White Blood Cells Lecture Powerpoint

Question 1

General function of all leukocytes

Answer 1

Destroy or neutralize invading bacteria, fungi, or viruses

Question 2

From a multipotential hematopoietic stem cell (hemocytoblast), what are the 2 offspring it can develop into

Answer 2

• common myeloid progenitor

- common lymphoid progenitor

Question 3

From a common lymphoid progenitor, what 3 cells can arise from it?

Answer 3

• Natural killer cell
• T lymphocyte
• B lymphocyte

Question 4

From a common myeloid progenitor, what 4 cell types can arise from it?

Answer 4

• megakaryocyte
• erythroblast
• mast cell
• myeloblast

Question 5

From a myeloblast, what4 cell types can arise from it?

Answer 5

• basophil
• neutrophil
• eosinophil
• monocyte

Question 6

List the 4 phagocytes

Answer 6

• neutrophils
• monocytes (eventually macrophages and dendritic cells)
• mast cells
• B lymphocytes

Question 7

Chemotaxis

Answer 7

Movement of an organism in response to chemical stimuli

Question 8

Chemical stimuli from destruction of host cells causes blood vessels to ___

Answer 8

Vasodilate

Question 9

3 steps of neutrophil recruitment

Answer 9

• Margination (adherence to vessel wall)
• Diapedesis (sliding out of vessel)
• chemotaxis (follow the signals to the source)

Question 10

Walling off effect

Answer 10

Refers to clotting factors that block off areas where fluid has leaked to keep the pathogen from spreading to the rest of the body

Question 11

What 2 cell types live for months to years?

Answer 11

• Macrophages

- Lymphocytes

Question 12

Eosinophils are attracted to sites of allergic response because of…

Answer 12

…chemotactic factors released by mast cells and basophils

Question 13

What cell type causes the body to produce IgE?

Answer 13

Basophils

Question 14

Langerhan cells of the skin are also known as ___

Answer 14

Histiocytes (macrophages)

Question 15

Granuloma

Answer 15

Capsuled “giant cell” formed from alveolar macrophages creating calcifications in the lungs that often appear as tubercles

Question 16

What surface molecule do natural killer cells recognize?

Answer 16

MHC to distinguish infected and tumor cells from normal and uninfected cells

Question 17

Common reasons for leukocytosis (5)

Answer 17

Infection
Inflammation
Hereditary
Malignancy
Allergies

Question 18

Common reasons for Leukopenia (3)

Answer 18

• Aplastic anemia or bone marrow suppression
• chemotherapy
• HIV/AIDS

Question 19

Left shift or bandemia definition

Answer 19

Appearance of high numbers of immature wbc’s in blood recognized by presents of “bands” on their surface, indicates wbc’s being released before they have time to mature sometimes indicating serious bacterial infection or blood loss

Question 20

Treatment for leukopenia (2)

Answer 20

• Antibiiotics

- Transfusions