Week 5 Flashcards
What are the indications for pulmonary pharmacological interventions?
• Reduce bronchospasm • Reduce inflammation/allergic reaction • Reduce mucous production • Treat bacterial infection • Improve Oxygenation • Special Considerations: - Cough suppressant - Smoking cessation
What role does the sympathetic nervous system play in pulmonary?
Causes bronchodilation by increase cAMP, resulting in:
• Facilitates smooth muscle relaxation
• Inhibition of Mast Cells (inflammatory response and mucous production)
What role does the parasympathetic nervous system play in pulmonary?
Causes bronchocontrstriction by increasing cGMP resulting in:
• Facilitates smooth muscle constriction
• Facilitation of Mast Cells (inflammatory response and mucous production)
What is the primary method of drug administration to the lungs?
Primarily through inhalation (aerosol)
• May also be delivered orally or IV
What are the benefits of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
- Rapid delivery and absorption of medication
- Large Surface area
- Delivered Directly to tissue
- Less systemic effects
What are the limitations of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
- Unable to predict exact dosage
- Delivery is dependent on inspiratory flow
- Can be irritating to tissues
How is an inhaler used properly?
• Shake for 2-5 seconds, remove cap, inspect inhaler
• If the inhaler hasn’t been used in a while, may need to prime it.
• Breathe out all the way.
• Start breathing in slowly through your mouth, then press down on the inhaler 1
time.
• Keep breathing in slowly, as deeply as you can.
• Hold breath and slowly count to 10.
• Wait about 1 minute before you take your next puff (Beta agonists only)
What is a spacer?
Also known as aerosol-holding
chambers, add-on devices and
spacing devices, long tubes that slow the delivery of medication from pressurized MDIs.
What are the characteristics of a spacer?
• Helps improve delivery of
medication.
• Often used for inhaled
corticosteroids and with younger patients
What is a nebulizer?
A device that mix drugs with air to form a fine mist that is inhaled through a mask
What are the characteristics of a nebulizer?
• Prolongs the delivery of the medication (10minutes)
• Originally thought to improve delivery of medication to distal bronchioles (Inconclusive)
• Useful for patients who cannot perform MDI technique correctly
- Young children
- Patients in acute distress
What are the general classifications of bronchodilators for pulmonary pharmacology?
- (SNS) Adernergic Agonists (Sympathomimmetics)
- (PNS) Cholinergic antagonists (Anti-cholinergic)
- Methylxanthines
What are the characteristics of bronchodilator: Epinephrine (Epi-Pen)?
- Non specific beta agonist
- Used most often in emergent cases (anaphylaxis and sepsis/resp failure)
- Can be delivered (IV, IM, SubCut or Inhalation)
- Short time to effect 3-15minutes
- Short peak effect time ~20minutes
- Will affect other tissues with beta and alpha receptors
What are the characteristics of Bronchodilator Adernergic Agonist: SABA-Short acting (rescue)?
- Albuterol (Ventolin) (most common)
- Time to effect 5-15min
- Duration: 3-6hrs
What are the characteristics of Bronchodilator Adernergic Agonist: LABA-Long acting (maintenance)?
Salmeterol (Serevent)
• Time to effect: 10-20minutes
• Duration: 12hrs
What are the side effects for Bronchodilator Adernergic Agonist?
- Tachycardia,
- Tremors
- Nervousness,
- Restlessness
- Weight Loss
What does Bronchodilators: Cholinergic antagonists do?
Block the muscarine receptors in the bronchioles (LAMA)
What are the characteristics of Bronchodilators: Cholinergic antagonists?
• Drug of choice for COPD • Not used as often for asthma • Not absorbed well into bloodvstream • Less side effects than Beta Agnonists • Most Common: - Ipratropium (Atrovent) 3 4/day - Tiotropium (Spiriva) 1/day
What medicine provides a mix between SABA and LAMA?
Combivent
• Ipratropium bromide and
albuterol sulfate.
What are the characteristics of Bronchodilators: Methylxanthines?
Aka Xanthine deriviatives
• Common examples:
- Theophylline, Theobromine and caffeine
• Inhibit phosodiesterase enzyme
(PDE).
- Increases cAMP
- May also act as an adenosine antagonist
• Most common delivery route is oral, may also be injected (IV)
What are the side effects of Bronchodilators: Methylxanthines?
