Week 5 - Cell signaling - Drewes Flashcards
How is NO biosynthesized in the body?
Breakdown of Arginine to citrulline.
Also taking nitroglycerine will give you some NO.
NO can then activate cGMP which promotes vasodilation.
Big simplified difference between GPCR’s and tyrosine kinases?
GPCR’s act mostly through 2nd messengers
Tyrosine kinases act through kinases
IOnotropic vs Metabotropic effectors:
Ionotropic are fast-acting with immediate response!
Metabotropic recptors are much slower and involve more downstream junk
Know the function of the ryanodine receptor and its association with malignant hyperthermia.
Ryanodine receptors mediate the release of calcium ions from the endoplasmic reticulum
Use Ca++ or IP3 to stimulate Ca release! Woo! Positive feedback!
If it gets too crazy without stopping then you can get malignant hyperthermia, which is bad. This comes about de to a mutation in the recptor along with anesthesia use. Too much ATP is being hydrolyzed and creates heat.
