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MV > WK14: DNA Viruses > Flashcards

WK14: DNA Viruses Flashcards

1
Q

Naked, Icosahedral, dsDNA

A

ADENOVIRIDAE

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2
Q

Most common serotypes of adenoviridae

A

1, 8, 11, 21, 35, 37, 40

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3
Q

Adenovirus can cause: (3)

A

Epidemic keratoconjunctivitis
Acute hemorrhagic cystitis
Pharyngoconjunctival fever

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4
Q

Causes severe, fatal ACUTE RESPIRATORY DISEASE (ARD)

A

Serotype 14

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5
Q

enteric adenoviruses

A

serotype 40 and 41

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6
Q

Adenoviridae is isolated in _______ and _______

A

Human embryonic kidney

continuous Epithelial cell lines

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7
Q

Enveloped, Icosahedral, Linear dsDNA

A

Herpesviridae

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8
Q

Amorphous integument surrounding the capsule

A

Herpesviridae

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9
Q

True or False

Not all herpesviruses produce latency and lifelong persistence in their hosts

A

False (ALL)

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10
Q

HSV-1 & HSV-2 belong to Genus: _____

A

Simplexvirus

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11
Q

Transmission of HSV

A

Contact with contaminated secretions

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12
Q

Oral herpes is caused by ____

A

HSV-2

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13
Q

Transmission of HSV from infected mother

A

Neonatal herpes

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14
Q

reduces the risk of neonatal herpes

A

CESAREAN OR SUPPRESSIVE ANTIVIRAL THERAPY

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15
Q

leading cause of fatal sporadic encephalitis

A

HSV

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16
Q

Caused by HSV-2 (neonates) & HSV-1 (older children,

adults)

A

Encephalitis

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17
Q

HSV of the conjunctiva

A

Ocular Herpes

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18
Q

best for detection of HSV

A

Antigen detection or Viral isolation

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19
Q

gene for the enzyme B-galactosidase linked to a virus- induced promoter is inserted into baby hamster kidney cells

A

ELVIS test

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20
Q

If HSV-1 is present in the cell lineA viral protein will activate the promoter resulting in __________

A

B-galactosidase expression

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21
Q

Detection of HSV-1 in elvis test forms ____ color

A

blue

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22
Q

Leading cause of mental retardation, deafness, intellectual impairment

A

CMV

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23
Q

CMV is shed in

A 
Saliva
Tears
Urine
Stool
Breast milk
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24
Q

CMV is Best confirmed by Isolation of virus from: ________

A

Normally sterile body fluids

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25
Q

Used for blood donor screening and diagnostic applications of CMV

A

PCR, branched DNA, Hybridization assays

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26
Q

True or False:
Congenital infection is best confirmed by isolation of CMV from the infant with
first 3 weeks of life

A

False (2 weeks)

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27
Q

Viral antigenemia test is based on immunocytochemical detection of

A

65-kilodalton (kDa)

Lower-matrix phosphoprotein (pp65)

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28
Q

Infectious mononucleosis

A

EBV

29
Q

Reye Syndrome is a complication in a patient with _____

A

EBV

30
Q

Malignant disease of lymphoid tissue

A

Burkitt lymphoma (EBV)

31
Q

Incubation period of EBV

A

2 weeks - 2 months

32
Q

EBV infects circulating B lymphocytes and stimulates them to produce multiple ________

A

heterophile antibodies

33
Q

Excellent rapid screening test for heterophile antibodies

A

Paul-Bunnel Heterophile Antibody Test

34
Q

antibodies against the viral capsid antigen

A

ANTI-VCA

35
Q

IgG antibody to early antigen

A

ANTI-EA IgG

36
Q

antibody to early antigen, diffuse

A

ANTI-EA/D

37
Q

elevated in patients with

Burkitt lymphoma

A

Anti-EA/R IgG antibody level

38
Q

Transmission of VZV

A

Droplet inhalation

Direct contact with infectious lesions

39
Q

Produced at very high levels in the skin vesicles

A

Cell free virus

40
Q

Reactivation of VZV

A

Zoster = Shingles

41
Q

Vesicular lesions In unilateral dermatome pattern

A

VZV

42
Q

Confirms the diagnosis of VZV

A

Culture of fresh lesions (vesicles)

Fluorescent-labeled monoclonal antibodies

43
Q

True or False:

cytopathic changes of VZV is evident in 3-7 days

A

False (may not be evident)

44
Q

standard for diagnosis of VZV

A

PCR

45
Q

transmission of HHSV-6

A

saliva

46
Q

HHSV-6 is associated with childhood disease _____

A

Roseola

47
Q

Most sensitive and specific means of diagnosing primary HHV-6

A

PCR and Viral load testing

48
Q

receptor for HHV-7 to infect T lymphocytes

A

CD4

49
Q

Causes roseola

A

HHV 7

50
Q

Kaposi sarcoma-associated herpesvirus

A

HHV8

51
Q

HHV8 Plays a role in development of:

________ & ________

A

Primary effusion lymphomas

Multicentric Castleman disease

52
Q

Includes types infecting the genital/nongenital mucosa, genital cutaneous surfaces, types seen in human cancers

A

Alphapapillomavirus

53
Q

Papillomas or warts caused by HPVs

A

papillomaviridae

54
Q

infect all children and young adults universally, with no

significant consequences

A

HPV 1, 2, 3, 4

55
Q

in the detection of papillomavirus Cytotechnologists & cytopathologists read Pap smears and look for ________

A

koilocytes

56
Q

Cells with perinuclear clearing accompanied by an increased density of the surrounding rim of cytoplasm

A

koilocytes

57
Q

Help detect HPV DNA in endocervical cells

A

Nucleic Acid Probes

58
Q

causes small pox

A

Variola virus

59
Q

variola virus is characterized as ________ accompanied by fever

A

Synchronous progressive rash

60
Q

Virus was introduced into the country by rodents imported from Africa

A

Monkeypox virus

61
Q

Vesicular, pustular febrile illness

A

nonkeypox virus

62
Q

Smallest DNA virus

A

Parvoviridae

63
Q

Principal pathogen of parvoviridae

A

parvovirus B19

64
Q

Fifth disease

A

Erthema Infectiosum

65
Q

rashes give a slapped cheek appearance

A

prodromal phase

66
Q

Cause transient aplastic crisis, a self-limiting erythropoietic arrest

A

Parvovirus B19 Virema

67
Q

Parvovirus B19 Virema is characterized by decrease in ______

A

RBC production (bone marrow)

68
Q

Closely related to: Bovine parvovirus and Canine minute virus

A

P Human Bocavirus (HBoV)

69
Q

HBoV is a coinfection with _____ and ______

A

RSV & Human metapneumovirus (hMPV)

MV (4 decks)

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