Week 8 - chronic diseases Flashcards
What are carbohydrates? (LO1)
- The most abundant organic molecule.
- Energy souce (glucose –> ATP).
- Energy storage (glycogen).
- Structural component.
- Immune function.
- Intracellular communication.
Describe the general classification and structure of carbohydrates. (LO1)
- Carbo = carbon.
- Hydrate = water.
- General formula is (CH₂O)n
- Monosaccharide = 1 sugar unit.
- Disaccharide = 2 sugar units.
- Oligosaccharide = 3-10 sugar units.
- Polysaccharides = 11- >100 sugar units.
Describe the classification of carbohydrates by the number of carbon atoms. (LO1)
- Triose = 3 carbons, e.g. glyceraldehyde.
- Tetrose = 4 carbons, e.g. erythrose.
- Pentose = 5 carbons, e.g. ribose.
- Hexose = 6 carbons, e.g. glucose.
- Heptose = 7 carbons, e.g. sedoheptulose.
- Nonose = 9 carbons, e.g. neuraminic acid.
Describe the classification of carbohydrates by functional group. (LO1)
The most common functional groups are aldehydes (O=C-H) or ketones (C=O).
- Monosaccharides + aldehyde function = aldoses (suffix -ose).
- Monosaccharides + ketone function = ketoses (suffix -ulose).
- Hexose + aldehyde function = ALDOHEXOSE.
- Hexose + ketone function = KETOHEXOSE.
N.B. ketohexose is also known as fructose (it should be called fructulose but some idiot decided to make things confusing).
Describe the classification of carbohydrates by structure. (LO1)
- Compounds that have the same chemical formula, but different structures are called isomers.
- Carbohydrate isomers which only differ around one specific carbon atom are called epimers.
What are enantiomers? (LO1)
- Pairs of structures that are mirror images of each other.
- Even if you rotate one mirror image, the molecules still do not superimpose on each other.
What is meant by L and D designations? (LO1)
- These designations are based on the configuration of a single asymmetric carbon atom in glyceraldehyde.
- Sugars with >1 chiral centre.
- D and L refer to the farthest asymmetric carbon atom from the carbonyl group.
- Most naturally occurring sugars are D isomers.
Describe the cyclisation of monosaccharides. (LO1)
> 99% of monosaccharides with >5 carbon atoms form a ring structure.
- To form this, the aldehyde/ketone group reacts with the hydroxyl group of the same monosaccharide.
- 5 carbon atoms + 1 oxygen atom = PYRANOSE RING.
- 4 carbon atoms + 1 oxygen atom = FURANOSE RING.
How does cyclisation of monosaccharides change them? (LO1)
- Creates a new stereogenic centre (also known as chiral centre).
- The chiral centre becomes asymmetric.
- In D-glucose, the newly generated hydroxyl group can be above or below the midplane of the cyclised molecule. Thus, the open chain monosaccharide yields two cyclic isomers: α-anomer and β-anomer.
- In glucose, the full names of these molecules are α-D-glycopyranose and β-D-glucopyranose.
- Both anomers of the sugar are in equilibrium in solution and can spontaneously interconvert.
- This process is called mutarotation and can take hours.
- In glucose, the ratio is 64:36 of β:α.
What is the chiral centre? (LO1)
The carbon atom bearing the carbonyl.
Give three examples of monosaccharides and their sources. (LO1)
- Glucose.
- Primary energy source: preferred energy source for the brain, required energy source for cells with few/no mitochondria, essential in exercising muscles.
- Source: diet, degradation of glycogen, gluconeogenesis. - Fructose.
- Sweeter than glucose.
- Source: fruits, vegetables, honey. - Galactose.
- Less sweet than glucose.
- Source: dairy products.
Give three examples of disaccharides. How are they made? (LO1)
- Sucrose = glucose + fructose.
- Maltose = glucose + glucose.
- Lactose = glucose + galactose.
Describe the disaccharide bond between glucose and fructose in sucrose. (LO1)
- Glycosidic bonds.
- These bonds are named according to the numbers of the connected carbon atoms and the position of the anomeric hydroxyl groups involved in the bond.
- E.g. if the hydroxyl group is in α-configuration, then it’s an α-bond.
- In sucrose: α-(1–>2)-β-glycosidic bond.
- This means that the hydroxyl group of carbon atom 1 in α-configuration has reacted with the hydroxyl group of carbon atom 2 in β-configuration.
- This reaction leads to the elimination of one water molecule.
