White matter stuff

Question 1

kid, viral infection

Answer 1

ADEM

Question 2

Answer 2

ADEM

Question 3

Answer 3

MS

incomplete ring enhancement is strongly suggestive of MS

Question 4

Answer 4

MS

Dawson fingers: radiating periventricular white matter lesions

Question 5

Answer 5

MS; tumefactive demyelination

Question 7

31 yoF

Answer 7

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)

lacunar and subcortical white-matter strokes and vascular dementia in younger patients.

It is an autosomal dominant disorder (NOTCH3 gene).

Question 8

CADASIL inheritance

Answer 8

It is an autosomal dominant disorder (NOTCH3 gene).

mutation results in stenosis of small to medium perforating vessels and causes fibrotic thickening of the basement membranes with deposition of granular osmiophilic material around vascular smooth muscles.

Question 9

CADASIL clinical picture

Answer 9

Symptoms first occur in the third and fourth decades and typically include recurrent transient ischemic attacks (TIA) and strokes across multiple vascular territories.

Question 10

Answer 10

Alexander disease

• confluent bilateral cerebral white matter signal(anterior slightly greater than posterior),
• periventricular, subcortical, and deep white matter.
• T2/(FLAIR) hyperintensity within the bilateral basal ganglia and thalami.

Question 11

Answer 11

PKAN

Question 12

Answer 12

metachromatic leukodystrophy

tigroid

Question 13

Answer 13

adrenoleukodystrophy

Question 14

macrocephaly

Answer 14

Canavan

Question 15

Answer 15

adrenoleukodystrophy

Question 16

Answer 16

krabbe disease

Question 17

Answer 17

NMO

long segment involvement

Aquaporin 4

Question 18

Answer 18

MS - short segment

Question 19

Answer 19

NMO

Question 20

antibody in NMO

Answer 20

aquaporin 4

Question 21

mcdonald criteria

Answer 21