Week 6 – Alzheimer’s Disease Genetics and Toxicity

Question 1

In early onset inherited AD how many mutations have been identified in PS1?

Question 2

In early onset inherited AD how many mutations have been identified in APP?

Question 3

Some of these mutations can increase the concentration of Ab monomer, but not all, why do these cause early onset AD?

Question 4

What is the connection between Down’s syndrome and Alzheimer’s disease?

Question 5

Describe the different interactions between Ab assemblies and lipid membranes.

Question 6

Name three nano-scale imaging techniques used to investigate amyloid interactions with lipid bilayers.

Question 7

Amyloid beta can form ion channels across the membrane, only one form of Ab can do this- which is it?

Question 8

An approximate diameter of a channel can be calculated using patch-clamping - how is this done? And what diameter is indicated?

Question 9

In what way does the cellular-prion protein affect Ab fibril formation?

Question 10

How does the Alzheimer’s therapy, described in 2016, work?