Wk 3 - Methodology Flashcards
Eight methods for visualising/stimulating the brain
Contrast x-rays X-ray computed tomography (CaT) Positron Emission Tomography (PET) Magnetic Resonance Imaging fMRI Paired image subtraction method Transcranial magnetic stimulation Magnetoencephalography (MEG)
Five methods for recording psychophysiological activity
Electroencephalography (EEG) Electromyography (EMG) Electroculography (EOG) Skin conductance Cardiovascular activity (through electrocardiogram, blood pressure etc)
Seven invasive methods for studying brain activity
Stereotaxic surgery Lesioning Invasive electrophysiological methods Pharmacological methods Chemical lesions Measuring chemical activity Genetic studies/engineering
Three behavioural methods of biopsychology
Neuropsychological testing
Language lateralisation
Secondary tests of frontal lobe function
Contrast x-rays - function (x1) plus dis/advantages (x1)
Shows abnormalities of blood vessels, eg tumors, blockages
Good for medical diagnosis, but not brain function
X-ray computed tomography (CaT scan) - function (x1) plus dis/advantages (x2)
Computer creates 3D image from many slices
Higher spatial res than x-ray,
Doesn’t tell which regions are active
Positron Emission Tomography (PET) - involves (x1), which gives (x1) plus dis/advantages (x4)
Inject or inhale a radioactive isotope
Gives correlational evidence - brain activity associated with particular input
Very expensive = uncommon, creation of own isotopes, invasive, side-effects
Magnetic resonance imaging… (x1) - plus method (x2), plus dis/advantages (x1)
Detects waves emitted from hydrogen atoms in magnetic field, which lines up atoms in row
Magnet pulses on and off, atoms snap in and out of alignment
Imaging detects waves produced as they fall out of alignment
Can see brain during processes
fMRI relies on the fact that... (x1) - the ??? signal (x1) Plus advantages (x4) and disadvantages (x1)
Oxygenated blood has magnetic properties
BOLD signal: Blood Oxygen Level Dependent signal.
Advantages:
Gives anatomical info, which PET doesn’t
Very high spatial res – about 1mm cubes
Non-invasive
Structural/functional info in same image.
Disadvantages:
Temporal res – due to blood taking time to move around, even though brain activates more quickly. Maybe 1-1.5 second lag/uncertainty
Paired image subtraction method (x1), plus dis/advantages (x2)
Taking aggregate of bunch of people
Increase confidence in results
Still correlational, not causal…
Transcranial magnetic stimulation entails… (x2)
Plus dis/advantages (x1)
Single magnetic pulses applied locations on scalp at specific times during task; or repetitively prior to task (rTMS/“virtual lesioning”) disrupts activity
Cognitive/behavioural consequences then observed.
Permits causal inference about specific brain region for given task - adjunct to PET/fMRI.
Magnetoencephalography (MEG) (x1)
Plus dis/advantages (x2)
Detects tiny magnetic fields on surface of scalp, generated perpendicular to electrical current going down a wire
Recording through tissue trashes spatial res – very good temporal
But, combine fMRI scan while doing task to get location
Electroencephalography (EEG) functions to… (x1)
By… (x1)
Plus dis/advantages (x2)
Records all brain activity at particular time –
Taking aggregate info, average over many trials, identify wave patterns that emerge
Not very accurate - maybe used within fMRI scanner = structural data too
Electromyography (EMG) (x2)
Recording signal from specific muscles - the action potential spikes associated with muscle activity
Integrated EMG signal smoothes data, gives clearer view of timing of events
Electrooculography (EOG) (x2)
Monitors specific contractions of six eye muscles
Can tell where eye is moving, eg left and right by recording lateral and medial rectus muscle
Skin conductance is… (x2)
Plus 2 measurements
Primary method in fear conditioning, phobias etc
As often changes in response to emotional stimuli.
SCL: the skin conductance level (baseline)
SCR: the skin conductance response, the change in skin conductance in response to a stimulus.