- Scientific name of sucrose: α-D-glucopyranosyl-(1–>2)-β-D-fructofuranoside.
Describe the bond between the two glucose molecules in maltose. (LO1)
- α-(1–>4)-glycosidic bond.
- The hydroxyl group on carbon atom 1 on one glucose molecule in α-configuration reacts with the hydroxyl group on carbon atom 4 of another glucose molecule to form a bond between them by the elemination of one water molecule.
- Scientific name of maltose: α-D-glucopyranosyl-(1–>4)-β-D-fructofuranoside.
Describe the bond between glucose and galactose in lactose. (LO1)
- β-(1–>4)-glycosidic bond.
- The hydroxyl group on carbon atom 1 of galactose in β-configuration reacts with the hydroxyl group on carbon atom 4 of glucose to form the bond between them by the elimination of one water molecule.
Give three examples of polysaccharides and their functions. (LO1)
- Cellulose - structural.
- Starch - storage (plants).
- Glycogen - storage (animals).
What is cellulose? (LO1)
- Polysaccharide consisting of a linear chain of 100,000s of β-glucose units.
- Glucose molecules linked together by β-(1–>4)-glycosidic bonds.
- Cellulose is an important component of dietary fibre which acts as a hydrophilic bulking agent for the faeces.
- Major component of plant cell walls.
What is starch? (LO1)
- Polysaccharide consisting of 100,00s of glucose units.
- Glucose molecules linked together by α-(1–>4)-glycosidic bonds.
- Found in all plant seeds and tubers.
- Amylose and amylopectin are the 2 forms of starch.
What is amylose? (LO1)
- Unbranched polymer.
- A form of starch.
- Linear polysaccharide just like cellulose.
- Glucose molecules linked together by only α-(1–>4)-glycosidic bonds.
What is amylopectin? (LO1)
- Branched polymer (every 20-30 carbon residues).
- A form of starch.
- Most glucose molecules linked by α-(1–>4)-glycosidic bonds.
- Every 20-30 residues, the glucose molecules are also linked by α-(1–>6)-glycosidic bonds which form the branches.
What is glycogen? (LO1)
- Branched polysaccharide consisting of 100,000s of glucose molecules.
- More extensively branched and compact than amylopectin.
- Similar structure to amylopectin with mainly α-(1–>4)-glycosidic bonds.
- Every 8-10 residues, the glucose molecules are also linked by α-(1–>6)-glycosidic bonds.
Describe the the three areas where carbohydrates are digested and the enzymes involved. (LO1)
- Salivary glands - alpha amylase.
- Small intestine - pancreatic α-amylase.
- Upper jejunum - dextrinase, glucoamylase (gamma amylase), isomaltase, maltase, sucrase, lactase.
How do the salivary glands aid the digestion of carbohydrates? (LO1)
- Occurs in the mouth during chewing.
- Saliva contains α-amylase which hydrolyses α-(1–>4) bonds.
- E.g. starch –> maltose + dextrin.
- Dextrin is a mixture of glucose polymers linked by α-(1–>4)-glycosidic bonds and α-(1–>6)-glycosidic bonds.
How does the small intestine aid the digestion of carbohydrates? (LO1)
- Pancreatic alpha amylase creates more maltose and dextrin.
How does the mucosal lining of the upper jejunum aid the digestion of carbohydrates? (LO1)
- Brush-border membrane-associated oligosaccharides and disaccharides hydrolyse the carbohydrates to yield glucose, fructose and galactose.
- Dextrinase is a debranching enzyme. It hydrolyses α-(1–>6)-glycosidic bonds.
- Glucoamylase (gamma amylase) hydrolyses α-(1–>6) and α-(1–>4)-glycosidic bonds, yielding glucose.
- Finally, disaccharides are hydrolysed to monosaccharides.
- Isomaltose is hydrolysed by isomaltase to yield two glucose molecules.
- Maltose is hydrolysed by maltase to yield two glucose molecules.
- Sucrose is hydrolysed by sucrase to yield glucose and fructose.
- Lactose is hydrolysed by lactase to yield glucose and galactose.
Describe the absorption of monosaccharides. (LO1)
- Monosaccharides are absorbed by intestinal mucosal cells.
- Glucose and galactose are taken up by SGLT-1 (sodium-dependent glucose co-transporter 1).
- Fructose is taken up by GLUT-5 (sodium-independent monosaccharide transporter).
- All monosaccharides are transported from the intestinal wall into the portal circulation by GLUT-2.
