WEEK 4 - LEUKOCYTES: GRANULOCYTIC & AGRANDULOCYTUC SERIES Flashcards by Jamella Vivienne | Brainscape

Q

CMP

A

Common Myeloid Progenitor

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Q

CLP

A

Common Lymphoid Progenitor

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Q

The earliest morphologically identifiable granulocytic precursor

A

Myeloblast

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Q

SIZE: 14-20um (Myeloid)

A

Myeloblast

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Q

Cytoplasm: (Myeloid)
Usually in moderate blue in color

A

Myeloblast

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Q

Cytoplasm: (Myeloid)
Texture is smooth and usually non-granular

A

Myeloblast

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Q

Nucleus: (Myeloid)
Round ir slightly oval

A

Myeloblast

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Q

(Myeloid)
- Nucleus: Occupies about 4/5 of the cell
- N:C ratio: 4:1

A

Myeloblast

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Q

Nucleus: (Myeloid)
Extremely fine chromatin pattern

A

Myeloblast

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Q

Nucleus: (Myeloid)
Reddish Purple

A

Myeloblast

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Q

Nucleus: (Myeloid)
2-5 nucleoli

A

Myeloblast

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Q

SIZE:(Myeloid)
16-25 um (Normally slightly larger than the its precursor)

A

Promyelocyte

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Q

Cytoplasm: (Myeloid)

Pale blue to basophilic

A

Promyelocyte

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Q

Cytoplasm:(Myeloid)
Contains a few to many, large blue reddish-purple staining primary azurophilic/nonspecific
granules

A

Promyelocyte

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Q

(Myeloid)
- Nucleus: Occupies half or more of the cell
- N:C ratio is 3:1 to 2:1

A

Promyelocyte

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Q

NUCLEUS: (Myeloid)
oval or round

A

Promyelocyte

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Q

Nucleus: (Myeloid)
Chromatin pattern may become a little coarser

A

Promyelocyte

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Q

Nucleus: (Myeloid)
2-3 nucleoli present

A

Promyelocyte

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Q

SIZE: 14-16um (Myeloid)

A

Myelocyte

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Q

Cytoplasm:
Moderate amount (Myeloid)

A

Myelocyte

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Q

Cytoplasm: May contain a few patches of blue (Myeloid)

A

Myelocyte

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Q

Cytoplasm: Few to moderate nonspecific granules (Myeloid)

A

Myelocyte

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Q

Cytoplasm: Small, specific granules begin to appear
(Myeloid)

A

Myelocyte

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Q

Nucleus:
Oval or round
(Myeloid)

A

Myelocyte

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Q

(Myeloid)
- Nucleus may be centrally located
- N/C ratio is 1:1

A

Myelocyte

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Q

Nucleus: Chromatin pattern becomes coarser and more
condensed
(Myeloid)

A

Myelocyte

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Q

Nucleus: no nucleoli
(Myeloid)

A

Myelocyte

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Q

SIZE: 10-15um (Myeloid)

A

Metamyelocyte

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Q

Cytoplasm:
Moderate to abundant amount giving a
decrease N/C ratio (Myeloid)

A

Metamyelocyte

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Q

Cytoplasm: Few non-specific granules, Full complement of
specific granules (Myeloid)

A

Metamyelocyte

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Q

Nucleus: Indented or kidney shaped (Myeloid)

A

Metamyelocyte

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Q

Nucleus: Coarse chromatin pattern and stains dark purple
(Myeloid)

A

Metamyelocyte

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Q

SIZE: 9-15um (Myeloid)

A

Band/Stab

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Q

Elongated band shaped deeply indented compared
to metamyelocyte (Myeloid)

A

Band/Stab

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Q

Coarse and clumped chromatin pattern (Myeloid)

A

Band/Stab

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Q

SIZE: 9-15um (Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Cytoplasm
: Full complement to pink to rose-violet specific
granules (Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Cytoplasm
: Full complement to pink to rose-violet specific
granules (Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Cytoplasm: Abundant amount
(Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Cytoplasm: Few non-specific granules are present (Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Nucleus:
Normally 2-5 lobes connected by thin nuclear filaments (Myeloid)

A

NEUTROPHILS/ POLYMORPHONUCLEAR CELL

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Q

Neutrophil - Primary (______) Granules

A

Azurophilic

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Q

Neutrophil - Secondary (________) Granules

A

Specific

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Q

Neutrophil - _________ Granules

A

Tertiary

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Q

SIZE: 9-15um (Myeloid)

A

Eosinophil

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Q

Cytoplasm:
Contains full complement if large reddish-orange granules (Myeloid)

