WK7: Coagulation Cascade & Fibrinolysis

Question 1

series of enzymatic conversions of proenzymes to activated enzymes

Answer 1

coagulation cascade

Question 2

The coagulation cascade ends with ______ & ______

Answer 2

formation of fibrin strands

Termination of cascade (anti-thrombotic mechanisms)

Question 3

Most activated factors are enzymes except: ___, ___ & ___

Answer 3

Ia (fibrin)
Va
VIIIa

Question 4

Proaccelerin, labile factor

Answer 4

factor V

Question 5

Antihemophilic factor

Answer 5

factor VIII

Question 6

True or False:

The traditional model explains lab findings in vivo

Answer 6

false (in vitro)

Question 7

Extrinsic Pathway includes _______

Answer 7

Tissue factor
VII
X

Question 8

Intrinsic Pathway includes _______

Answer 8

VIII
IX
X
XI
XII

Question 9

Common pathway includes

Answer 9

X
Thrombin
Fibrin

Question 10

In the contemporary model, there are 4 key multicomponent complexes, each of which consists of an _____, _____, & _____

Answer 10

activated CF enzyme
cofactor
Enzyme subratre

Question 11

Cofactor of Extrinsic X-ase

Answer 11

Tissue factor

Question 12

Enzyme of Extrinsic X-ase

Answer 12

VIIa

Question 13

Substrate of Extrinsic X-ase

Answer 13

X

Question 14

Enzyme of Intrinsic X-ase

Answer 14

IXa

Question 15

Cofactor of Intrinsic X-ase

Answer 15

VIIIa

Question 16

Substrate of Intrinsic X-ase

Answer 16

X

Question 17

Enzyme of prothrombinase

Answer 17

Xa

Question 18

Cofactor of prothrombinase

Answer 18

Va

Question 19

Substrate of prothrombinase

Answer 19

Prothrombin

Question 20

Enzyme of Protein C Complex

Answer 20

Thrombin

Question 21

Cofactor of Protein C Complex

Answer 21

Thrombomodulin

Question 22

Substrate of Protein C Complex

Answer 22

Protein C

Question 23

Relies on tissue factor to activate the whole cascade

Answer 23

Contemporary Model

Question 24

Has a key role in amplification phase

Answer 24

vWF

Question 25

3 main antithrombotic control mechanisms

Answer 25

Antithrombin Protein C Pathway Tissue factor pathway inhibitor

Question 26

A serpin that inactivates thrombin, VIIa, IXa, Xa and XIa

Answer 26

Antithrombin

Question 27

True or False: | Altered thrombin is capable of activating PLTs or converting fibrinogen to fibrin but cannot activate protein C

Answer 27

False (Incapable of activating PLTS/Converting fibrinogen) (can activate protein C)

Question 28

A single chain polypeptide which can reversibly inhibit Xa and VIIa-TF complex

Answer 28

Tissue Factor Inhibitor

Question 29

Process which removes clots from the body

Answer 29

Fibrinolysis

Question 30

Two major steps in fibrinolysis

Answer 30

Plasminogen is converted into plasmin Plasmin cleaves fibrin

Question 31

Secreted from vascular endothelial cells

Answer 31

t-Pa (Tissue type plasminogen activator)

Question 32

Secreted from a variety of cell types

Answer 32

u-Pa (urinary type plasminogen activator)

Question 33

True or False: | the presence of D-dimer indicates intravascular clotting

Answer 33

True

Question 34

Inactivates t-PA and u-PA

Answer 34

Plasminogen Activator Inhibitor 1 (PAI-1)

Question 35

Inactivates plasmin

Answer 35

Alpha 2 Antiplasmin (a2AP)

Question 36

Acts on fibrin by cleaving the end c-terminal

Answer 36

Thrombin Activatable Fibrinolysis Inhibitor (TAFI)