Week 7 Flashcards
What is the most common cause of cardiac transplantation in america?
- End-stage heart failure
- Cardiomyopathy (48%)
- CAD (44%)
- Congenital
- Valvular defect
- Retransplant
- Other
What are the indications for cardiac transplantation?
- Cardiogenic shock requiring continuous inotropic support or mechanical support
- Persistent NYHA functional class IV symptoms refractory to treatment
- Intractable angina
- Intractable life-threatening arrhythmias
- Congenital heart disease with NYHA III/IV symptoms refractory to treatment
What are the absolute contraindications to a cardiac transplantation?
- Irreversible Pulmonary vascular resistance
- Malignancy
- Active infection
- HIV/AIDS
What are the relative contraindications to a cardiac transplantation?
• Age>65* • Poorly Controlled DM with organ damage/failure • Psychosocial impairment that jeopardizes transplanted heart - Arnold Palmer and VA Example • Cigarette smoking • Unreliable Caregivers
What are the characteristics of the donor allocation system?
• Supervised by United Network of Organ Sharing (UNOS)
- Private organization designed to ensure equitable distribution of organs
• Organ Procurement and Transplantation Network (OPTN)
• Divided into 11 regions
• Prioritization based on
- Severity of illness
- Geographic Distance from Donor
- Patient time on wait list
What are the characteristics of a Status 1A patient on the (UNOS)?
• Reside in transplant listing center AND
- On mechanical ventilation
- On IABP, TAH or ECMO
- Hemodynamic monitoring with IV ionotropes
• 30 days after LVAD and/or RVAD
- Total artificial heart discharged from listing center (for 30 days post-discharge)
- LVAD with device-related complication
What are the characteristics of a Status 1B patient on the (UNOS)?
- IV ionotropes or implanted chronic mechanical assist device
- TAH after discharge
What are the characteristics of a Status 2 patient on the (UNOS)?
Patient who don’t meet 1A or 1B requirements
What are the procedures done for a cardiac transplantation?
- Median sternotomy
* Cardiopulmonary bypass
What are the characteristics of a Status 7 patient on the (UNOS)?
Patients who are temporarily unsuitable for transplant
What are the characteristics of a ex- vivo heart perfusion?
Used to help keep the heart pumping and viable before being put in a body
What are the biopsy monitoring guidelines to follow after cardiac transplantation?
- Every week for the first 4 weeks
- Every 2 weeks for the following 6 weeks
- Monthly for the next 3-4 months
- Every 3 months until the end of the first year
- 3-4 times per year in the second year
- One to two times per years following
What are the physiological changes seen post transplant?
• Transplanted heart is denervated
• Higher resting HR (90-110bpm)
• Absence of direct neural regulation of HR/SV
- HR and SV controlled via circulating catecholamines and muscle pump
• Absence of chest pain
What is the exercise capacity of a patient post heart transplant?
- 56% of patient exercise capacity is <70% of predicted normal
- Only 13% achieve >90% predicted normal
What are the contributing factors to exercise capacity of a patient post heart transplant?
• Transition from type 1 to type 2 fibers
- Especially for patients with previous long standing HF
• Neuro-hormonal changes from long standing HF resulting in elevated TPR
• Side effects of corticosteroids and immunosuppressive therapy
What is the peak time a person gets to live after a heart transplant?
10 years. Unless they got it at a younger age
What kills most patients after a heart transplant?
- Graft failure (within 1st 30 days)
- Infection (within the 1st year)
- Malignancy and graft failure (within 1st 5 years)
How many METs of exercise does a patient get after a heart transplant?
Up to 6-7 METs
What are the indications for a lung transplant?
- Emphysema/COPD: Bronchiectasis, A-1-A deficiency
- Cystic Fibrosis (younger population)
- Pulmonary Fibrosis
- Pulmonary Hypertension
- Retransplant (often in cystic fibrosis)
- Congenital
- Sarcoidosis, RA, Inhalation burns/trauma
What are the contraindications for a lung transplant?
