Week 8 Flashcards
define: mood disorders
- recurrent disturbances or alterations in mood that cause psychological stress and behavioral impairement
what are two exemplars of mood disorders
- unipolar depression (major depressive episode)
- bipolar disorder
describe the continuum of mood disorders
mania mild to mod depression –> severe depression
how can we distinguish between grief/sadness and a depressive disorderr?
- length of time they have symptoms
- degree of symtpoms
- do they feel hope?
what is the key diagnostic criteria for major depressive disorder (3)
- at least a 2-week history of 5 or more of the symptoms on the upcoming slide
- symptoms represent a change from baseline
- symptoms cause significant distress/impairment in functioning
what symptoms are included in the diagnostic criteria for major depressive disorder (9)
- Depressed mood most of the day, nearly every day**
- Markedly diminished interest/pleasure in activities most of the day, nearly every day**
- Significant weight loss or weight gain/decreased or increased appetite
- Difficulty sleeping (insomnia or hypersomnia) or sleeping day and night
- Psychomotor agitation (physical energy or restlessness) or retardation (slow movement)
- Fatigue/loss of energy
- Feelings of worthlessness or inappropriate guilt despite reassurance from others (cannot get a though out of their head as they are feeling excessively guilty)
- Inability to concentrate or indecisiveness
- Recurrent thoughts of death/suicide (not every pt will have thoughts of sucide but there are elevated risk)
** at least 1 of either depressed mood or loss of interest/pleasure must be present
disorder qualifiers to describe/define depression (8)
- Major Depressive Disorder (MDD)
- Mild, moderate, severe
- Dysthymia
- Seasonal pattern
- Psychotic depression
- Post-partum (onset of sx have to occur within 4 weeks of child birth)
- Co-occurs with medical conditions
- Depression in youth and teens
describe symptoms seen in youth/teen depression (5)
- irritable or angry mood
- “acting out” behaviors
- unexplained aches and pains
- extreme senstivity to criticism
- withdrawing from some, but not all people
untreated depression in youth & teens can lead to (8)
- low self esteem
- problems at school/running away
- substance abuse
- eating disorders
- violence
- self-injury
- suicide (15-19 years of age, 2nd leading cause of death - indigenous youth)
- comorbid diagnosis (with ADD, anxiety)
what are some common complaints seen w depression in older adults (5)
- focus on physical health symptoms
- weight loss
- poor appetite
- anhedonia
- social isolation
what are some less common complaints r/t depression in older adults (2)
- depressed mood/sadness/crying
- weight gain
describe the significance of depression (7)
- WHO cites depression as 3rd in disease burden in the world.
- Statistics Canada indicates approx. 2-6% of the population at any time are depressed
- Lifetime prevalence: any age, present in all demographic groups, 25% women, 12% for men
- Cultural variations
- Escalating incidence and cost to society
- Past frequency of episodes is best predictor of future recurrences.
- Significant suicide risk - 15% die by suicide if not treated.
what factors contribute to depression? (5)(
- biological factors
- cognitive distortions
- psychosocial factors
- early childhood experiences
- combo of factors
describe how biological factors can contribute to depression (3)
- disruption in the balance of neurotransmitters (ex. serotonin, NE, MOA)
- genetic vulnerability
- CNS neurotransmitter abnormalities that result from enviro and medical factors (ex. check thyroid lvl, biochemical factors)
describe how cognitive distortions can contribute to depression (3)
- distorted attitudes
- learned helplessness
- irrational beliefs (irrational thoughts leading to a depressive, negative “world view” –> ex. someone in ur past telling you you’re a failure, not letting it go, and incorporating it into your self talk)
describe how psychosocial factors can contribute to depression (3)
- life events, circumstances
- recent stressors
- perceptions of helplessness, powerlessness
what are some approaches to treatment/care for depression (10)
- pharmacologic (traditional antidepressants, IV Ketamine)
- ECT
- TMS (or rTMS)
- CBT
- psychotherapy
- mindfulness
- psychosocial
- education
- health promotion
- health and wellness
what are examples of antidepressants (7)
- SSRIs (selective serotonin reuptake inhibitors)
- SNRIs (serotonin norepinephrine reuptake inhibitors)
- NRIs (norepinephrine reuptake inhibitors)
- NDRIs (norepinephrine dopamine reuptake inhibitors)
- SNDIs (serotonin-norepinephrine disinhibitors)
- TCAs (tricyclic antidepressants)
- MAOIs (monoamine oxidase inhibitors)
what are examples of SSRIs
- fluoxetine (prozac)
- paroxetine (Paxil)
- Citalopam (Celexa)
describe the use of SSRIs (3)
- safer in overdose
- cardiac toxicity decreased
- common side effects (see p. 259, 261, and 262)
what is an exmaple of a SNRI
- venlafaxine (effexor)
what are examples of atypical antidepressants (3)
- trazodone (Desyrel)
- buproprion (given in low doses, aids w sleep)
- remeron (also aids w sleep)
what is an important consideration w SSRIs
- should not stop meds abruptly –> risk of discontinuation syndrome
what are symptoms of discontinuation syndrome (7)
- flu-like symptoms
- nausea
- electric shock sensations
- headaches
- vertigo –> gait instability
- anxiety/irritability
- insomnia
what should you assess r/t discontinuation syndrome
- VS
- MSE
- lytes
- serum drug lvls
- medication use
what is serotonin syndrome
- symptoms due to excessive amt of serotonin in the system
what are symptoms of serotonin syndrome (7)
- MSE changes (ex. delirium)
- fever
- tachycardia
- HTN
- tremor
- diarrhea
- neuromuscular symptoms
how can serotonin syndrome be treated (3)
- hold dose
- d/c serotonin posting substances
- symptom management `
what do you want to assess w serotonin syndrome (4)
- vitals
- mental status
- med list
- blood work
what are examples of TCAs (2)
- imipramine
- clomipramine
what are some side effects of TCAs
- very dangerous in overdose (cardiotoxicity)
- anticholinergic effects (constipation, urinary retention, dry mouth)
- increased risk of delirium
who are we more concerned w r/t TCAs
- more concerned w older adults due to the other comorbidities going on