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Pharmacogenomics > week 5 > Flashcards

week 5 Flashcards

1
Q

pharmacodynamics

A

Study of effects of drugs on body, receptor binding, post receptor effects and chemical interactions

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2
Q

target proteins pharmacodynamics act on

A

Receptors
ion cahnnels
carrier molcules
enzymes

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3
Q

Agonist

A

bind to receptor and activates receptor to produce biological response

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4
Q

Antagonist

A

dampens biological response by binding to receptor and blocking

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5
Q

example of enzyme inhibitor

A

Simvastatin

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6
Q

example of inhibits proton pump in gastric mucosa

A

Omeprazole

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7
Q

B blockers-

A

used to treat CV disease- HF, hypertension

Block signaling through B adroreceptors

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8
Q

B adrenoreceptor involved in cardiac rate

A

ADBR1 is one involved in cardiac rate

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9
Q

Malignant hyperthermia

A

Autsomal dominant disorder of skeletal muscle

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10
Q

gene causing malignant hyperthermia

A

50-70% cases due to RYR1 gene variation- ryanodine receptor

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11
Q

mechanism causing malignant hyperthermia

A

Calcium release normall casuign muscle contraction is released continually due to RYR receptor sensitisation on SR need for cellular energy needed during contraction- heat is produced- dramatically increased during episode of MH

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12
Q

Triggering agents for malignant hyperthermia

A

suxamethonium or volatile anesthetic agents- calcium floods into cell due to mutations in RYR1

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13
Q

effect of RYR1 mutation

A

Mg is not bound as tightly and can depolarize membrane at a much lower level

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14
Q

previous testing for MH

A

muscle biopsy, in vitro contractor test- halothane and caffeine exposed- normal relaxes when exposed to halothane but MH will contract and can be measured Mh is more sensitive to caffeince so cotnracts at lower concs

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15
Q

What are statins used for

A

Lipid lowering drug

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16
Q

examples of statins

A

Simvastatin

atorvastatin

17
Q

Pharmacodynamic mutation effecting statins and effect

A

Dynmaic- HmGCR- enzyme

changes in gene for HMGCoA reductase- target of statins- 2 variants in non codin regions- decreased response

18
Q

pharmacoKinetic variation effecting statins and effect

A

SLC01B1 OATP1B1- sodium independent organic anion transporter involved in cellular influex of statins into hepatocytes reduced transport into hepatocytes so increased systemic conc leading to muscle degredation and kidney damage

Pharmacogenomics (11 decks)

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