weeks 6-10 Flashcards
What can you conclude about a neuron that contains choline acetyltransferase?
The neuron contains acetylcholine
What is the name of the acetylcholine receptor located on the heart?
Muscarinic
What type of drug would induce paralysis?
think in terms of receptors (nicotinic,muscarinic, etc.)
Nicotinic receptor antagonist
How does nicotine enhance mood and decrease appetite?
Binds to nicotinic receptors in the brain
What type of drug is used to treat motion sickness and excessive sweating?
Muscarinic receptor antagonist
Most drugs of abuse cause the release of dopamine in the:
nucleus accumbens
What drug has a high efficacy compared to other common drugs?
cocaine
What is the neural mechanism for the rewarding effects of cocaine?
Blocks dopamine and norepinephrine reuptake
Amphetamine has been used as a treatment for all the conditions below except
(options: narcolepsy, anxiety, obesity, ADHD)
anxiety
What type of drug is most effective in treating schizophrenia?
dopamine receptor antagonist
What are psychedelics structurally similar to?
serotonin
What are the hallucinogenic effects of psychedelic drugs attributed to?
binding affinity to serotonergic 5-HT2A receptors
Which opioid receptor is most closely associated with opioid abuse?
mu-opioid receptor
Based on receptor binding, which endogenous opioid is most closely associated with analgesia?
beta-endorphin
What is the rewarding effect of morphine caused by?
dopamine release in the nucleus accumbens
What type of drug is used to reverse an opioid overdose?
opioid receptor antagonists
Why is it so difficult for someone addicted to opioids to stop using?
Withdrawal symptoms such as aches and pains, diarrhea, and insomnia are severe
What do most drugs classified as depressants bind to?
The allosteric site on GABA receptors
What were barbiturates historically NOT used to treat?
(anxiety, epilepsy, insomnia, bipolar)
bipolar
Inhalants are classified as depressants because many of them are:
Positive allosteric modulators of GABA receptors
Why did benzodiazepines replace barbiturates as the preferred sedative-hypnotic drug?
because they do not cause respiratory depression
What is the safest drug to prescribe for someone who suffers from insomnia?
non-benzodiazepines
