week3 competencies only

Question 1

which cox is responsible for : bleeding tendencies and gastic muscoal damage?

Answer 1

cox-1

Question 1

which OD of this analgesic is responsible for Compensated respiratory alkalosis then respiratory depression acidosis?

Answer 1

Aspirin

Question 1

The OD A/E: Hepatic Necrosis, Hepatic Failure, coma, death… are common with this Rx

Answer 1

Acetaminophen (Tylenol)

Question 2

which OD of this analgesic requires Tx such as : mechanical ventilation, external cooling, IV fluids, ACTIVATED Charcoal, bicarb, dyalisis

Answer 2

Aspirin

Question 4

These OD side affects: N/V/D, sweating, diarrhea and abdominal discomfort, are common with this drug…

Answer 4

Acetaminophen (Tylenol)

Question 6

which OD of this analgesic is responsible for a/e of stupor coma resp failure and even death

Answer 6

aspirin

Question 7

which cox is responsible for : analgesia and anitinflammatory activity

Answer 7

cox-2

Question 8

describe the main therapeutic uses of glucocorticoids for non-endocrine disorders

Answer 8

RA,Lupus, inflam bowel disease, inflam disorders, allergic reactions, sskin disorders, astham neoplasmas, supress organ rejection, prevent resp. distress syndrome in premature infants

Question 10

Acetaminophen (Tylenol) s/e from OD are

Answer 10

N/V/D, sweating, and abdominal discomfort

Question 11

which analgesic is responsible for these A/E’s after an OD : of hyperthermia, sweating, dehydration, electrolyte imbalance

Answer 11

aspirin

Question 12

This is the Tx for Acetaminophen OD

Answer 12

ACETYLCUSTEINE (MUCUMYST) must give PO or IV within 8-10 after overdose

Question 14

describe the appropriate discontinuation process of systemic glucocorticoids

Answer 14

slowly tapper off 7days

switch from multiple to singel dose

wean of drug-if abrupt stop-then CRISIS

withdrawl syndrome s/s: hypotension, myalgia ,arthralgia, fatigue

Question 15

adverse effects of nsaids(aspirin, ibuprofen, celecoxib) are….

Answer 15

H/a,Drowziness, diziness,

Gi distress/bleeding,periph edema

Question 16

Glucocorticoids-prednisone, predniSOLONE

S/E

Answer 16

euphoria,confusion, psychosis,H/A,insomnia,osteoperosis,

GI distress,gastric ulceration,

delayed wound healing, hyperglycemia

Question 17

S/E of DMARDS-methotrexate(Rheumatrex), Sulfasalazine

Answer 17

H/A, infex, bone marrow supression,

hepatoxicity, pneumonitis, gi ulcer, glossitis, gingivitis, stomatitis, leukopenia, thrombocytopenia.increased deaths from CV disease, CA, fetal abnormalities and death.

Question 18

S/E’s of DMARDS-Tumor necrosis factor (TNF) antagonists: etanercept(Enbrel).infliximab (remicade, adalimumab(Humira)

Answer 18

• serious Tb infex
• HF,MI,CA,Liver Dysfunx
• MS, panocytopenia
• H/a, Diziness, Rhinitis, cough,abd pain
• injecx site reacx, itching,
• erythema,swelling, pain

Question 19

A/E’s of a DMARD-B Lymphocyte depleting agents: rituximab(Rituxan)

Answer 19

• Ftg/Fvr/ chills/ flushing
• N/V anorexia, abd pain
• Fatal infusion reacx:HypoTN,bronchospasm, angioedema, MI, cardiogenic shock.
• Dermatitis,Steven Johns Syndrome
• Hepatitis B reactivation
• Neutropenia, leukopenia, anemia, thrombocytopenia

Question 20

A/E’s of DMARD-T-Cell activation inhibitors

Abatacept(Orencia)

Answer 20

• Headache, URI,nausea
• Increases risk of serious infection and cancer

Question 21

A/E’s of JANUS KINASE (JAK) INHIBITORS

tofacitinib (Xeljanz)

Answer 21

• increased risk of serious infections tb, cancers, and lymphoma as well as high cholesterol, respiratory tract infections, H/A, Diarrhea

Question 22

Describe action and A/E of

NSAIDS

indomethacin (Indocin), Naproxen(naprosyn), diclofenac (Voltaren)

Answer 22

• first DOC for acoute gouty arthritis
• better tolerated than colchecine, effects more predictable
• beneficial effects-supress inflamation
• relief w/in 24 hrs

Question 23

Describe action and A/E of

HYPERURICEMICS-allopurinol (Zyloprim)

Answer 23

• DOC in ULT
• Action-inhibits uric acide formation and prevents tophus formation, causes tophi resression
• A/Es are fatal hypersensitivity syndrome
• Gi distress
• neruologic effects
• may cause cataracts

Question 24

Action and A/E’s

probenecid (generic only)

Answer 24

action: inhibits reabsorption or uric acid in renal tubules

A/E: Gi effects, hypersensitivity reacx, renal injury

Question 25

what are Colchicine's action and A/E's?

Answer 25

Action: anti inflammatory specific to gout A/E: N/V/D/abdPain * D/C drug when Gi symptoms develop * bone marrow supression * rhabdomyolosis

Question 26

Describe drug therapy for osteoperosis using calcitonin-Salmon(miacalcin, fortical) Action and A/E:

Answer 26

* inhibits osteoclastic activity by decreasing bone resorption and increases calcium excretion * A/E: nasal druness and irritation * nausea, flushing oif face and hands * inflammatory injection site reacx

Question 27

describe drug therapy for osteoperosis using such drugs as: Biophosphonates-**alendronate(Fosamax)**, ibanddronate (Boniva)-PO ACTION and A/E:

Answer 27

* muscular skeletal pain * occular inflamax, esophatitis * osteonecrosis of jaw, femur fractures * Hyperparathyroidism, A-Fib

Question 28

describe drug therapy for osteoperosis using such drugs as: Selective Estrogen receptor modulators(SERM's)-raloxifine (EVISTA)-PO ACTION and A/E:

Answer 28

* Action: bond to estrogen receptors selectivly * Mimics estrogen effects on bone, lipid metabolism, blood clotting, blocks estrogen effects in breast and endometrium * A/E: venous thromboembolism, hot flashes, fetal harm

Question 29

describe drug therapy for osteoperosis using such drugs as:Teriparatide (Forteo)-given daily subq ACTION and A/E:

Answer 29

* ACTION: only approved drug to increase bone formation in osteoperosis * A/E: N/HA, back pain, leg cramps, orthostatic hypotension, dizziness, bone cancer * elevated levels of Calcium, mg, uric acid

Question 30

describe drug therapy for osteoperosis using such drugs as: Monoclonal decreases osteoclast formation and funcx (Rankl inhibitor) ACTION and A/E:

Answer 30

* A/E: pain in back and extremeties * hypercholesterolemia * urinary bladder infecx * hypercalcemia, serious infex * Rashes, osteonecrosis of jaw