How does the sodium-dependent glucose transporter 1 (SGLT-1) work to absorb carbohydrates? (LO1)
- SGLT-1 (sodium-dependent glucose co-transporter 1) - take up glucose and galactose. This is an active transporter.
- Glucose and galactose are taken up together with sodium ions.
- This uptake is dependent on the existing sodium gradient.
- The sodium gradient is achieved through the action of an ATP-dependent sodium-potassium pump which expels 3 sodium ions from the cell in exchange for 2 potassium ions entering the cell.
How do we manage sugar intolerance? (LO1)
- Dietary avoidance of sugar.
- Enzyme replacement therapy.
What is galactosaemia? (LO1)
- Genetic disorder - inability to metabolise galactose which leads to galactose accumulation.
- Galactose is instead broken down and converted to toxic metabolism.
- If any of the three enzymes involved in the metabolism of galactose to UDP-glucose are deficient/defective, then galactose accumulates.
- The accumulated galactose is reduced to galactitol and oxidised to galactonate, which are both toxic metabolites.
- The only treatment available for galactosaemia is the elimination of lactose and galactose from the diet.
Explain the normal physiological pathway of galactose metabolism. (LO1)
- Galactose is converted to galactose-1-P.
- Galactose-1-P is converted to UDP-glucose.
- UDP-glucose is a substrate for the synthesis of glycogen (glycogenesis).
Describe glucose metabolism. (LO1)
- After absorption from the intestinal tract, much of fructose and galactose are rapidly converted to glucose.
- In the metabolic pathway of glycolysis, glucose is broken down to pyruvate. This pathway provides 2 ATP molecules and 2 NADH molecules. The 2 NADH molecules are equal to 6 ATP but as 2 ATP molecules have been used, the net ATP production is 4 molecules.
- Glucose can be synthesised from pyruvate in the metabolic pathway of gluconeogenesis.
- In anaerobic glycolysis, pyruvate is reduced to lactate so that glycolysis can continue.
- Pyruvate is further broken down to acetyl-CoA, providing 2 NADH molecules which are equal to 6 ATP molecules.
- Acetyl-CoA is completely oxidised to carbon dioxide in the Krebs cycle. This process provides 2 GTP molecules, 6 NADH molecules which are equal to 18 ATP molecules and 2 FADH molecules, which are equal to 4 ATP molecules.
- In the pentose phosphate pathway, glucose is used to produce NADPH and ribulose-5-P.
- Ribulose-5-P can be converted to ribose-5-P which is a precursor for RNA and DNA.
- Finally, glucose can be stored in the form of glycogen.
How does the 2D diagram of the chemical formulae of carbohydrates indicate the 3D structure of the molecule? (LO1)
- Carbon atoms are numbers by having the lowest number assigned to the carbon atom attached to the functional group (aldehyde/ketone). The rest are numbered consecutively down the chain.
- The backbone of carbon atoms are shown to all lie along the same plane.
- Solid, black wedges coming off the backbone indicate that atoms or groups are located above the plane of the carbon backbone.
- Dotted wedges coming off the backbone indicate that atoms or groups are located below the plane of the carbon backbone.
Compare the structures of these monosaccharides: glucose, galactose, mannose and fructose. (LO1)
- All of these monosaccharides have the same chemical formula of C₆H₁₂O₆ so they are isomers of each other.
- The difference between glucose and fructose is obvious. It’s not so obvious between glucose, galactose and mannose.
- Comparing the structures of glucose and galactose: the hydroxyl group on carbon atom 4 have different orientations - galactose and glucose are C-4 epimers.
- Comparing the structures of glucose and mannose: the hydroxyl group on carbon atom 2 have different orientations - mannose and glucose are C-2 epimers.
Describe what happens with a deficiency of carbohydrate degradation. (LO1)
- This is a hereditary deficiency of individual disaccharides.
- Lactose intolerance (70-80%) of the world’s population is lactose intolerant.
- Isomaltose/sucrose intolerance (10% of Greenland Inuits, 2% of North Americans of the trait).
What are the symptoms of carbohydate degradation deficiency? (LO1)
- Undigested carbohydrates pass into large intestines leading to osmotic diarrhoea.
- Bacterial fermentation of carb products produces large volumes of CO₂ and H₂ in the intestines leading to abdominal cramps, diarrhoea and flatulence.
What is the transtheoretical model? List the stages of this model (6). (LO2)
- Pre-contemplation.
- Contemplation.
- Preparation/determination.
