Bipolar Disorders Flashcards

1
Q

Most poorly understood neuropsychiatric disorders and most disabling

A

Bipolar disorder

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2
Q

Subthreshold bipolar

A

Having 2 or more core features of hypomania but not meeting proper criteria

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3
Q

Risk factors if bipolar

A

1st degree relative with BPD (7-10x)

Season of birth

Stressful life event

Traumatic brain injury

MS

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4
Q

BPD characterized by

A

Mood episodes (changes in mood with associated symptoms)

Building block of disease

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5
Q

Key feature for a diagnosis of BPD

A

At least one episode meeting criteria for manic, hypomanic, or mixed

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6
Q

Types of mood episodes (4)

A

Manic
Hypomanic
Mixed
Depressed

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7
Q

DSM-5 criteria A

MANIC EPISODE

A

Distinct period of abnormally/persistently elevated, expansive or irritable mood AND abnormally persistently increased goal directed active OR energy for 1 week (have so much energy)

Abnormally happy

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8
Q

Criteria B

Manic episode

A

If they have criteria A

If euphoric/expansive = 3
Irritable = 4

Grandiosity/inflated self esteem 
Diminished need for sleep 
More talkative 
Flight of ideas 
Distracting little 
Increased goal directed activity 
Excessive pleasurable activity
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9
Q

Diagnostic criteria

Hypomanic Criteria A

A

Distinct period of abnormally and persistently elevated, expansive, irritable mood AND abnormally and persistently increased energy or activity for 4+ days

SAME as manic but not as severe (criteria B is also same)

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10
Q

Criteria E

Hypomanic

A

Not severe enough to cause marked impairment or necessitate hospitalization (psychosis episode is by definition manic)

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11
Q

Notable difference with hypomania

A

Changes must be observable by others

Symptoms represent change from baseline

Symptoms do not cause impairment (labeled manic)

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12
Q

At least one prior episode of mania

A

BPD I

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13
Q

No manic, has hypomania. More than one episode of MDD

A

BPD II

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14
Q

No mania, mixed, no hypomania

A

MDD

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15
Q

No mania, mixed, can have elevation, can have depression symptoms

A

Cyclothymic

Some symptoms of everything but don’t meet criteria for any one disease

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16
Q

Specifies of bipolar

A
Anxious distress
Mixed features 
Mood congruent 
Catatonic 
Peri partum  
Seasonal pattern 
Severity
17
Q

Mixed features

A

Can be applied to episodes of mania, hypomania, depression

Mania or hypomania with symptoms of depression

Depressive episode with mixed features

Mixed features correlates with suicidality, anxiety, and early onset

18
Q

BPD I and BPD II are at very ___ rates of suicide

A

High

50% have suicidal ideation and 20% attempt suicide

19
Q

Cognitive deficits

A

Can be present during episodes and outside of episodes

Include impaired attention and executive functioning

20
Q

Features of longitudinal course

A

Age of onset: teens to 20s

Most of time in depressive episode

BPD I patients experience mixed episode in illness

Rapid cycling = worse prognosis

SSRI switching is not actually common

21
Q

Rapid cycling

A

> 4 episodes/year

22
Q

Neurobiology of BPD

A

White matter connectivity abnormalities

Increased volume in striatum and amygdala

Decrease PFC activation (ventral and medial lateral)

Increased amygdala activation

23
Q

Genetics of BPD

A

Highly heritable

L-type VG-Va channel (lithium)

80% of risk = inherited

24
Q

Presence of psychosis without mood symptoms is differentiating factor

A

Schizophrenia/schizoaffective

25
Q

Treatment

A

Education

Medication

Therapy

Other

Must determine mood state

Acute and maintainence treating

Regular sleep schedule

26
Q

SSRIs

A

Can be good for use with an initial episode if used in combination with lithium

27
Q

Avoid __ drugs

A

Tricyclics antidepressants and venlafexine