A

Eosinophil

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Q

Nucleus:
Normally 2 lobes (Myeloid)

A

Eosinophil

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Q

EOSINOPHIL GRANULES: formed during promyelocyte stage that contains Charcot-Leyden crystal protein

A

Primary Granules

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Q

EOSINOPHIL GRANULES: formed throughout remaining maturation

A

Secondary Granules

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Q

EOSINOPHIL GRANULES: Carry proteins from secondary granules to be released into the extracurricular medium

A

Storage vesicles

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Q

SIZE: 10-16um (Myeloid)

A

Basophil

Q

Cytoplasm:
Stains slightly pink to colorless
(Myeloid)

A

Basophil

Q

Cytoplasm: Contains specific dark purple to Blue-black
granules (Myeloid)

A

Basophil

Q

Cytoplasm: Granules are water soluble and tend to wash
out when stained (Myeloid)

A

Basophil

Q

Nucleus:
Does not appear as coarse as that of
neutrophils and eosinophils (Myeloid)

A

Basophil

Q

Nucleus: Generally segmented or bilobed, rarely 3-4
lobes
(Myeloid)

A

Basophil

Q

Basophil Specific Granules

A

Histamine, Heparin, Peroxidase, Eosinophilic
Chemotactic factor A

Q

Nucleus is rounded and the cell is packed with large basophilic granules (Myeloid)

A

Mast cells

Q

Size: 12 to 25um (tend to be a little larger than basophils) (Myeloid)

A

Mast Cells

Q

SIZE: 12-20um (MONOPOIESIS)

A

Monoblast

Q

Cytoplasm: (MONOPOIESIS)
- Moderately basophilic to blue-gray
- Non-granular

A

Monoblast

Q

Nucleus: (MONOPOIESIS)
- Ovoid or round in shape
- N/C ration is 4:1 in color

A

Monoblast

Q

Nucleus: Fine, Lacey chromatin (MONOPOIESIS)

A

Monoblast

Q

Nucleus: 1-2 nucleoli (MONOPOIESIS)

A

Monoblast

Q

SIZE: 12-18um (MONOPOIESIS)

A

Promonocyte

Q

Cytoplasm: (MONOPOIESIS)
- Blue-gray
- May contain fine dust like
- Azurophilic granules

A

Promonocyte

Q

Nucleus: (MONOPOIESIS)
- Oval, may have single fold or fissure
- N/C ratio is 3:1 – 2:1

A

Promonocyte

Q

Nucleus: (MONOPOIESIS)
- 1-5 nucleoli
- Fine chromatin pattern

A

Promonocyte

Q

SIZE: 15-20um (MONOPOIESIS)

A

Monocyte

Q

Cytoplasm:
Abundant, blue-gray (MONOPOIESIS)

A

Monocyte

Q

Cytoplasm: Outline may be irregular because of the
presence of pseudopods (MONOPOIESIS)

A

Monocyte

Q

Cytoplasm: Many fine azurophilic granules, giving ground
glass appearance (MONOPOIESIS)

A

Monocyte

Q

Cytoplasm: Vacuoles may sometimes be present (MONOPOIESIS)

A

Monocyte

Q

SIZE: 40-50um (MONOPOIESIS)

A

Macrophages

Q

have an oval nucleus with at least one
rather prominent nucleolus and netlike (reticulated)
chromatin pattern (MONOPOIESIS)

A

Macrophages

Q

cytoplasm is pale, frequently vacuolated, and
often filled with debris of phagocytized cell or
organisms (MONOPOIESIS)

A

Macrophages

Q

SIZE: 10-18um (Lymphopoiesis)

A

Lymphoblast

Q

Cytoplasm: (Lymphopoiesis)
- No granules present
- Appears smooth

A

Lymphoblast

Q

Cytoplasm: (Lymphopoiesis)

Moderate to dark blue
May stain deep blue at the periphery and light
blue near the nucleus

A

Lymphoblast

Q

Cytoplasm: More abundant than in myeloblast (Lymphoblast)

A

Lymphoblast

Q

Nucleus (Lymphopoiesis)
- Round or oval in shape
- N/C ratio is 4:1

A

Lymphoblast

Q

Nucleus: Chromatin pattern is somewhat coarse (Lymphopoiesis)

A

Lymphoblast

Q

Nucleus: 1-2 nucleoli (Lymphopoiesis)

A

Lymphoblast

Q

May be the same size as the precursor (Lymphopoiesis)

A

Prolymphocyte

Q

Cytoplasm: (Lymphopoiesis)
- Moderate to dark blue

A

Prolymphocyte

Q

Cytoplasm: (Lymphopoiesis) Usually, non-granular but may contain
occasional azurophilic granules

