WK 4- MHC COMPLEX, ANTIGEN PROCESSING AND PRESENTATION Flashcards
What is MHC also called
HLA
What is the MHC
MHC is a cluster of genes which form a molecule on the surface of cells- aids in presenting peptides from pathogens. MHC determines if transplanted tissue is compatible between donor and host.
Where is MHC1 found
MHC1 is found on all nucleated cells, including plasma cells
Where is MHC2 found
Found on subsets of haematopoietic cells- APC (dendritic, macrophage and NK cells)
What genes encode for MHC1
Alpha chain is encoded by HLA-A, HLA-B, HLA-C
What genes encode for MHC2
Alpha and beta chains are encoded by HLA-DR, HLA-DP, HLA-DQ
What MHC complex presents peptides from intracellular pathogens
MHC1 expresses peptides from pathogens that reside within the cell-> MHC1 presents the peptides to CD8 cytotoxic cells
What MHC complex presents peptides from exogenous peptides
MHC2 expresses peptides from pathogens that were exogenous and then engulfed and broken down-> presents them to CD4T cells
What is MHC restriction
MHC restriction is the requirement that APC cells express MHC molecules that the T cell recognizes and matches, in order for T cell to respond to the antigen presented by that APC. (T cells will only recognize antigens presented by their own specific MHC molecules- allows for T cell specificity)
What does polygeny mean
MHC molecules display polygeny as they have multiple genes encoding for the same structure/function
What does polymorphic mean
Refers to a minor difference between genes-> caused by inheriting multiple alleles for each gene because you inherit combinations from each parent, and both are expressed
What is a haplotype
A set of genetic determinants located on a single chromosome and inherited as a block- the HLA genes from each parent are inherited as a haplotype
True or false, HLA genes are expressed co-dominantly
True- each inherited gene is expressed-> polygeny and polymorphism contribute to diversity
What is an altered cell
Altered cells are those which are infected with a virus or cancer-> MHC1 allows for these cells to be identified and killed by cytotoxic CD8T cells
What is antigen processing
Generation of peptides from intact antigens-> must occur in order for MHC to present signals to T cells (T cells only recognise peptides)