Wolters Summary - Antidepressants Flashcards
other factors causing depression
beta blockers can cause depression
SSRI MOA
inhibit reuptake of serotonin
SERT rec.
list SSRI
fluoxetine/prozac sertraline/zoloft paroxetine/paxil escitalopram/lexapro citalopram/celexa fluvoxamine
fluoxetine
prozac
sertraline
zoloft
paroxetine
paxil
x
escitalopram
lexapro
citalopram
celexa
SSRI side effects
- GI
- CNS
- erectile dysfunciton
- Anticholinergic
- Hyponatremia
- QTc prolongation
* * can help hot flashes
GI s.e. of SSRI
n/v
dry mouth
CNS s.e. of SSRI
sedation
insomnia
decreased libido
suicidal ideation
drug causing most s.e. of SSRI
paxil/paroxetine
SSRI with longest half life
Prozac
shortest- paxil so have more s.e.
SSRi causing QTc prolongation
escitalopram
citalopram
esp. citalopram
SSRi drug interactions
other serotonergic meds (esp. MAOis and linezolid)
fluoxetine
Fluoxetine and clopidogrel
Prozac is a CYP219 INHIBITOR and Clopidogrel is PRODRUG
so if taking prozac, clopidogrel will not work
same for tamoxifen
SNRI
list
Venlafaxine (Effexor)
Desvenlafaxine
Duloxetine (Cymbalta)
Levomilnacipran