Wk 9: Causes of cancer Flashcards
Give examples of things that may cause cancer
- Ionising radiation
- Genetics
- Asbestos
- Viruses
- Diet
- Hormones
- Parasites
- Cigs
- Sun
What is smoking associated w/ in terms of cancer?
- 15% of cancer
- 7 types
Give examples of 3 main ways alcohol causes damage?
- Acetaldehyde: damage cells
- Hormone changes: oestrogen, insulin
- Inc abs
Outline the effects of UV light
- UV-B: sunburn + direct damage to DNA
- UV-A: free radical formation
- UV-C: blocked by ozone
What are the 2 types of non-melanoma skin cancers?
- Basal cell carcinoma: cells lining bottom of epidermis (75%)
- Squamous cell carcinoma: cells lining top of epidermis (20%)
What is malignant melanoma?
- Majority of skin cancer related deaths
- Treatment: surgery
Outline dietary factors that may affects chances of cancer
- Fruit, veg, whole grains + healthy fat = dec cancer
- Red meat: inc colon + breast cancer
- Vit D: high intake + plasma level dec cancer
What is the benefits of physical activity in regards to cancer?
- For primary prevention of cancer
- Lower hormone levels (insulin)
- Red: colon, breast + endometrial
- Beneficial during treatment + survivors
Give examples of hormone driven cancers
- Breast
- Gynaecological cancers
- Prostate
Outline the risk of hormones when causing cancer
- Enter cell + cause cell to make protein, changing cell behaviour
- Overstim of hormone receptor = excessive cell multiplication
What is the percentage of cancers diagnosed is linked to inherited gene?
3 -10%
What have studies found regarding the correlation btw geography and cancers?
Migrating population = changes of cancer tending towards indigenous population - chinese moving to US less likely to develop stomach cancer if western diet adopted
Give examples of viruses that can cause cancer
- HPV - cervical
- HBV/HCV - liver
- EBV - Lymphoma
Give examples of how immunosuppression inc incidences of cancer
- AIDS syndrome develop malignancy
- Transplant recipients: Inc kaposi sarcoma, non-hodgkin lymphoma + skin cancer
Give examples of chemical factors that may cause cancer
- Smoking
- Asbestos
- Alcohol