Week Nine - Molecular Imaging & Modelling

Question 1

What is anatomical imaging?

Answer 1

Provides detailed visualisation of anatomical boundaries. X-ray, CT, MRI.

Question 2

What is molecular imaging?

Answer 2

Functional imaging that allows you to visualise of physiological processes at a molecular level. PET, SPECT, fMRI

Question 3

What are the three compartments involved in the kinetic model of FDG?

Answer 3

1. FDG in plasma (Cp)
2. FDG in tissue (Ce)
3. FDG-6-PO4 in tissue (Cm)

Question 4

What does k1 stand for?

Answer 4

Rate constant of FDG forward transcapillary membrane transport.

Question 5

What does k2 stand for?

Answer 5

Rate constant of FDG reverse transcapillary membrane.

Question 6

What does k3 stand for?

Answer 6

Rate constant of FDG phosphorylation.

Question 7

What does k4 stand for?

Answer 7

Rate constant of FDG dephosphorylation (normally assumed to be zero)

Question 8

What does k1 = 0.1/min mean?

Answer 8

10% of FDG is transported from plasma into tissue per minute.

Question 9

What is the formula for the cerebral metabolic rate of glucose consumption?

Answer 9

CMRGlc = (1/LC)(k1k3/(k2+k3))(Cglu)