Week 8 - Guanylyl Cyclase Coupled Receptor

Question 1

What is EDRF?

Answer 1

• Endothelium-Derived Relaxing Factor
• released by vascular endothelium
• responding to ACh
• relaxes smooth muscle

Question 2

How is nitric oxide released?

Answer 2

• acetylcholine
• bradykinin
• substance P
• binds to receptor on generator cell
• second messenger activates NO synthase
• converts L-arginine to NO
• NOS can be inhibited by L-NMMA
• NO activates sGC
• sGC converts GTP to cGMP

Question 3

What are the isoforms of NOS

Answer 3

• neuronal
• inducible
• endothelial

Question 4

What is sGC?

Answer 4

• soluble Guanylyl Cyclase
• responsible for majority of NO physiological actions