Wellington mock

Question 1

Rate limiting step glycolytic pathway

Answer 1

phosphofructokinase

Question 2

Rate limiting step electron transport chain

Answer 2

cytochrome oxidase

Question 3

Reversible ischaemic injury is characterised by

Answer 3

potassium efflux from cells due with failure of the sodium pump

Question 4

Peak action salbutamol

Answer 4

15-30m
duration 4-6h
Half life 4h

Question 5

Peak effect ipratropium

Answer 5

30-60m
duration 3-6
T1/2 1.5h

Question 6

Clonidine withdrawal

Answer 6

tachycardia, restlessness, insomnia, headache, nausea, vomiting, palpitations, cardiac arrhythmia, and hypertensive encephalopathy

Question 7

Cause of nutmeg liver

Answer 7

hepatic hypoperfusion

Question 8

Genetic abnormality casing CF

Answer 8

deletions

Question 9

Epicardial arteries

Answer 9

another name for coronary arteries

Question 10

Successful immune response to HIV during the acute phase

Answer 10

development of CD8+ virus specific cytotoxic cells

Question 11

Speed in AV node

Answer 11

0.05m/s

Question 12

Cause of visceral pain

Answer 12

distention

Question 13

Smallest A nerve fibre

Answer 13

delta

Question 14

Hep B immunisation schedule

Answer 14

0, 1, 6m

Question 15

Angiotensin II AT1 effect on

Answer 15

arterioles

Question 16

2nd generation cephalosporin coverage

Answer 16

very active against gram positive cocci with added gram negative and klebsiella coverage

Question 17

Hydrogen ion secretion in the distal tubules and collecting ducts is controlled by

Answer 17

Aldosterone control of ATP driven H+ pump

Question 18

Apical membrane

Answer 18

faces lumen

Question 19

Mechanism of spironalactone

Answer 19

on mineralocorticoid receptor (not directly on ENaC)

Question 20

ENaC blocker

Answer 20

Amiloride

Question 21

Gestation ectopic pregnancy rupture

Answer 21

6 weeks

Question 22

Urine threshold for gucose

Answer 22

Threshold for urine 200
TMg 300 women 375 men (transport max)

Question 23

Glucose maximally absorbed GI

Answer 23

jejenum

Question 24

Weak acid definition

Answer 24

A neutral molecule that can reversibly dissociate an anion with a proton

Question 25

Weak base definition

Answer 25

one which doesn’t convert fully into hydroxide ions in solution (doesn’t fully dissociate)

Question 26

Synaptic vesicle sizes

Answer 26

Small clear synaptic vesicles - Neurotransmitters e.g. acetylcholine
Small dense core - catecholamines
Large dense-core vesicles - neuropeptides

Question 27

Graves ABs

Answer 27

anti-TSH receptor antibodies

Question 28

Thyroid peroxidase antibodies

Answer 28

hashimotos

Question 29

Thyroglobulin antibodies

Answer 29

associated cancer +- hashimotos

Question 30

Mechanism TCAs

Answer 30

block amine reuptake pumps at presynaptic nerve endings

Question 31

Hb dissociation curve in excercise

Answer 31

shifts to the right in tissues and left in lungs