Week 8 Chapter 5 Mood Disorders (Caff) Flashcards

a brief overview of Chapter 5 Mood Disorders

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1
Q

Mood Disorders involve disabling disturbances in emotion, from extreme sadness & disengagement of depression to extreme elation & irritability found in mania.
How many broad types of mood disorder are there and what are they?

A

There are 2 broad types of Mood Disorder:

  • Depressive Disorder
  • BiPolar Disorder
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2
Q

What are the main types of depressive disorders?

A

Depressive Disorders include:

  • Major Depression
  • Dysthymia
  • Mixed anxiety/depressive disorder
  • Premenstrual dysphoric disorder
  • Disruptive mood dysregulation disorder
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3
Q

What symptoms might someone with depression experience?

A

They may:

  • become focused on their flaws & deficits
  • view things in a negative light & lose hope
  • Fatigue, low energy & physical aches & pains may develop
  • it may be hard to fall asleep & may wake up frequently
  • Food may taste bland: may lose weight or increase in weight
  • Sexual appetite may disappear
  • Psychomotor retardation or agitation may develop
  • Social withdrawal is common
  • neglecting their appearance
  • thoughts about suicide are common
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4
Q

What’s the proposed DSM-5 Criteria for Major Depressive Disorder?

A
  • Sad mood or loss of pleasure in usual activities
  • At least 5 symptoms (including the above)
  • sleeping too much or too little
  • Psychomotor retardation or agitation
  • Weight loss or change in appetite
  • loss of energy
  • feelings of worthlessness or excessive guilt
  • Difficulty concentrating, thinking, making decisions
  • recurrent thoughts of death or suicide

Symptoms are present nearly every day, most of the day, for at least 2 weeks

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5
Q

Why is Major Depressive Disorder called an episodic disorder?

A

Because symptoms tend to be present for a period of time and then clear

  • even though episodes tend to dissipate over time, an untreated episode can last 5 months or more
  • for a small No. of people the depression becomes chronic
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6
Q

Major Depressive Disorder tends to recur. What often happens?

A

Once a given episode clears, a person is likely to experience another episode.

  • This happens for about two-thirds of people
  • With every new episode a person experiences, their risk for another episode increases by 16%
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7
Q

The DSM-5 will combine Chronic MDD with dysthymia, placing the emphasis on the chronicity of the symptoms. What is the proposed DSM-5 Criteria for Chronic Depressive Disorder (Dysthymia)?

A

Depressed mood for most of the day more than half of the time for 2 years (1 year for children/ adolescents)
At least 2 of the following:
*poor appetite or overeating
*sleeping too much or too little
*Poor self-esteem
*Low energy
*Trouble concentrating or making decisions
*Feelings of hopelessness
The symptoms do not clear for more than 2 months at a time

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8
Q

What are the prevalence rates for MDD and Dysthymia?

A

*MDD is one of the most prevalent psychiatric disorders
*16.2% meet criteria for MDD in their lifetime
*2.5% for dysthymia, which is rarer
*MDD is twice as common in women than men
**MDD is 3 x more common in people with low SES
*MDD is low in Taiwan (1.5%) and highest in Beirut (19%)
*Median onset is now late teens to early 20’s
NB: The resiliency of people who are able to migrate could be a protective factor

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9
Q

What issues are often comorbid with MDD?

A
  • About 60% of people with MDD will also meet criteria for Anxiety disorder
  • Depression is linked to Cardiovascular disease
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10
Q

Why is it inappropriate to consider Dysthymia a milder form of depression than MDD?

A

The chronicity of Dysthymia takes it’s toll
*People with dysthymia are more likely to require hospitalisation, to attempt suicide, and to be impaired in their functioning than people with MDD

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11
Q

What is the proposed DSM-5 Criteria for Premenstrual Dysphoric DIsorder?

A

Symptoms begin after ovulation & end shortly after menstruation begins. On average, the symptoms last 6 days
Emotional symptoms are generally present, and in PMDD, mood symptoms are dominant.
Substantial disruption to personal relationships is typical for women with PMDD.Anxiety, anger, and depression may also occur. The main symptoms, which can be disabling, include:
*Feelings of sadness or despair, or even thoughts of suicide
*Feelings of tension or anxiety
*Panic attacks
*Mood swings or frequent crying
*Lasting irritability or anger that affects other people
*Lack of interest in daily activities and relationships
*Trouble thinking or focusing
*Tiredness or low energy
*Food cravings or binge eating
*Trouble sleeping
*Feeling out of control
Physical symptoms, such as bloating, breast tenderness, headaches, and joint or muscle pain
The symptoms occur during the week before menstruation, and go away once it starts. A diagnosis of PMDD requires the presence of at least five of these symptoms

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12
Q

What is the proposed DSM-5 Criteria for Disruptive Mood Dysregulation DIsorder (DMDD)?