- Action.
- Maintenance.
- Termination.
Describe what occurs in the pre-contemplation stage (1) of the transtheoretical model. (LO2)
- People don’t intend to take action in the foreseeable future.
- Underestimation of pros and emphasis of cons of changing behaviour.
Describe what occurs in the contemplation stage (2) of the transtheoretical model. (LO2)
- People intending to start healthy behaviour in the foreseeable future.
- Pros and cons of changing behaviour is contemplated.
Describe what occurs in the preparation/determination stage (3) of the transtheoretical model. (LO2)
- Ready to take action within 30 days.
- People begin to take small steps towards behaviours and believe changing behaviour will lead to a healthier life.
Describe what occurs in the action stage (4) of the transtheoretical model. (LO2)
- People have recently changed their behaviour and intend to keep moving forward.
- People exhibit modification of problem behaviour and adopting new healthy behaviours.
Describe what occurs in the maintenance stage (5) of the transtheoretical model. (LO2)
- People have sustained the behaviour change for a while and intend to maintain the behaviour.
- They work to prevent relapse of earlier stages.
Describe what occurs in the termination stage (6) of the transtheoretical model. (LO2)
- People have no desire to return to their unhealthy behaviours so no relapse.
- This is rarely achieved and people tend to stay in the maintenance stage.
- This stage is often not even considered in health promotion programmes.
List the processes of change (10). (LO2)
- Consciousness raising: increasing awareness about healthy behaviour.
- Dramatic relief: emotional arousal about health behaviour, whether positive or negative.
- Self re-evaluation: self-reappraisal to realise healthy behaviour is part of what they want.
- Environmental re-evaluation: social reappraisal to realise how their unhealthy behaviour affects others.
- Social liberation: environmental opportunities that exist to show society is supportive of healthy behaviour.
- Self-liberation: commitment to change behaviour based on the belief that achievement of the healthy behaviour is possible.
- Helping relationships: finding supportive relationships that encourage desired change.
- Counter-conditioning: substituting healthy behaviours and thoughts for unhealthy behaviours and thoughts.
- Reinforcement management: rewarding the positive behaviour and reducing rewards coming from negative behaviour.
- Stimulus control: re-engineering the environment to have reminders and cues that support healthy behaviour and remove those supporting unhealthy behaviour.
These processes result in strategies to maintain change.
What is the theory of planned behaviour? List the constructs of this theory (6). (LO2)
- Attitudes.
- Behavioural intention.
- Subjective norms.
- Social norms.
- Perceived power.
- Perceived behavioural control.
Describe the attitude construct (1) of the theory of planned behaviour. (LO2)
- The degree to which a person has an favourable/unfavourable evaluation of a behaviour.
- Consideration of the outcomes of performing the behaviour.
Describe the behavioural intention construct (2) of the theory of planned behaviour. (LO2)
- Motivational factors that influence a given behaviour.
- The stronger the intention to perform the behaviour, the more likely it will be performed.
Describe the subjective norms construct (3) of the theory of planned behaviour. (LO2)
- Refers to the beliefs about whether most people approve or not of the behaviour.
- Relates to the person’s beliefs about whether peers and people of importance think they should engage in the behaviour.
Describe the social norms construct (4) of the theory of planned behaviour. (LO2)
These are considered normative or standard.
Describe the perceived power construct (5) of the theory of planned behaviour. (LO2)
- Perceived presence of factors that facilitate or impede the performance of the behaviour.
- Person’s perceived behavioural control over each of those factors.
Describe the perceived behavioural control construct (6) of the theory of planned behaviour. (LO2)
The level of ease or difficulty of performing the behaviour.
What is the health belief model? List the constructs of this model (6). (LO2)
This is a social psychological health behaviour change model developed to explain and predict health-related behaviours particularly in regard to the uptake of health services. There are 6 constructs to this model:
- Perceived susceptibility.
- Perceived severity.
- Perceived benefits.
- Perceived barriers.
- Cue to action.
- Self-efficacy.
Describe the perceived susceptibility construct (1) of the health belief model. (LO2)
- Person’s subjective view of risk of acquiring illness or disease.
- Wide variations in a person’s feelings of personal vulnerability.
Describe the perceived severity construct (2) of the health belief model. (LO2)
- Person’s feelings on the seriousness of illness or disease.
- Consideration of medical and social consequences.
Describe the perceived benefits construct (3) of the health belief model. (LO2)
- Person’s perception of effectiveness of various actions available to reduce the threat of illness.
