week 4 - LTD

Question 1

Outline Kasai et al 2003 on glutamate sensivity and volume of dedritic spine head

Answer 1

Looked at post synaptic dendritic spine structure and expression of AMPA receptors

Compared a glutamate sensitivity map with images of spine structure/volume

The maximum glutamate sensitivity is significantly correlated with volume of dendritic spine head

Question 2

Where are AMPA receptors located

Answer 2

In the central postsynaptic density

Question 3

What is the structure of AMPA receptors, and how can they be manipulated

Answer 3

They have four different subunits which can be alternatively spliced and RNA edited to form tetrameric ion channels

Question 4

What is evidence that AMPA receptors are the primary conduits of excitatory synaptic transmission

Answer 4

Look at Lisman et al 2007 paper

Look at sheperd and huganir (2007)

Question 5

What study should i read to show that bidirectional synaptic plasticity encodes memory

Answer 5

collingridge et al 2010

Question 6

What study should i read to know about reduction of neuronal activity - the function of certain types of learning

Answer 6

lee et al (2006)