Week 8 - Complement Pathway Flashcards
1
Q
Complement is a series of more than?
A
30 soluble and cell-bound proteins
2
Q
Complement pathway is heat labile, true or false?
A
True
3
Q
He termed “complement” by year 1980’s
A
Paul Erlich
4
Q
In year 1919, he was awarded a Noble Prize for elucidating the nature of complement.
A
Jules Bordet
5
Q
Complement activation promotes 3 components, what are those?
A
- activation of immune system
- opsonization (C3b, C4b, and C5b)
- lysis of foreign cells and immune complexes
6
Q
Chronic activation leads to?
A
Inflammation and tissue damage
7
Q
Opsonization enhance?
A
Phagocytosis or cell eating
8
Q
Response time and normal concentration of C-reactive protein?
A
6-10 hours, 0.5 mg/dL
