Week 5 Heart Failure (HF) Flashcards
what is HF?
an abnormal condition involving impaired cardiac pumping
HF (aka ___) is not a ____ but a “___”
CHF
disease
syndrome
HF is associated with what 2 chronic disorders?
long-standing HTN & CAD
How does HF results?
Results from the heart’s inability to pump amt of oxygenated blood needed to meet metabolic requirements of body
What are the 2 US statistics regarding HF?
- Affects >5 million people
2. Most common reason for hospitalization in adults older than 65
About how many people in the United States have heart failure?
5.7 million people
One in ___ in 2009 included heart failure as contributing cause.
9 deaths
About ___ of people who develop heart failure die within __ years of diagnosis.
half
5
Heart failure costs the nation an estimated ___ each year. This total includes the cost of ___, ___ heart failure, and ____.
$30 billion
health care services
medications to treat
missed days of work
Which part of the US has the highest death rates of HF from 2011 to 2013?
middle region, near Texas, (“bible belt”)
What are the 5 HF risk factors?
- CAD and its risk factors
- age
- htn
- high cholesterol
- African American descent
How is CAD and its risk factors, risk factors for HF?
smoking, obesity, and sedentary lifestyle
How is age a risk factor of HF?
HF is most common reason for hospitalization of pts greater than 65 y/o.
How is htn a risk factor of HF?
- to compensate for increase bp, the heart muscle thickens.
- over time, the force of heart muscle contraction weakens preventing normal filling of heart with blood.
How is African American descent a risk factor of HF?
- their race is related to the higher incidence of htn and dm.
- have a 30% higher mortality rate.
what is the etiology of HF?
may be caused by an interference with normal mechanisms regulating cardiac output
formula of CO?
CO = HR X SV
amt of blood pumped from LV with each contraction
CO is influenced by what 5 things?
- Preload: volume of blood in ventricle at end of diastole
- afterload: force ventricle must develop to eject blood into circulatory system
- myocardial contractility
- heart rate
- metabolic state of individual.
Pathophysiology of Systolic Heart Failure: (5)
- Most common cause of CHF: MI - Heart wall weakens from extra workload
- “Squeeze” of ventricles is issue
- LV loses ability to generate enough pressure to eject blood forward
- -Difficulty emptying
- -The hallmark is a ↓ LV ejection fraction - Ejection fraction of 50 – 75% is considered normal
- With L side failure it usually falls below 40%
Pathophysiology of Diastolic Heart Failure: (5)
- Impaired ability of ventricles to fill during diastole: Commonly caused by HTN
- Inability to fill & relax LV is issue
- Usually result of LV hypertrophy
- Pulmonary congestion
- Normal ejection fraction
One compensatory mechanism of HF is?
Compensatory mechanisms are activated to maintain adequate CO
How does our bodies maintain adequate CO? what changes? (3)
- Sympathetic nervous system (SNS) activation
- Neurohormonal responses: Low CO causes a decrease in cerebral perfusion pressure
–Antidiuretic hormone (ADH) is secreted and causes increased water reabsorption in the renal tubules leading to water retention and increased blood volume - Neurohormonal responses: Kidneys release renin
–Renin converts angiotensinogen to angiotensin I
Angiotensin I is converted to angiotensin II by a converting enzyme made in the lungs
What is one consequence of compensatory mechanism?
Ventricular dilation: Enlargement of the chambers of the heart that occurs when pressure in the left ventricle is elevated
- -Initially an adaptive mechanism
- -Eventually this mechanism becomes inadequate and CO decreases
- -Ventricular Hypertrophy: Increase in the muscle mass and cardiac wall thickness in response to chronic dilation; heart muscle
- -Ventricular Remodeling
What is another consequence of compensatory mechanism?
it is known as the Counter-regulatory processes
- Natriuretic Peptides (hormones):
- –Released in response to increases in atrial volume and ventricular pressure
- -Promote venous and arterial vasodilation, reducing preload and afterload
- Atrial natriuretic peptide (ANP) = ↑ diuresis
- Brain natriuretic peptide (BNP) (secreted by ventricles) – a measure of the “stretch” of heart tissues