Week 8

Question 1

Quality of final preparation is dependent on

Answer 1

compatibility and stability parameters

Question 2

Define stability

Answer 2

Retention of properties and characteristics throughout the storage and use periods

Question 3

Define instability

Answer 3

Results when a change or degradation of the active ingredient occurs

Question 4

Define expiration date

Answer 4

Assigned by manufacturer

Determined using extensive analytical testing

Question 5

Define BUD

Answer 5

Assigned by pharmacists

Determined based on scientific evidence

Question 6

BUD MDV

Answer 6

28 days from entering

Question 7

BUD SDV in hood

Answer 7

6 hours

Question 8

BUD No hood

Answer 8

1 hr

Question 9

BUD Ready to use

Answer 9

As indicated

Question 10

BUD vial systems

Answer 10

As indicated unless opened

Question 11

Low with 12 hours or less BUD

Answer 11

12 hr room and refrige NO frozen

Question 12

Low BUD

Answer 12

Room: 48 hrs
Refrige: 14 days
Frozen: 45 days

Question 13

Medium BUD

Answer 13

Room: 30 hrs
Refrige: 9 days
Frozen: 45 days

Question 14

High BUD

Answer 14

Room: 24 hrs
Refrige: 3 days
Frozen 45 days

Question 15

Define incompatibility

Answer 15

Undesirable rxn between: two drugs, a drug and an excipient, a drug with container
Chemical rxn between two or more components of a mixture

Question 16

Three type of incompatibilities

Answer 16

Therapeutic
Physical
Chemical

Question 17

Chemical and physical can result in

Answer 17

Influence in therapeutic efficacy of drugs

Question 18

Define Chemical incompatibility

Answer 18

Results from a chemical rxn which affects molecular structure or activity of product

Question 19

Define Physical Incompatibility

Answer 19

Results in changes in the physical properties of the product

Question 20

Evidence of incompatibility

Answer 20

Color change
Precipitate
Phase separation
Bubbles
Heat/cold
Crystals

Question 21

Factors affecting stability and compatibility

Answer 21

pH
Temp
Light
Mixing sequences
Time
Concentration

Question 22

Define Calcium Phosphate

Answer 22

Formed when calcium salts are added to electrolytes containing phosphate
Chemical rxn with physical change

Question 23

PN Risk

Answer 23

Suboptimal delivery of Ca and phosphorous
Occlusion of in-line filter
Microvascular embolism
PE

Question 24

Preventing Incompatibilities

Answer 24

Verify solubilities
Determine chemical form of drug
Determine risk of precipitation
Determine storage and handling conditions

Question 25

Minimize Risk of Incompatibility

Answer 25

Use quickly
Minimize amount of drugs
Utilize references
Closely review in high or low pH
Closes review if Ca, P or Mg is involved

Question 26

Visual Inspection

Answer 26

Always hold preparation up to light to see through

Always check preparation against a contrasting backgroud