A

DMDD symptoms go beyond describing temperamental children to those with a severe
impairment that requires clinical attention. Far beyond temper tantrums, DMDD is
characterized by severe and recurrent temper outbursts that are grossly out of
proportion in intensity or duration to the situation. These occur, on average, 3 or
more times each week for 1 year or more.

*Children with DMDD display a persistently irritable or angry mood, most of the day and nearly every day, that is observable by parents, teachers, or peers.

A diagnosis requires the above symptoms to be present in at least two settings (at
home, at school, or with peers) for 12 or more months, and symptoms must be severe
in at least one of these settings. During this period, the child must not have gone three
or more consecutive months without symptoms.

The onset of symptoms must be before age 10, and a DMDD diagnosis should not be made for the first time before age 6 or after age 18.

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13
Q

What are the main types of BiPolar disorder?

A

BiPolar Disorders include:
*BiPolar I Disorder
defined by mania

*BiPolar II Disorder
defined by hypomania & episodes of depression

*Cyclothymia

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14
Q

Define Mania & specify how it is differnt from Hypomania

A

Mania is a state of intense elation or irritability. *During a manic episode, people will act & think in ways that are highly unusual to their typical selves

  • they may engage in disastrous behaviours: imprudent sexual activities, overspending, reckless drinking
  • During mania people may become sociable to the point of intrusiveness

Whereas, hypomania, is less extreme - and involves a change in functioning that does not cause serious problems. The person with hypomania may feel more social, flirtatious, energised, & produced

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15
Q

What is the DSM-5 Diagnostic criteria for Manic & Hypomanic Episodes?

A

*Distinctly elevated or irritable mood for most of the day nearly every day.
*Abnormally increased activity and energy
*At least 3 of the following are noticeably changed from baseline (4 if mood is irritable):
-increase in goal directed activity or psychomotor agitation
-unusual talkativeness, rapid speech
-flight of ideas or subjective impression that thoughts are racing
-Decreased need for sleep
-increased self-esteem, belief one has special talents, powers, or abilities
-Distractibility; attention is easily diverted
Excessive involvement in activities that are likely to have undesirable consequences: spending, driving, sexual behaviour

for manic episode:

  • symptoms last 1 week or require hospitalisation
  • symptoms cause significant distress or functional impairment

for hypomanic:

  • symptoms last at least 4 days
  • clear changes in functioning are observable to others but impairment is not marked
  • No psychotic symptoms are present
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16
Q

What is the definition of BiPolar I Disorder?

A

bipolar I disorder includes a single episode of mania during a person’s life

  • Even someone who experiences only 1 week of manic symptoms years ago is still diagnosed with BiPolar I disorder
  • BiPolar I Disorder tends to recur, even more than MDD, with people with BiPolar I Disorder typically experiencing 4 or more episodes
17
Q

What is the definition of BiPolar II Disorder?

A

A person must experience at least one Major Depressive Episode & have at least one episode of hypomania

18
Q

What is the DSM-5 Diagnostic criteria for Cyclothymic Disorder?

A

A. For at least 2 years (1 year in children and adolescents):

  • numerous periods with hypomanic symptoms that do not meet the criteria for a Manic episode
  • numerous periods with depressive symptoms that do not meet criteria for a Major Depressive Episode

B. During the above period, the person has not been without the symptoms in A for more than 2 months in the 2 year period

C. No Major Depressive Episode, Manic Episode, or Mixed Episode has been present during the first 2 years of the disturbance.

D. The symptoms in Criterion A are not better accounted for by Schizoaffective Disorder and are not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified.
E. The symptoms are not due to the direct physiological effects of a substance (e.g. drug of abuse, a medication) or a general medical condition (e.g., hyperthyroidism).

F. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

19
Q

Which of the mood disorders are episodic?

A

*Major Depressive Disorder
*Bipolar I Disorder
*BiPolar II DIsorder
are all episodic
Recurrence is very common in these disorders

20
Q

Which of the mood disorders are characterised by low levels of symptoms that last for at least 2 years?

A
  • Dysthymia

* Cyclothymia

21
Q

Which mood disorder is among the most common psychiatric disorder?

A
  • Major Depression
  • it affects 16.2% of people during their lifetime
  • rates are twice as high for women as men
22
Q

Which mood disorder is among the least common psychiatric disorder?

