week 7- IBS and IBD Flashcards by Wade Quilter

Q

MOA

Lubiprostone (Amitiza)

Class/use

A

Lubiprostone activates chloride channels → secretion of chloride-rich intestinal fluid → increase in intestinal motility → eases passage of stool

IBS-C

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Q

Adverse Effects

Lubiprostone (Amitiza)

A

nausea, abdomnal pain, diarrhea, headache, chest tightness

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Q

MOA

Linaclotide (Linzess)

ClaSS

A

Linaclotide is a guanylate cyclase-c agonist → cGMP → stimulation of chloride secretion→ increase in luminal fluid → accelerated intestinal transit

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Q

Adverse Effects

Linaclotide (Linzess)

A

diarrhea, abdominal pain, headache

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