. Fever, chills, malaise are common.

68
Q

Postabortal infection

A

postabortal infection as a pelvic infection that occurs within 4 to 6 weeks following an abortion procedure

69
Q

HIV

A
70
Q

HEP B and C

A
71
Q

Perinatal infections

A