- Tachycardia, HA, irritability, restlessness
* Theophylline Toxicity: can cause arrthymias and seizures
What is the mechanisms of action of anti-inflammatory: glucocorticoids?
- Control inflammatory mediated bronchospasm
- Inhibit production of pro-inflammatory products (cytokines, prostaglandins, leukotrienes etc)
- Decreases vascular permeability
- Immunosuppression: Inhibits migration of neutrophils and monocytes
- Increases the effect of Beta Agonsits
What are the characteristics of inhaled anti-inflammatory: glucocorticoids?
Used often for long term maintenance of Asthma
• Budenoside (Pulmicort), Beclemethasone (Belcovent), Fluticasone (Flovent)
What are the characteristics of oral anti-inflammatory: glucocorticoids?
Used often with acute infections, or exacerbations, 1-3weeks max
• Prednisone
What are the characteristics of IV anti-inflammatory: glucocorticoids?
Use in severe asthma attacks (status asthmaticus) or respiratory distress
• Methylprendisolone (Medrol)
What are the side effects of anti-inflammatory: glucocorticoids?
Hyperglycemia, HTN, Osteoporosis, Myopathy, Mood Swings.
• Less side effects with Inhaled Delivery
What is the suffix for anti-inflammatory: glucocorticoids?
- Sone
What do leukotrienes cause?
- Airway hyperresponsiveness
- Inflammation
- Smooth muscle hypertrophy
- Mucous secretion
- Heavily involved in asthma
What are the characteristics of leukotriene inhibitors?
• Montelukast (Singulair) • Inhibits the effects of leukotrienes - Airway hyperresponsiveness - Inflammation - Smooth muscle hypertrophy - Mucous Secretion • Great for Asthma, “OK” for COPD • Delivered in pill form • Enhance effects of glucocorticoids and allows for smaller dosages. - Often prescribed together
What are the characteristics of pulmonary fibrosis medications?
• Pirfenidone (Esbriet) and nintedanib (Ofev)
• Anti-Fibrotic medication
• Inhibit pathways that lead to fibrosis and scaring of lungs
- Suppress fibroblast proliferation, reduces fibrogenic mediator production,
• Prior to these medications there were no true IPF meds
- Oxygen and Steroids (not ideal)
What is histamine?
A endogenous chemical involved in regulating modulating several physiological functions:
• CNS neural modulation, gastric secretions and hypersensitivity reactions
• 4 receptor subtypes (H1-H4)
• H1 are involved with the respiratory system and
hypersensitivity
- Nasal Congestion, sinusisitis, rhinitis, mucousal
irritation,
What are effects of antihistamines?
Block these receptors, most are non specific
What are the side effects of antihistamines?
Sedation, fatigue, dizziness,
incoordination
What is the most common form antihistamine?
Diphenhydramine (Benadryl)
What is the function of nasal decongestants?
Relieve nasal congestion in the upper respiratory tract
What is the most common nasal decongestants?
Alpha-1 agonist
What are the characteristics of nasal decongestants?
Pseudoephedrine (Sudafed) • Causes vasoconstriction in nasal passages • Essentially “dries up” muscousal vasculature and reduces nasal congestion • Oral or Nasal Spray
What are the functions of mucolytics?
- Decrease viscosity (thickness) of respiratory secretions
* Allows for easier mobilization of secretions up the “muco-cilliary elevator”
How are mucolytics delivered?
Often delivered orally • Guanefisine (Mucinex) • Guanefisine and antitussive (Robitussin) - dextromethorphan (DM) - Codeine (DAC)
What are the functions of antitussive?
Suppress coughing response/ reflex
• Due to irritation in airways and sinuses
What are the characteristics of antitussive not always being indicated?
• Makes it difficult to get rid of the mucus that
collects in the lungs and airways.
• May increase secretions
• Asthma and young children
What are the general types of antitussive?
• Central mediated inhibition: codeine and dextromethorphan (DM)
- Opiates, Act on brainstem
• Local mediated inhibitors: Antihistamines and local anesthetics
- Act on respiratory tissue
What are the functions of antibiotics?
• Treatment of acute exacerbation or infection
- Increased dyspnea, Increased chest congestion AND FEV1 < 50%.
• Treatment of acute bronchitis or pneumonia
• Prevention of acute exacerbation (prophylactic antibiotics)
What are the most common forms of antibiotics?
