Week 8 Part 2 Flashcards
What’s peripheral arterial disease?
Narrowing of the arteries supplying the limbs and periphery , reducing blood supply to said areas.
Results in symptoms of claudication
What’s intermittent claudication?
A symptom of ischaemia in the limb
Occurring during exercise and relived by rest. Crampy, achy pain
What’s claudication
Pain in buttocks, thigh, calf when you walk
Known as symptom of peripheral arterial disease
Due to narrowed or blocked arteries
What’s critical limb ischaemia
End stage of peripheral arterial disease
Inadequate supply of blood to a limb to allow it to function normally at rest
Features of critical limb ischaemia
Pain at rest
Non healing ulcers
Gangrene
Could lose limb
Why might acute limb ischaemia occur?
Perhaps due to rapid onset of ischaemia in a limb
Typically due to thrombus or a clot blocking the arterial supply of a distal limb eg limb version of heart attach
Why is acute limb ischaemia like limb version of heart attack
Often due to thrombus blocking supplies of blood to a limb
Gangrene vs necrosis
Gangrene is necrosis because of inadequate blood supply
What’s atherosclerosis
Fatty deposits in blood vessels walal
What’s deposited in atherosclerosis
Lipids, then fibrous atheromatous plaques are developed
What do the plaques cause in atherosclerosis??????????? (3)
Stiffening of walls therefore hypertension and therefore strain on heart
Stenosis eg in angina
Plaque rupture = thrombosis and therefore ischaemia
Why would stiffening of walls in atherosclerosis lead to strain on heart
Stiffening of walls therefore hypertension and therefore strain on heart
Taking a history: what risk factors to think of for atherosclerosis???
Smoking
Alcohol
Poor diet
Low exercise
Obesity
Poor sleep
Stress
Atherosclerosis: diabetes, hypertension, chronic kidney, inflammatory like rheumatoid arthritis … what’s the connection
These are all medical co morbidities
Could angina be an end result of atherosclerosis?
Yah
Peripheral arterial disease could be an end result if what
Atherosclerosis
Chronic mesenteric ischaemia could be an end result of what
Atherosclerosis
TIA can be caused by atherosclerosis
Yah
Features of critical limb ischaemia can be remembered with the 6 p’s mnemonic
Pain
Pallor
Pulseless
Paralysis
Paraesthesia
Perishing cold
What’s paraesthesia
Pins and needles
When is the pain worse in critical limb ischaemia
Worse at night cuz gravity doesn’t pull blood into the foir
What’s the pain like in critical limb ischaemia
Burning pain
What might a scar on the inner calf show?
For saphenous vein harvesting (previous CABG)
What’s a hand held Doppler for
To accurately asses the pulse when they are difficult to palpate
Poor wound healing could be a sign of arterial disease
Ya
As well as ulcers
Muscle wastage could be a sign of arterial disease on inspection
Yah
Cyanosis is a sign of arterial disease
Ywha
Prolonged capillary time could be a sign of arterial disease
Yah
What’s buergers test for
Assessing for peripheral arterial disease in the leg
Explain the two parts of buerger’s test
1st part) lie patient down. Lift legs 45’.hold for 2 mins. Look for pallor. = can’t overcome gravity. State buergers angle - that legs go pale
2nd part) hang legs. Legs should go normal. If peripheral arterial disease = blue as ischaemic tissue deoxygenated the blood
Dark red due to vasodilation in response to waste products of anaerobic respiration
Colour check of buergers test meaning??
hang legs. Legs should go normal. If peripheral arterial disease = blue as ischaemic tissue deoxygenated the blood
Dark red due to vasodilation in response to waste products of anaerobic respiration
What do leg ulcers indicate especially in peripheral arterial disease
Indicate the skin and tissues are struggling to heal due to impaired blood flow…
Arterial ulcers due to:
Venous ulcers due to:
Arterial ulcers: due to ischaemia secondary to an inadequate blood supply
Venous ulcers are due to: impaired drainage and pooling of blood in the legs
Which are smaller, arterial or venous ulcers
Arterial usually. Also usually deeper
Which are less painful, arterial or venous ulcers?
Venous
Why use angiography (CT or MRI)
To use contrast to highlight arterial circulation
What do statins do
Lower cholesterol
Why atorvastatin for intermittent claudication?
Reduces cholesterol
Why clopidogrel for intermittent claudication?
It’s an anti-platelet
What’s aspirin
Non steroidal anti inflammatory drug used to reduce pain fever
Also antithrombotic
Why bypass surgery for intermittent claudication?
Using a graft to bypass the blockage
What’s an endarterectomy and why intermittent claudication?
Cutting vessel open and removing the atheromatous plaque
Surgical option for intermittent claudication???
Endovascular angioplasty and stenting
Patients with critical limb ischaemia need what to manage the pain
Analgesia
If a patient has a hole in their heart eg atrial septal defect, what can a blood clot do
Pass into systemic circulation, and maybe travel to brain and cause a stroke
We know several factors can lead to DVT, so what do we do
Give prophylactic treatment
Eg surgery
I’d malignancy a risk factor for dvt
Yah
If a patient presents with possible features of DVT or PE, what risk factors could we ask about?
Periods of immobility, surgery, and long haul flights
What’s a common prophylaxis for venous thromboembolism?
Low molecular weight heparin
Main contraindication to anti embolus compression stockings is what
Significant peripheral arterial disease
DVTs are usually bilateral
False
Unilateral
Bilateral symptoms of DVT are what
Usually more likely to be
Chronic venous insufficiency or heart failure
DVT presentation?
Calf or leg swelling
Dilated superficial veins
Tenderness to the calf
Oedema
Colour changes to da legs
DVT could make you suspicious of what?
Pulmonary embokism
What’s a wells score?
Predicts risk of patient presenting with symptoms of DVT or PE
D dimer is a sensitive test useful for excluding what
Venous thromboembolism
Pneumonia could raise a d dimer
Yes
Malignancy could raise a d dimer
Heart failure could raise a d dimer
Yrs
Surgery could raise a d dimer
Yes
Pregnancy could raise a d dimer
Yes
What’s the initial management for suspected or confirmed DVT or PE?
Anticoagulatiooooon
Start immediately
What’s the recommended first management for PE or DVT with the name???
Anticoagulant
Ends in ‘ban’ eg apixaban or rivaroxaban
Example for long term anti coagulation for VTE???? (2)
Warfarin
DOAC
What’s DOAC??
Direct oral anticoagulants
Example of DOAC
Ending with ban
Eg apixaban
What is warfarin?
A vitamin K antagonist