A

Prolymphocyte

Q

Cytoplasm: More abundant than in Lymphoblast (Lymphopoiesis)

A

Prolymphocyte

Q

Nucleus: (Lymphopoiesis)
- Round, oval and slightly indented

A

Prolymphocyte

Q

Nucleus: (Lymphopoiesis)
Chromatin pattern is more clumped than in the
lymphoblast

A

Prolymphocyte

Q

Nucleus: (Lymphopoiesis)
May contain 1-2 nucleoli

clue. PRO

A

Prolymphocyte

Q

Cytoplasm: (Lymphopoiesis)
- Usually forms thin rim around the nucleus

A

Small Lymphocyte

Q

Cytoplasm: Moderate to dark blue (Lymphopoiesis)

A

Small Lymphocyte

Q

Nucleus: (Lymphopoiesis)
- Round, oval and slightly indented

A

Small Lymphocyte

Q

Nucleus: Chromatin pattern is dense and clumped
(Lymphopoiesis)

A

Small Lymphocyte

Q

Nucleus: No nucleoli visible (Lymphopoiesis)

A

Small Lymphocyte

Q

Cytoplasm: (Lymphopoiesis)
- More abundant than in small lymphocyte

A

Medium Lymphocyte

Q

Cytoplasm:
Pale to moderate blue (Lymphopoiesis)

A

Medium Lymphocyte

Q

Cytoplasm: May or may not contain a few non-specific
azurophilic granules (Lymphopoiesis)

A

Medium Lymphocyte

Q

Cytoplasm: (Lymphopoiesis)
- Abundant
- Clear, very pale blue

A

Large Lymphocyte

Q

Cytoplasm: May or may not contain a few nonspecific
azurophilic granules
(Lymphopoiesis)

A

Large Lymphocyte

Q

Cytoplasm: Robin’s Egg blue cytoplasm (Lymphopoiesis)

A

Large Lymphocyte

Q

Nucleus: May be eccentrically located (Lymphopoiesis)

A

Large Lymphocyte

Q

Nucleus: Chromatin pattern is dense and clumped (Lymphopoiesis)

A

Small Lymphocyte, Medium Lymphocyte

Q

Nucleus: Chromatin pattern is coarse (Lymphopoiesis)

A

Large Lymphocyte

Q

Nucleus: No nucleoli visible (Lymphopoiesis)

A

Small Lymphocyte, Medium Lymphocyte, Large Lymphocyte

Q

Nucleus: Round, oval in shape and may be slightly
indented (Lymphopoiesis)

A

Small Lymphocyte, Medium Lymphocyte, Large Lymphocyte

Q

10-20% Lymphocytes

A

B Lymphocytes

Q

Differentiates into plasma cells that secretes immunoglobulins

A

B Lymphocytes

Q

Humoral Immunity

A

B Lymphocytes

Q

Derived from the Bone Marrow

A

B Lymphocytes

Q

60-80% Lymphocytes

A

T Lymphocytes

Q

Mature in the thymus (near the heart in the chest
cavity)

A

T Lymphocytes

Q

Interact with antigens to form specific effector
cells which act in delayed hypersensitivity
reactions, suppression of tumors, graft rejections

A

T Lymphocytes

Q

Cellular Immunity

A

T Lymphocytes

Q

Lymphocytes that make antibodies

A

B Lymphocytes

Q

Lymphocytes that helps to kill tumor cells and help control immune responses

A

T Lymphocytes

Q

Less than 10% Lymphocytes

A

NATURAL KILLER CELLS / NULL LYMPHOCYTES

Q

Destruction of tumors and virus infected cells
without antigen specificity or prior sensitization

A

NATURAL KILLER CELLS / NULL LYMPHOCYTES

Q

morphologically resemble large granular lymphocyte (LGL)

A

NATURAL KILLER CELLS / NULL LYMPHOCYTES

Q

Function as PHAGOCYTES

A

Neutrophil, Eosinophil, Basophil, Monocyte

but most common is the Neutrophil

Q

Function as IMMUNOCYTES

A

Lymphocytes

Q

known as A-GRANULOCYTES

A

Monocyte and Lymphocyte

Q

known to be the FIRST DEFENDER when there’s a bacterium (foreign bodies)

A

Lymphocyte

Q

LARGEST WBC can be seen in Peripheral Blood Smear

A

Monocyte

Q

MOST ABUNDANT WBC

A

Neutrophil

Q

LEAST ABUNDANT WBC

A

Basophil

Q

When it develops in the tissues it is known as
MACROPHAGES

A

Monocyte