Wilm's Tumour

Question 1

What is the system of origin in Wilm’s tumour?

Answer 1

Also known as a nephroblastoma.

Wilms’ tumour is a undifferentiated mesodermal malignancy affecting the kidney in children and rarely in adulthood.

Question 2

What are the typical signs and symptoms?

Answer 2

Usually presents as an assymptomatic abdominal mass.

May present with:

• abdominal pain
• haematuria
• UTI’s

Question 3

What are the common associations?

Answer 3

Overgrowth syndromes (Beckwith-Wiedemann syndrome + others)

Trisomy 18 (Edwards)

Wilms’ with Aniridia, Gonadoblastoma (GU malformations), and Retardation (WAGR).

Can have Familial Wilms Tumour, autosomal dominant transmission (very rare)