A
  • Bipolar I Disorder

* affects 1% or less of the population

23
Q

What do genetic studies tell us about the heritability of mood disorders?

A

that BiPolar Disorder is strongly heritable & depression is somewhat heritable

24
Q

By focusing on the sensitivity of receptors rather than on the amount of various receptors, how has neurobiological research added to our understanding of Mood Disorders?

A

Neurobiological research has provided:

  • strong evidence for diminished sensitivity of the serotonin receptors in Depression & Mania
  • some evidence that Mania is related to heightened sensitivity of the dopamine receptors
  • & that Depression is related to diminished sensitivity of the dopamine receptors
25
Q

What neurobiological processes seem to be related to BiPolar & UniPolar disorders?

A
  • Elevated activity of the amygdala & the subgenual anterior
  • Diminished activity in the dorsolateral prefrontal cortex & Hippocampus during tasks that involve emotion & emotional regulation
26
Q

What neurobiological processes seem to be related to episodes of Mania?

A
  • greater levels of activation of the striatum

* possible elevations in the protein kinase C

27
Q

What is overactivity of the HPA (hypothalamic-adrenal axis) associated with and how is it indexed?

A

overactivity of the HPA is:

  • associated with severe forms of Depression and BiPolar Disorder
  • indexed by poor suppression of cortisol by dexamethasone
28
Q

What do socio-environmental models of mood disorders focus on?

A

*the role of negative life events
*lack of social support
*family criticism
as triggers for episodes
*also considered are the ways in which a person with depression may elicit negative responses from others
*people with less social skills & those who tend to seek excessive reassurance are at elevated risk for the development of depression

29
Q

Which personality trait is most related to depression and predicts the onset of depression?

A

Neuroticism

30
Q

What are the main cognitive theories of depression?

A
  • Beck’s cognitive theory
  • Hopelessness theory
  • Rumination Theory
  • all argue that depression can be caused by cognitive factors
  • though they take a different approach to the nature of the cognitive factors that cause depression
  • Cross-sectional & prospective evidence is available for each model
31
Q

What are the main differences between the key cognitive theories of depression?

A

The main theories take a different approach to the nature of the cognitive factors that cause depression

  • Beck’s theory focuses on the cognitive triad, negative schemas, & cognitive biases
  • Hopelessness theory focuses on low self-esteem, or beliefs that a life event may have long-term consequences leading to hopelessness
  • Rumination theory focuses on the negative effects of repetitively dwelling on the reasons for a sad mood
32
Q

What are some of the psychological theories of depression?

A

These are similar for BiPolar & UniPolar Depression

  • Manic symptoms arise because of dysregulation in the reward system of the brain
  • Mania can be triggered by life events involving goal attainment
  • Mania can also be triggered by sleep deprivation
33
Q

What are some of the common treatments for depression?

A

Several psychological therapies are effective for depression:

  • Interpersonal therapy
  • Cognitive therapy
  • Behavioural Activation Therapy
  • Behavioural Couples Therapy
34
Q

What are some of the common treatments for BiPolar Disorder?

A

Several psychological therapies are effective for BiPolar Disorder in addition to medication:

  • Psychoeducation
  • Family Therapy
  • Cognitive Therapy
35
Q

What other treatments have been found to be effective in the treatment of depression & BiPolar Disorder?

A

Depression:
Several anti-depressants: tricyclics, SSRIs, MAOIs
*ECT - for treatment resistant depression

BiPolar Disorder:

  • Lithium (best researched treatment)
  • antipsychotic & anticonvulsant medications decrease mania
  • Antidepressants are considered controversial in the treatment of BiPolar Depression
36
Q

Who is at elevated risk of suicide?

A
  • Men, the elderly & people who are divorced or widowed
  • Most people who commit suicide meet the diagnostic criteria for psychiatric disorders, with more than half having depression
37
Q

What else do we know about suicide?

A
  • Suicide is at least partially heritable
  • Neurobiological models focus on serotonin & overactivity of the HPA
  • Environmental factors e.g. celebrity suicides & economic recession increase suicide rates
  • Social Isolation is a robust predictor of suicide
38
Q

What else do we know about the psychological vulnerability of suicide?

A
  • poor problem solving skills
  • hopelessness
  • lack of a reason to live
  • suicidal action appears related to impulsivity
39
Q

What are some of the suicide prevention approaches that have been tried?

A
  • Psychological treatments and medications for those already experiencing mental health issues
  • CBT can reduce suicidal ideation
  • Phone help-lines