WK11: Disorders of Thrombosis

Question 1

nappropriate formation of platelet or fibrin clots or excessive clot that obstruct blood vessels inhibiting blood flow

Answer 1

Thrombosis

Question 2

The PREDISPOSITION for thrombosis

Answer 2

Thrombophilia or

HYPERCOAGULABILITY

Question 3

Clot that travels away from the its source

Answer 3

Embolus

Question 4

Major factors in the formation of thrombosis

Answer 4

Endothelial Injury
Hypercoagulability
Abnormal Blood Flow

Question 5

Ongoing coagulation process and sometimes there is an overreaction forming tremendous amount of blood clots

Answer 5

Hypercoagulability

Question 6

Kunitz-1: inhibits VIIa:TF complex Kunitz-2: inhibits Xa

Answer 6

TFPI (Kunitz)

Question 7

Inhibits Va and VIIIa

Answer 7

APC

Question 8

Inhibits thrombin, IXa, Xa, Contact grp (XI, XII, Prekalikrein, HMWK)

Answer 8

AT

Antithrombin III

Question 9

Inhibits Xa and XIa

Answer 9

ZPI

Question 10

Cofactor of APC and TFPI

Answer 10

Protein S

Question 11

Solely Inhibits thrombin

Answer 11

Heparin cofactor II

Question 12

Binds to thrombin to activate Protein C

Answer 12

Thrombomodulin

Question 13

most common form of venous thrombosis

Answer 13

DVT (deep vein thrombosis)

Question 14

Most common cause of myocardial infarction and strokes

Answer 14

Arterial Thrombosis

Question 15

occurs in atherosclerosis composed of fats, platelets, calcium deposits

Answer 15

White thrombi

Question 16

deficiency involved in liver disease, proteinuria, prolonged heparin therapy and DIC

Answer 16

AT deficiency

Question 17

AT s decreased/ absent (type I or II)

Answer 17

Type I

Question 18

Nonfunctional AT (type I or II)

Answer 18

Type II

Question 19

Non-specific; diagnose type I and II AT deficiency

Answer 19

AT activity Assay

Question 20

In AT activity assay the substrate end color is _____

Answer 20

yellow

Question 21

True or False:

When the substate is less yellow there is less AT

Answer 21

False (indirectly proportional - less yellow, more AT)

Question 22

Diminished light (Decreased AT)

Answer 22

Type 1

Question 23

Normal (non-functional AT)

Answer 23

Type 2

Question 24

Activator of APC

Answer 24

Thrombin-thrombomodulin complex

Question 25

Cofactor of APC

Answer 25

Protein S

Question 26

problem in factor V Leiden mutation

Answer 26

APC Resistance

Question 27

True or False | In APC resistance glutamine substitues arginine

Answer 27

False (Arginine substitutes Glutamine)

Question 28

Protein C & S Deficiency

Answer 28

prolonged Warfarin

Question 29

Antithrombin deficiency

Answer 29

prolonged Heparin

Question 30

Reagent of Protein C

Answer 30

Protac

Question 31

True or False: | In protein S deficiency there is prolonged clotting time

Answer 31

False (shortened)

Question 32

Implicated in stroke in young adults

Answer 32

Homocytinemia

Question 33

These are acquired autoantibodies against certain clotting factors that are associated with systemic immune diseases

Answer 33

Acquired coagulation inhibitors

Question 34

confirmatory test QUANTItative assay for autoanti-VIII titer

Answer 34

Bethesda Assay

Question 35

Caused by heparin targeting platelet factor 4 stabilizes platelets

Answer 35

Thrombocytopenia

Question 36

can casue HIT | aPTT monitored

Answer 36

Unfractionated Heparin (UFH)

Question 37

Can cause HIT | aPTT is not monitored

Answer 37

``` Low-Molecular Weight Heparin (LMWH) ```

Question 38

Manmade heparin - Overdose has no antidote

Answer 38

Fondaparinux

Question 39

It is not a primary disease, but a SECONDARY to another autoimmune disease

Answer 39

APAS

Question 40

APAS is suspected if there is _____, _____ and ______

Answer 40

Unexplained thrombosis Thrombocytopenia Recurrent fetal loss

Question 41

If TT is prolonged add _____

Answer 41

hepzyme

Question 42

Prolonged TT | PTT CORRECTED after Hepzyme

Answer 42

Heparin Overdose

Question 43

PTT prolonged | PTT NOT CORRECTED after Normal Plasma (no incubation)

Answer 43

Lupus Anticoagulant

Question 44

PTT prolonged | PTT CORRECTED after INCUBATION with Normal Plasma

Answer 44

CF deficiency

Question 45

PTT prolonged | PTT NOT CORRECTED after INCUBATION with Normal Plasma

Answer 45

Anticoagulant Excess

Question 46

Activates VII (Extrinsic Pathway)

Answer 46

DTT (Diluted Thromboplastin time)

Question 47

Activates X (common pathway)

Answer 47

DRVVT (Diluted Russell Viper Venom Time)

Question 48

Activates XII (intrinsic pathway)

Answer 48

KCT (Kaolin CT) and PTT

Question 49

Thrombosis found in pancreatic cancer and colon cancer

Answer 49

Trousseau Syndrome

Question 50

Faggot cells seen under microscope w/ Auer rods

Answer 50

M3 or APML

Question 51

PIGA mutation causing deficiencies of DAF (CD55) and MIRL (CD59)

Answer 51

PNH (Paroxysmal Nocturnal Hemoglobinuria)

Question 52

True or False: | In DIC, CT, PT and PTT are prolonged

Answer 52

True

Question 53

Confirmatory test for DIC

Answer 53

D-Dimer

Question 54

True or False: | In DIC spherocytes are seen in PBS

Answer 54

False (schistocytes)

Question 55

Used as a marker for thrombosis

Answer 55

D-Dimer

Question 56

Actions of fragments (FDP)

Answer 56

Inhibit hemostasis Prevents PLT activation Hinders fibrin polymerization

Question 57

Plasmin degrades to form __ and ___ | complex

Answer 57

YY | DXD

Question 58

Fragment Y

Answer 58

D-E

Question 59

Final product of fragment D and E

Answer 59

E/D/D

Question 60

Fragment YY

Answer 60

D-E/D-E