Week 5 – Alzheimer’s Disease Fibril Assemblies Flashcards
What five proteins make up gamma secretase complex?
Which protein is key at the active site of the gamma secretase complex??
PS1
Name the four different hydrophobic amino acid types in the C-terminus of Ab?
Describe the three phases to a nucleation polymerisation reaction.
Explain five microscopic kinetic rate constants that describe fibril growth curves.
Ab forms fibrils rapidly at pH 5.3, why is this?
The x-ray diffraction pattern of fibrils indicates two key repeating structural features of the cross-beta architecture, what are they?
The basic topology of Ab40 and Ab42 fibrils are different. What key stabilizing interaction has changed?
Fibril structures can be highly poly-morphism, if the basic topology of the structure is unchanged what interaction make the structure-morphologies different?
What is the evidence for strains in AD?