- Uncontrolled infection
- Malignancy (within past 2 yrs)
- Significant dysfunction of other organs
- Significant chest wall/spinal deformity
- Active smoking, drug, alcohol dependency
- HIV
- Ongoing hepatitis B or C
- Unresolved psychosocial/absence of support system
What are the guidelines for a lung transplant?
- Appropriate age (generally <65)
- Clinically and physiologically severe disease
- Ineffective medical therapy
- Limited life expectancy due to lung disease
- Acceptable nutritional status (80-120% of ideal body weight)
- Satisfactory psychosocial profile and support
- Adequate financial coverage
What are the characteristics of the UNOS: Lung Allocation Score (LAS)?
• The lung allocation score (LAS) is used to prioritize waiting list candidates based
on a combination of waitlist urgency and post-transplant survival.
• Expected # days lived without
• Expected # days lived during first year post-transplant
What are the factors in the UNOS: Lung Allocation Score (LAS)?
- FVC
- Pulmonary Artery Pressure
- Oxygenation Status
- Age
- BMI
- Diabetes
- Functional Status
- 6MWD (typically 150ft)
- Ventilation Status
- PCWP
- Serum Creatitine
- PCO2
- Diagnosis
- Bilirubin
What are the procedures used for a lung transplant?
• Single lung transplant (thoracotomy)
- Also see this procedure used for resection and lobectomy
• Double lung transplant (clamshell)
• Lobar transplant from living donor
What kills most patients after a lung transplant?
- Graft failure (within 1st 30 days)
- Infection (within the 1st year)
What is the exercise capacity of a patient post lung transplant?
• Peak exercise capacity following lung transplantation typically improves to
40-60% of the predicted level.
- Despite satisfactory graft lung function
• 2years post transplantation.
- Average 6MWD improvements following transplantation range between
307ft-498ft
Chronic disease prior to transplant leads to…?
- Muscle weakness
- Prolonged hospitalization
- Fatigue
- Prolonged bedrest or confinement to home
- Decreased mobility
- Poor breathing mechanics
- Inability to clear pulmonary secretions
What are the pre-transplant rehab goals?
• Preserve muscle strength and endurance • Maximize functional independence • Education - What to expect post-transplant - Precautions? - Getting them used to wearing masks • Pre-transplant has been shown to have beneficial effects on post-transplant mortality, functional capacity and quality of life • Most increases are seen within the 1st couple of week, and deteriorates
What are the post transplant rehab guidelines in the Inpatient Phase (1-2 weeks)?
- Early Mobility in ICU
* Gait, balance, ADLs, Functional Mobility etc
What are the potential barriers of post transplant rehab in the Inpatient Phase (1-2 weeks)?
- Acuity of illness
- Medical/cognitive
- Ventilation/sedation
- Line placement
- Lab values and vital signs outside of safe ranges
- Inpatient testing and procedures
- Patient compliance
What are the inpatient goals for post transplant rehab?
• Increase functional capacity
• Improve level of independence
• Progression of exercise
• Education
- HEP
- Guidelines for termination of exercise
- Special considerations for exercies post-transplant
What are the post transplant rehab guidelines in the outpatient Phase (2-12 weeks)?
• Outpatient Phase (2-12 weeks)
- First 10 weeks: VO2 improvement approx. 1 MET from baseline
- 6 months to 1 year: 2 MET from baseline
- Exercise Capacity improvements typically plateau within first 1yr
• UE resistive training for cardiac and lung transplant patients should be delayed until 6
weeks post transplant when wound and tissue healing is complete
- Delayed wound healing due to medications
What are some rehabilitation considerations post organ transplant?
• Motivation and adherence to exercise are the major problems
• Studies have found that patients who have participated in exercise interventions
following transplantation have scored higher on quality of life questionnaires 1 year
and 5 years post transplant in addition to demonstrating increased exercise capacity
(measured by VO2 peak)
- HEP performed regularly may also help reduce side effects of immunosuppressant medications
What are some rehab considerations with heart transplants?
• Sternal precautions
• Denervation of heart
- Warm-up, cool down
- RPE scale to monitor
exercise intensity
• HR is higher at rest
• Risk of myopathy, osteoporosis
• Typically no anginal symptoms due to denervation
• May see 2 p-waves on ECG
• Peak HR is reduced and may remain elevated post exercise
• Peak oxygen consumption (VO2 peak) is reduced
• Systolic and diastolic BP may be elevated at rest, but peak exercise systolic pressure is
usually lower.
