Week 6 Flashcards
1
Q
Why is it difficult to detect if GH supplements have been taken?
A
- Can not distinguish between exogenous (from external source) or endogenous (made in the body)
- GH has a pulsatile increase (therefore, peaks unexpectedly)
- Due to genetics, GH levels can he higher
- Has a short half life of only 20 minutes
2
Q
What does Exogenous and Endogenous mean?
A
Exogenous: from an external origin (man made)
Endogenous: from internal origin (body)
3
Q
What is Ghrelin?
A
Ghrelin: the orexigenic hormone or hunger hormone
- Increases gastric secretion and motility
- Acts at arcuate nucleus of hypothalamus to increase appetite
4
Q
What is the effect of Ghrelin on GH?
A
- Ghrelin is secretagogue for GH
- Increases GH secretion
- In response to low FFA and AA, the GH increases to stimulate the brake down on glycogen and fats
5
Q
Does dopamine or cortisol increase growth hormone?
A
Dopamine: increases GH
Cortisol: decreases GH
6
Q
What hormones are necessary for foetal development:
A
- IGF-2
- IGF-1
- Insulin
- Fibroblast growth factor
- Placental growth factor
- Epidymal growth factor
7
Q
Does love IGF-1 always mean a GH deficiency?
A
No:
IGF-1 Levels can decrease due to:
- Chronic disease
- Poor nutrition
- Hypothyroidism
8
Q
What does hypothyroidism do to IGF-1 Levels?
A
Decreases them
