WK2_19 Metabolic Diseases & Genetic Testing

Question 1

most inherited disorders of metabolism are caused by mutations in which of the following?

Answer 1

genes that code for metabolic enzymes

Question 2

prenatal screenign for metabolic disorders is indicated when:

Answer 2

• the parents have an affected child
• the marriage is consanguineous
• there is a family history of the disorder

Question 3

T/F Codeine is a pro-drug that is metabolized into morphine

Answer 3

TRUE

Question 4

T/F Codeine is metabolized by the product of the CYP2D6 gene

Answer 4

TRUE

Question 5

T/F Codeineis metabolized by the product of the CYP2C19 gene

Answer 5

FALSE

Question 6

T/F ultrarapid metabolizers of codeine have excess of the gene encoding the enzyme

Answer 6

TRUE

Question 7

T/F ultrarapid metabolizers of codeine are likely to have higher plasma levels of morphine after taking the same dose of codeine as poor metabolizers

Answer 7

TRUE