• Reduced sensitivity of ECG to detect ischemia
What are some rehab considerations with lung transplants?
• Quad muscle biopsies after lung transplant show reduced skeletal muscle oxidative capacity
• RPE and dyspnea- preferred methods of monitoring intensity
• Musculoskeletal complaints, post-surgical chest wall pain and osteoporosiscommon post-transplant complications
• Myopathy involving respiratory and peripheral muscles- may be related to meds
• “Bronchial hyperresponsiveness” after transplant may contribute to
bronchospasms and SOB during exercise
What is Cardiac rehabilitation (rehab)?
A medically supervised program that helps improve the health and well-being of people who have cardiovascular disease and conditions
What do cardiac rehab programs include?
Exercise training, education on heart healthy living, and
counseling to reduce stress and help you return to an active life
What are the components of cardiac rehab?
• Exercise training • Physical activity counseling • Tobacco cessation • Nutritional counseling • Weight management • Lipid management • Blood pressure management • Diabetes management • Psychosocial Counseling (Stress) • Sexual counseling • Alcohol Consumption Counseling
What are the diagnoses that are eligible for cardiac rehab?
• Acute myocardial infarction
• Stable angina
• Coronary artery bypass graft surgery
• Heart valve repair or replacement
• Percutaneous transluminal coronary angioplasty
• Heart transplantation or heart-lung transplantation
• HEART FAILURE!!!!!
- Stable class II and class III heart failure patients without complex arrhythmias
What are the contraindications for cardiac rehab?
- Unstable angina,
- Decompensated heart failure,
- Complex ventricular arrhythmias,
- Pulmonary arterial hypertension greater than 60 mmhg,
- Intracavitary thrombus,
- Recent thrombophlebitis with or without pulmonary embolism,
- Severe obstructive cardiomyopaties,
- Severe or symptomatic aortic stenosis,
- Uncontrolled inflammatory or infectious pathologies and
- Any musculo-skeletal condition that prohibits physical exercise
What are the benefits of cardiac rehab?
• Risk reduction in mortality of 20% or higher, sustained up to 5yrs post
• Reduced recurrent MI by 17%, 47% mortality benefit at 2 years
• HFrEF CR demonstrate significant reductions (15%) in all-cause and cardiovascular
mortality and heart failure hospitalization.
• Decreased re-hospitalizations
• Increased rate of return to work from 38% to 53%
• 12-weeks participation in cardiac rehabilitation has demonstrated reduces
medical costs by 739$ per patient
- After only 21 months follow-up
- Possibly more cost effective than medications!
• A study in Sweden showed that participation in cardiac rehab resulted in an overall cost savings of $12,000 per patient
What are the risks of cardiac rehab?
• Overall, cardiac rehabilitation is safe and well tolerated with a very low rate of major
complications such as death, cardiac arrest, myocardial infarction or serious injuries.
• 1 event in 60,000-80,000 patient-hours of supervised exercise.
• Patients most at risk are those with residual ischemia, complex ventricular arrhythmia and severe left ventricular dysfunction (ejection fraction of less than 35%), especially NYHA III or IV
What are the modifiable risk factors for heart disease?
- Smoking
- DM
- HTN
- ApoB/A1
What is the participation in cardiac rehab like?
- Only 14% to 35% of heart attack survivors
* Only 31% of patients after CABG participate
What are the barriers to participation of cardiac rehab?
- Limited Financial resources
- Transportation difficulties
- Lack of social or emotional support
- Limited to no physician endorsement/support
- Lower Education level
- Cultural beliefs and understanding of disease and treatment
- Program availability and characteristics
- Older individuals are less likely to be referred to and to participate in cardiac rehabilitation
What are some ways to address barriers to participation of cardiac rehab?
- Including referral to CR/SPP in the hospital discharge plan
- Automatically referring all eligible patients at the time of hospital discharge
- Group Classes (Social Group)
- Use of TeleHealth
- Patient selection of setting