Week 9: Neoplasia 2

Question 1

A tumour is formed by __________________ of a single precursor cell that has incurred ____________.

Answer 1

Clonal Expansion

Genetic Damage

Question 2

What are 4 main classes of genes affected?

Answer 2

Proto-oncogenes
Tumour Suppressor Genes
Apoptosis Regulating Genes
DNA Repair genes

Question 3

What causes Carcinogenesis?

Answer 3

The accumulation of mutations over time in a stepwise fashion

Question 4

What are driver mutations?

Answer 4

Mutations that contribute to the development of a malignant phenotype

Question 5

What are passenger mutations?

Answer 5

Loss of function mutations that maintain genomic integrity and can lead to more mutations that have no phenotypic consequence

Question 6

What are Proto-Oncogenes

Answer 6

A normal gene whose products promote cell proliferation that can undergo mutations to become an oncogene

Question 7

What are Oncogenes?

Answer 7

• A gene that has the potential to cause cancer

- They function autonomously and have lost dependence on normal growth promoting signals

Question 8

What are Oncoproteins?

Answer 8

A protein encoded by an oncogene that drives increased cell proliferation