• Bactericidal
- Penicillins: Penicillin and Amoxicillin,
- Cephalosporins: Ciprofloxacin (Cipro)
• Bacterostatic:
- Macrolides: Azithromycin (Zpack)
What are the characteristics of influenza vaccines?
• Reduce serious illness and mortality in patients with COPD
• GOLD and CDC recommends annual vaccine for:
- Patients with COPD
- Patients with pulmonary fibrosis
- Patients with asthma >6months of age
- The elderly, ages >50years of age
- Young Children, ages 6months-4years of age
- Health-care personnel
- Morbidly Obese patients BMI>40
- Immunosuppressed patients
What are the indications for oxygen therapy?
- Hypoxemia
- Reduce work of breathing
- Reduce work of the heart (especially RV)
What type of patients is oxygen therapy typically for?
For patients with Pulse Oximetry <88% or SpO2 <55mmHg
• May also be prescribed for patients with PAH and RV HF
• Patients with chronic COPD may have different guidelines
What is the general pulse oximetry goal for patients on oxygen therapy during exercise?
Above 90%
____ is the main risk factor in the development of COPD
Smoking is the main risk factor in the development of COPD
What are the benefits of smoking cessation?
- Improves Respiratory symptoms
- Reduces Bronchial hyperresponsiveness
- Prevents accelerated decline in lung function and may improve FEV1.
- In all smokers
How fast does lung function improve when someone stopped smoking?
Within a week
What predicts the difficulty of smoking cessation?
- How much one smokes on a daily basis
* Within 30 minutes of waking up each day.
What are medications usually prescribed to help with during smoking cessation?
- Help reduce the craving for tobacco; Bupropion (Zyban)
- Help reduce withdrawal symptoms; Varenicline (Chantix).
- Nicotine replacement therapy: most helpful for people who smoke >.75PPD
How do we assess respiratory muscle strength?
By measuring Maximum Inspiratory (MIP & Expiratory Pressure (MEP)
How do we assess Chest Wall Mobility?
Posture, Chest wall excursion, Rib and Thoracic Spine
Mobility
How do we assess Respiration?
Arterial Blood Gases (ABG), Pulse Oximetry (SpO2)
How do we assess Ventilation?
Spirometry (FVC and FEV1), Respiratory Rate (RR),
How do we assess Lung Segment Examination?
Fremitus, Voice Sounds, Breath Sounds
How do we assess Cough function?
Independence, Sputum Assessment
How do we assess Quality of Life and Subjective Report?
VAS, RPE, MMRC Dyspnea Scale, St George’s Respiratory Scale, Dyspnea Index
How do we assess Exercise Capacity?
6MWT, Max Test, Submax
How do we assess Balance?
BERG, POMA, DGI, BEST
How do we assess Mobility?
5 or 10m Gait Speed, TUG,
How do we assess Strength?
5Ttime Sit to Stand, 30 Sec Sit to stand
What are we taking note of in the visual inspection aspect of observation?
- Disposition: Distress, Short of breath, Somnolent etc
* Skin: Edema, JVD, Cyanosis, Sweating
What are we taking note of in the body position/posture aspect of observation?
Normal, Barrel Chest, slouched, guarding, pes escavatum or Pectus carinatum
What are we taking note of in the breathing pattern aspect of observation?
• Rate and Depth
- Neck, Chest, Abdomen
• Accessory muscle usage
• Asymmetrical Paradoxical Chest Wall Movements
• Nasal Flaring
• Pulse Oximetry RA or with supplementation
What are the instructions on how to get into the tracheal position?
• Have the patient flex neck slightly
• Place your index finger in the suprasternal notch
• Place the top of finger in suprasternal notch medial to left SC joint.
• Push inwards toward the cervical spine
• Repeat on right side
• Normal test
- No obstruction to the advancement of the finger.
• Most Common Cause of deviation: Midline shift due to Pneuomothorax (moves away from lesion)
When is thoracic wall palpation indicated?
If there is chest pain, a mass seen on inspection, breast masses, or draining sinuses.
What are you palpating for during thoracic wall palpation?
• Examine for tenderness and masses
- Soft tissues (also assess for crepitus
- Large thoracic muscles
- Costal cartilages, intercostal spaces, costochondral junctions and xiphisternal
• Palpate the ribs for point tenderness, swelling, crepitus, and pain on chest compression.
How is the compression test for rib fracture done?
With one hand supporting the back, compression of the sternum with the other elicits pain at the untouched fracture site.
