Weeks 5 & 6: Oncology Overview Flashcards
definition of cancer?
group of disease characterized by uncontrolled growth & spread of abnormal cells
definition of proto-oncogenes
genetic portion of DNA that regulates normal cell growth & repair
definition of tumor suppressor genes
genetic portion of DNA that stops, inhibits or suppresses cell division.
may also inhibit formation of cancers
mutation and loss of this function may allow cells to proliferate beyond normal body needs
most common mutated tumor suppressor gene?
p53
oncogenes?
altered forms of normal proto-oncogenes
interfere with normal cell growth, differentiation, apoptosis
risk factor for cancer
tobacco
alcohol
diet high in fat
UV radiation (dependent on latitude, altitude, humidity & personal behaviors)
ionizing radiation (miners & Hiroshima)
chemicals & other substances - asbestos
close relatives with certain types of cancer genetic predisposition
hormone replacement therapy
age (length of time exposed to cancer inducing agents & natural decline in immune system)
virus: HPV, Hep B
modifiable risk factors for cancer
tobacco alcohol overweight/obesity physical inactivity low fruit/vegetable consumption unsafe sex urban air pollution indoor smoke from household fuels contaminated injections in health care setting
signs & symptoms of cancer
local symptoms: unusual lumps/swelling; hemorrhage; pain and/or ulcerations; compression of surrounding tissues or obstruction (jaundice)
systemic symptoms: weight loss; poor appetite; cachexia; excessive sweating (night sweats); paraneoplastic phenomena
7 warning signals for cancer
- change in bowel/bladder habits
- unusual bleeding/discharge
- sore that doesn’t heal
- obvious change in a wart/mole
- thickening/lump in breast or elsewhere
- nagging cough or hoarseness
- indigestion/difficulty swallowing
definition of angiogenesis
the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients, oxygen and removing waste products. this process is necessary for tumor growth & spread
carcinogenesis?
multi-step process by which a normal cell is transformed into a malignancy
INITIATION: a carcinogen causes a genetic change or damage to the DNA in a normal cell
PROMOTION: an initiated cell is exposed to an agent that enhances its growth into a larger mass
PROGRESSION: metastatic spread via circulatory and lymphatic systems.
metastasis?
spread of cancer cells from a primary tumor to a distant site in the body
how can cancer cells spread?
direct invasion
seeding throughout a body cavity
dissemination via lymphatic system
dissemination via circulatory system
incisional biopsy?
aspiration, fine needle, core sentinel lymph node
what is a sentinel lymph node?
where the injected tracer goes first after injection
excision biopsy?
removal of tissue
cytology biopsy?
exam of fluid containing cells
prostate cancer tumor marker
PSA
ovarian cancer tumor marker
CA 125
colorectal cancer tumor marker
CEA
primary liver/germ cell tumor marker
alpha fetoprotein
choriocarcinoma/pancreas cancer tumor marker
HCG
pancreas/stomach cancer tumor marker
CA 19-9
most cancers tumor marker
LDH
small cell lung cancer tumor marker
neuron specific enolase
what is TNM staging?
most common way to stage cancer
T-tumor
N-nodes
M-metastasis
T in TNM staging
Tx: primary tumor cannot be evaluated
To: no evidence of primary tumor
Tis: carcinoma in situ (early cancer that has not spread to the neighboring tissue)
T1, T2, T3, T4: size and/or extent of the primary tumor
N in TNM staging
regional lymph node
Nx: regional lymph nodes cannot be evaluated
N0: no regional lymph node involvement (no cancer found in the lymph nodes)
N1, N2, N3: involvement of regional lymph nodes (number and/or extent of spread)
M in TNM staging
distant metastasis
Mx: distant metastasis cannot be evaluated
M0: no distant metastasis (cancer has not spread to other parts of the body)
M1: distant metastasis (cancer has spread distant parts of the body)
stage 0 definition
carcinoma in situ
early cancer that is present only in the layer of cells in which it began
stage I, II, III definition
higher numbers indicate more extensive disease: greater tumor size and/or spread of the cancer to nearby lymph nodes and/or organs adjacent to the primary tumor
stage IV definition
the cancer has spread to another organ
primary treatment?
major modality used to treat a cancer
adjuvant therapy
therapy given after the primary treatment to control potential or known sites of metastasis
me-adjuvant treatment
therapy given before the primary treatment to control potential or known sits of metastasis
goal of therapy: cure
eradication of tumor cels
goal of therapy: control
containment of the growth of cancer cells without complete eradication
goal of therapy: palliation
comfort and relief of symptoms when cure is no longer possible
goal of therapy: reconstruction
to return an individual to his/her optimum functional status
types of cancer treatment modalities
surgery radiotherapy chemotherapy hormone therapy immunotherapy biotherapy molecular targeted therapy gene therapy nanobiotherapy
eco performance status?
eastern cooperative oncology group
0: fully active, able to carry on all pre-disease performance without restriction
1: restricted in physically strenuous activity by ambulatory and able to carry out work of a light or sedentary nature (light house work, office work)
2: ambulatory and capable of all self care but unable to carry out any work activities. up and about more than 50% of waking hours
3. capable of only limited self care, confined to bed or chair more than 50% of waking hours
4. completely disabled. cannot carry on any self care. totally confined to bed or chair
5. dead
karnofsky performance status score
100: normal: no complaints, no evidence of disease
90: able to carry on normal activity; minor symptoms
80: normal activity with effort; some symptoms
70: cares for self; unable to carry on normal activities
60: requires occasional assistance; cares for most needs
50: requires considerable assistance and frequent care
40: disabled: requires special care and assistance
30: severely disabled: hospitalized but death not imminent
20: very sick: active supportive care needed
10: moribund: fatal processes are progressing rapidly
0: dead