WHI followup: Effects of Estrogen postmenopausal with hysterectomy

Question 1

WHI followup: Effects of Estrogen postmenopausal with hysterectomy
- N, study design

Answer 1

JAMA
2004
RCT

N = 10,739
40 centres

Duration 6.8yrs

60-79yo Postmenopausal with hysterectomy – randomised to:

• CEE 0.625mg
• Placebo

Question 2

Outcomes WHI followup: Effects of Estrogen postmenopausal with hysterectomy

Answer 2

Primary

• Coronary heart Disease [no diff]
• Invasive breast CA not sig reduction[RR 0.77 - dec by 23% but p 0.06 – not sig]

Secondary:

• Stroke small INC risk [RR 1.39 – 12 more strokes/10,000]
• PE [RR 1.34 – only DVT reached stat sig – 7 more]
• CRC [no diff]
• Hip # dec [HR 0.61 – 6 fewer]
• Death [no diff]
• Global Index

Question 3

WHI followup: Effects of Estrogen postmenopausal with hysterectomy

Answer 3

Trial stopped early d.t. no CHD but stroke.

NOT recommended for chronic disease prevention in PM women