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2015 S.U. Pharm II > week3 competencies only > Flashcards

week3 competencies only Flashcards

1
Q

which cox is responsible for : bleeding tendencies and gastic muscoal damage?

A

cox-1

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1
Q

which OD of this analgesic is responsible for Compensated respiratory alkalosis then respiratory depression acidosis?

A

Aspirin

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1
Q

The OD A/E: Hepatic Necrosis, Hepatic Failure, coma, death… are common with this Rx

A

Acetaminophen (Tylenol)

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2
Q

which OD of this analgesic requires Tx such as : mechanical ventilation, external cooling, IV fluids, ACTIVATED Charcoal, bicarb, dyalisis

A

Aspirin

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3
Q
A
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4
Q

These OD side affects: N/V/D, sweating, diarrhea and abdominal discomfort, are common with this drug…

A

Acetaminophen (Tylenol)

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6
Q

which OD of this analgesic is responsible for a/e of stupor coma resp failure and even death

A

aspirin

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7
Q

which cox is responsible for : analgesia and anitinflammatory activity

A

cox-2

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8
Q

describe the main therapeutic uses of glucocorticoids for non-endocrine disorders

A

RA,Lupus, inflam bowel disease, inflam disorders, allergic reactions, sskin disorders, astham neoplasmas, supress organ rejection, prevent resp. distress syndrome in premature infants

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10
Q

Acetaminophen (Tylenol) s/e from OD are

A

N/V/D, sweating, and abdominal discomfort

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11
Q

which analgesic is responsible for these A/E’s after an OD : of hyperthermia, sweating, dehydration, electrolyte imbalance

A

aspirin

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12
Q

This is the Tx for Acetaminophen OD

A

ACETYLCUSTEINE (MUCUMYST) must give PO or IV within 8-10 after overdose

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13
Q
A
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14
Q

describe the appropriate discontinuation process of systemic glucocorticoids

A

slowly tapper off 7days

switch from multiple to singel dose

wean of drug-if abrupt stop-then CRISIS

withdrawl syndrome s/s: hypotension, myalgia ,arthralgia, fatigue

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15
Q

adverse effects of nsaids(aspirin, ibuprofen, celecoxib) are….

A

H/a,Drowziness, diziness,

Gi distress/bleeding,periph edema

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16
Q

Glucocorticoids-prednisone, predniSOLONE

S/E

A

euphoria,confusion, psychosis,H/A,insomnia,osteoperosis,

GI distress,gastric ulceration,

delayed wound healing, hyperglycemia

17
Q

S/E of DMARDS-methotrexate(Rheumatrex), Sulfasalazine

A

H/A, infex, bone marrow supression,

hepatoxicity, pneumonitis, gi ulcer, glossitis, gingivitis, stomatitis, leukopenia, thrombocytopenia.increased deaths from CV disease, CA, fetal abnormalities and death.

18
Q

S/E’s of DMARDS-Tumor necrosis factor (TNF) antagonists: etanercept(Enbrel).infliximab (remicade, adalimumab(Humira)

A
  • serious Tb infex
  • HF,MI,CA,Liver Dysfunx
  • MS, panocytopenia
  • H/a, Diziness, Rhinitis, cough,abd pain
  • injecx site reacx, itching,
  • erythema,swelling, pain
19
Q

A/E’s of a DMARD-B Lymphocyte depleting agents: rituximab(Rituxan)

A
  • Ftg/Fvr/ chills/ flushing
  • N/V anorexia, abd pain
  • Fatal infusion reacx:HypoTN,bronchospasm, angioedema, MI, cardiogenic shock.
  • Dermatitis,Steven Johns Syndrome
  • Hepatitis B reactivation
  • Neutropenia, leukopenia, anemia, thrombocytopenia
20
Q

A/E’s of DMARD-T-Cell activation inhibitors

Abatacept(Orencia)

A
  • Headache, URI,nausea
  • Increases risk of serious infection and cancer
21
Q

A/E’s of JANUS KINASE (JAK) INHIBITORS

tofacitinib (Xeljanz)

A
  • increased risk of serious infections tb, cancers, and lymphoma as well as high cholesterol, respiratory tract infections, H/A, Diarrhea
22
Q

Describe action and A/E of

NSAIDS

indomethacin (Indocin), Naproxen(naprosyn), diclofenac (Voltaren)

A
  • first DOC for acoute gouty arthritis
  • better tolerated than colchecine, effects more predictable
  • beneficial effects-supress inflamation
  • relief w/in 24 hrs
23
Q

Describe action and A/E of

HYPERURICEMICS-allopurinol (Zyloprim)

A
  • DOC in ULT
  • Action-inhibits uric acide formation and prevents tophus formation, causes tophi resression
  • A/Es are fatal hypersensitivity syndrome
  • Gi distress
  • neruologic effects
  • may cause cataracts
24
Q

Action and A/E’s

probenecid (generic only)

A

action: inhibits reabsorption or uric acid in renal tubules

A/E: Gi effects, hypersensitivity reacx, renal injury

25
Q

what are Colchicine’s action and A/E’s?

A

Action: anti inflammatory specific to gout

A/E: N/V/D/abdPain

  • D/C drug when Gi symptoms develop
  • bone marrow supression
  • rhabdomyolosis
26
Q

Describe drug therapy for osteoperosis using

calcitonin-Salmon(miacalcin, fortical)

Action and A/E:

A
  • inhibits osteoclastic activity by decreasing bone resorption and increases calcium excretion
  • A/E: nasal druness and irritation
  • nausea, flushing oif face and hands
  • inflammatory injection site reacx
27
Q

describe drug therapy for osteoperosis using such drugs as: Biophosphonates-alendronate(Fosamax), ibanddronate (Boniva)-PO

ACTION and A/E:

A
  • muscular skeletal pain
  • occular inflamax, esophatitis
  • osteonecrosis of jaw, femur fractures
  • Hyperparathyroidism, A-Fib
28
Q

describe drug therapy for osteoperosis using such drugs as: Selective Estrogen receptor modulators(SERM’s)-raloxifine (EVISTA)-PO

ACTION and A/E:

A
  • Action: bond to estrogen receptors selectivly
  • Mimics estrogen effects on bone, lipid metabolism, blood clotting, blocks estrogen effects in breast and endometrium
  • A/E: venous thromboembolism, hot flashes, fetal harm
29
Q

describe drug therapy for osteoperosis using such drugs as:Teriparatide (Forteo)-given daily subq

ACTION and A/E:

A
  • ACTION: only approved drug to increase bone formation in osteoperosis
  • A/E: N/HA, back pain, leg cramps, orthostatic hypotension, dizziness, bone cancer
  • elevated levels of Calcium, mg, uric acid
30
Q

describe drug therapy for osteoperosis using such drugs as: Monoclonal decreases osteoclast formation and funcx (Rankl inhibitor)

ACTION and A/E:

A
  • A/E: pain in back and extremeties
  • hypercholesterolemia
  • urinary bladder infecx
  • hypercalcemia, serious infex
  • Rashes, osteonecrosis of jaw
31
Q
A

2015 S.U. Pharm II (5 decks)

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