Week 5: Antianginal Drugs

Question 1

What is ventricular wall stress?

Answer 1

Force on fibers tending to pull them apart - we spend energy to oppose this

Question 2

Contributors to ventricular wall stress?

Answer 2

= (P x r)/2h
P: assoc with pre and afterload
h: vent wall thickness

Question 3

MOA: NO with angina

Answer 3

activates guanylyl cyclase -> GMP to cGMP -> dephosphorylation of myosin LC -> relaxation

Question 4

Longer duration nitrates? Uses?

Answer 4

Isosorbide dinitrate or mononitrate. Oral prophylaxis

Question 5

Nifedipine MOA and TU

Answer 5

Dihydropyridine. HTN, prophylaxis of angina.

Question 6

What drug class reduces mortality of patients with recent MI?

Answer 6

Beta blockers.

Question 7

What long term positive effects do beta blockers have?

Answer 7

Decrease mortality and prevent stroke in patients with hypertension.

Question 8

What is the advantage of combination Nitrates + Beta or Ca Blocker

Answer 8

Mitigate each other’s negative effects for net positive effect.