How do we test for thoracic wall movement symmetry?
• Place a hand on each side of the chest wall
• Extend thumbs so their tips meet in the midline.
• Have the patient inspire deeply permitting your palms to move freely with the chest while your fingers are anchored on the chest wall.
• Normally, the thumbs move laterally from midline in equal distances.
• Asymmetric excursions suggest a lesion on the lagging side in the chest wall,
the pleura, or the upper lobe of the lung.
What is the hand placement when palpating the upper thorax for thoracic wall movement symmetry?
Trapezius
What is the hand placement when palpating the mid thorax for thoracic wall movement symmetry?
Axilla
What is the hand placement when palpating the posterior thorax for thoracic wall movement symmetry?
Latissimus Dorsi
What is the hand placement when palpating the Costal Margins for thoracic wall movement symmetry?
Lateral Ribs
How do we test for thoracic wall movement excursion?
Place measuring tape around chest wall
• Xiphoid process is Most reliable landmark
• May also use Axilla and interval between
xiphoid and umbilicus
• Normal excursion is 2-3inches or 4-6cm
How do we test for tactile fremitus?
• Increased transmission of sound, can be detected as fremitus over the affected area
while the patient repeatedly vocalizes
- “one, two, three” or “99”
• The examiner moves his or her palms systematically over the two hemithoraces.
• Common Causes of increased fremitus (Vibration)
- Consolidation of the lung
• Conversely, impairment of sound transmission, as by a pleural effusion, diminishes
vocal fremitus.
• A good test to start chest exam
- Not very specific however due to size of hands
- If differences are appreciated always follow up with auscultation
What are the characteristics of mediating percussion?
Evaluates regional or side-to-side differences in lung density
• Normal lung density willsound resonant (table)
• Areas of increased density (e.g. consolidation, atelectasis) will sound dull. (quads)
• Areas of decreased density (e.g. emphysema) will sound hyperresonant. (puffed out cheeks or bloated belly)
What are the instructions of mediating percussion?
• Place pad of middle finger of non dominant hand on the subject’s chest in the intercostal space.
• Using the middle finger of your dominant hand, tap the knuckle of the middle finger of
your non dominant hand .
- Keep Percussing finger rigid, tap like woodpecker
• Listen for the pitch of the sound produced and note the vibrations from the chest with your finger
What are the presentations of purulent sputum?
- Inflammatory cells, enter the airways and alveoli in response to lower airway infection.
- May be yellow, green, or dirty gray.
In what conditions is purulent sputum in small amounts produced?
Acute bronchitis, resolving pneumonia, small tuberculous cavities, or lung abscess
In what conditions is purulent sputum in copious amounts produced?
Bacterial Pneumonia, Lung abscess, bronchiectasis, or bronchopleural fistula communicating with an
empyema.
In what conditions is purulent sputum in foul smelling amounts produced?
Anaerobic infection (PNA) and/or lung abscess.
What are the characteristics of stringy mucoid sputum?
Increased mucous production and mucous plugs occur in asthma; during resolution retained mucous and mucous plugs are mobilized.
What are the characteristics of bloody sputum “hemoptysis”?
- Coughing up blood or bloody mucous
* Hallmark sign of Pulmonary Embolism, may also occur with trauma, pneumonia
What are the characteristics of Blood-Streaked Sputum?
- inflammation in the nose, nasopharynx, gums, larynx, or bronchi.
- Sometimes it occurs after severe paroxysms of coughing and minor airway trauma
What are the characteristics of Frothy Pink Sputum?
- Alveoli and respiratory bronchioles are flooded with fluid from the capillaries
- Producing thin secretions containing air bubbles, frequently colored with hemoglobin.
- Hallmark sign of pulmonary edema
What are the characteristics of the evaluation of diaphragmatic action?
- Patient lays supine with anterior chest exposed
- Palpate anterior chest well with thumbs over costal margins so tips meet at xiphoid
- Instruct patient to sniff of take deep breath, allow thumbs to move with chest wall
- Normal test is equal upward movement of the costal margins
• ***Can also be done in sitting using percussion and markings pre and post
inspiration,
• Normal should see ascent to T10 expiration, descent to T12 inspiration
How is the maximum inspiratory effort conducted?
My having the subject expire
to a residual volume (RV) (ie, fully expire) and then perform a maximum inspiratory maneuver.
• Opposite for Expiratory Pressures