- Person would accept the recommended health action if it was perceived as beneficial.
Describe the perceived barriers construct (4) of the health belief model. (LO2)
- Person’s feelings on the obstacles to performing a recommended health action.
- Wide variations in a person’s feelings of barriers which lead to cost/benefit analysis.
- Weighs effectiveness with custom dangers, unpleasantness, time and inconvenience.
Describe the cue to action construct (5) of the health belief model. (LO2)
- A stimulus is needed to trigger the decision-making process to accept a recommended health action.
- Cues can be internal or external.
Describe the self-efficacy construct (6) of the health belief model. (LO2)
The level of a person’s confidence in their ability to successfully perform a behaviour.
What is the COM-B model? (LO2)
This model proposes that there are three components to any behaviour (B).
1. Capability (C).
2. Opportunity (O).
3. Motivation (M).
As each of these components interact, interventions must target one or more of these in order to deliver and maintain effective behaviour change.
Describe the capability component of the COM-B model. (LO2)
Attributes of a person that, together with opportunity, makes a behaviour possible or facilitates it. There are two types of capability:
- Physical capability: capability that involves a person’s physique and musculoskeletal functioning.
- Psychological capability: involves a person’s mental functioning.
Describe the opportunity component of the COM-B model. (LO2)
Attributes of an environmental system that, together with capability, makes a behaviour possible or facilitates it. There are two types of opportunity:
- Physical opportunity: involves inanimate parts of the environmental system and time.
- Social opportunity: involves other people and organisations.
Describe the motivation component of the COM-B model. (LO2)
Aggregates of mental processes that energise and direct behaviour. There are two types of motivation:
- Reflective motivation: involves conscious thought process.
- Automatic motivation: involves habitual, instinctive, drive-related and affective processes.
Describe the interactions between the three components of the COM-B model. (LO2)
- Behaviour influences all three components.
- All three components influence behaviour.
- Capability and motivation influence each other.
- Opportunity influences capability and motivation.
Define compliance with regard to treatment. (LO3)
- The extent to which someone complies with advice provided by a doctor.
- Compliance is a passive behaviour in which the patient is following a list of instructions.
- Doctor-centred approach.
Define adherence with regard to treatment. (LO3)
- The extent to which an individual adheres to agreed advice.
- Adherence is a more proactive behaviour which results in a lifestyle change by the patient, who must follow a daily regimen.
- Suggesting less of a doctor-centred view.
Define concordance with regard to treatment. (LO3)
- Outcomes of a process whereby a doctor and patient come to a mutually agreeable route of action.
- Much more patient-centred.
What counts as medical advice? (LO3)
Asking a patient to:
- Change behaviours.
- Complete physiotherapy exercises.
- Take medications.
How can we assess adherence behaviours? (LO3)
- Pill counts.
- Self-report.
- Clinical outcomes.
How can health professionals improve adherence? (LO3)
- Adherence could be intentional or unintentional.
- Good communication between the patient and doctor doubles adherence.
- Medical adherence has been associated with: socio-economic status, healthcare system, condition therapy and patient-related factors.
List the three factors affecting adherence. (LO3)
- Information.
- Motivation.
- Strategy.
What is meant by information when talking about factors affecting adherence? (LO3)
- Sometimes patients don’t understand what they need to do, maybe due to cognitive capacity, bad communication or an aspect of the illness.
- To reduce this being an issue, test the patient’s understanding.
What is meant by motivation when talking about factors affecting adherence? (LO3)
- Lack of motivation to follow advice stems from health benefits, treatment suggestions, coping strategies, comorbidities and mental well-being.
- Cultural, peer and family beliefs are often taken into account by patients.
- Patients are less likely to stay motivated if they think they can’t successfully achieve it.
- To avoid this, boost their motivation.
What is meant by strategy when talking about factors affecting adherence? (LO3)
- The treatment plan can’t always be just practical.
- Low income and high cost of drugs means they’re difficult to afford.
- This is the same issue with complicated drug regimens.
List the socio-economic factors affecting adherence to medical advice (6). (LO3)
- Family support.
- Other carer factors.
- Social support.
- Stigma.
- Costs of treatment.
- Prescription coverage.
- Socio-economic status.
- Employment status.
List the factors affecting adherence that could be related to the healthcare system (6). (LO3)
- Barriers to healthcare, e.g. language.
- Drug supply.
- Prescription by specialist.
- Information about drug administration.
- Patient-health professional communication and relationship.
- Follow-ups.