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HEMATOLOGY > WEEK 4 - LEUKOCYTES: GRANULOCYTIC & AGRANDULOCYTUC SERIES > Flashcards

WEEK 4 - LEUKOCYTES: GRANULOCYTIC & AGRANDULOCYTUC SERIES Flashcards

1
Q

CMP

A

Common Myeloid Progenitor

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2
Q

CLP

A

Common Lymphoid Progenitor

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3
Q

The earliest morphologically identifiable granulocytic precursor

A

Myeloblast

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4
Q

SIZE: 14-20um (Myeloid)

A

Myeloblast

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5
Q

Cytoplasm: (Myeloid)
Usually in moderate blue in color

A

Myeloblast

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6
Q

Cytoplasm: (Myeloid)
Texture is smooth and usually non-granular

A

Myeloblast

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7
Q

Nucleus: (Myeloid)
Round ir slightly oval

A

Myeloblast

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8
Q

(Myeloid)
- Nucleus: Occupies about 4/5 of the cell
- N:C ratio: 4:1

A

Myeloblast

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9
Q

Nucleus: (Myeloid)
Extremely fine chromatin pattern

A

Myeloblast

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10
Q

Nucleus: (Myeloid)
Reddish Purple

A

Myeloblast

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11
Q

Nucleus: (Myeloid)
2-5 nucleoli

A

Myeloblast

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12
Q

SIZE:(Myeloid)
16-25 um (Normally slightly larger than the its precursor)

A

Promyelocyte

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13
Q

Cytoplasm: (Myeloid)

Pale blue to basophilic

A

Promyelocyte

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14
Q

Cytoplasm:(Myeloid)
Contains a few to many, large blue reddish-purple staining primary azurophilic/nonspecific
granules

A

Promyelocyte

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15
Q

(Myeloid)
- Nucleus: Occupies half or more of the cell
- N:C ratio is 3:1 to 2:1

A

Promyelocyte

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16
Q

NUCLEUS: (Myeloid)
oval or round

A

Promyelocyte

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17
Q

Nucleus: (Myeloid)
Chromatin pattern may become a little coarser

A

Promyelocyte

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18
Q

Nucleus: (Myeloid)
2-3 nucleoli present

A

Promyelocyte

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19
Q

SIZE: 14-16um (Myeloid)

A

Myelocyte

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20
Q

Cytoplasm:
Moderate amount (Myeloid)

A

Myelocyte

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21
Q

Cytoplasm: May contain a few patches of blue (Myeloid)

A

Myelocyte

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22
Q

Cytoplasm: Few to moderate nonspecific granules (Myeloid)

A

Myelocyte

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23
Q

Cytoplasm: Small, specific granules begin to appear
(Myeloid)

A

Myelocyte

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24
Q

Nucleus:
Oval or round
(Myeloid)

A

Myelocyte

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25
(Myeloid) - Nucleus may be centrally located - N/C ratio is 1:1
Myelocyte
26
Nucleus: Chromatin pattern becomes coarser and more condensed (Myeloid)
Myelocyte
27
Nucleus: no nucleoli (Myeloid)
Myelocyte
28
SIZE: 10-15um (Myeloid)
Metamyelocyte
29
Cytoplasm: Moderate to abundant amount giving a decrease N/C ratio (Myeloid)
Metamyelocyte
30
Cytoplasm: Few non-specific granules, Full complement of specific granules (Myeloid)
Metamyelocyte
31
Nucleus: Indented or kidney shaped (Myeloid)
Metamyelocyte
32
Nucleus: Coarse chromatin pattern and stains dark purple (Myeloid)
Metamyelocyte
33
SIZE: 9-15um (Myeloid)
Band/Stab
34
Elongated band shaped deeply indented compared to metamyelocyte (Myeloid)
Band/Stab
35
Coarse and clumped chromatin pattern (Myeloid)
Band/Stab
36
SIZE: 9-15um (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
37
Cytoplasm : Full complement to pink to rose-violet specific granules (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
38
Cytoplasm : Full complement to pink to rose-violet specific granules (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
39
Cytoplasm: Abundant amount (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
40
Cytoplasm: Few non-specific granules are present (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
41
Nucleus: Normally 2-5 lobes connected by thin nuclear filaments (Myeloid)
NEUTROPHILS/ POLYMORPHONUCLEAR CELL
42
Neutrophil - Primary (______) Granules
Azurophilic
43
Neutrophil - Secondary (________) Granules
Specific
44
Neutrophil - _________ Granules
Tertiary
45
SIZE: 9-15um (Myeloid)
Eosinophil
46
Cytoplasm: Contains full complement if large reddish-orange granules (Myeloid)
Eosinophil
47
Nucleus: Normally 2 lobes (Myeloid)
Eosinophil
48
EOSINOPHIL GRANULES: formed during promyelocyte stage that contains Charcot-Leyden crystal protein
Primary Granules
49
EOSINOPHIL GRANULES: formed throughout remaining maturation
Secondary Granules
50
EOSINOPHIL GRANULES: Carry proteins from secondary granules to be released into the extracurricular medium
Storage vesicles
51
SIZE: 10-16um (Myeloid)
Basophil
52
Cytoplasm: Stains slightly pink to colorless (Myeloid)
Basophil
53
Cytoplasm: Contains specific dark purple to Blue-black granules (Myeloid)
Basophil
54
Cytoplasm: Granules are water soluble and tend to wash out when stained (Myeloid)
Basophil
55
Nucleus: Does not appear as coarse as that of neutrophils and eosinophils (Myeloid)
Basophil
56
Nucleus: Generally segmented or bilobed, rarely 3-4 lobes (Myeloid)
Basophil
57
Basophil Specific Granules
Histamine, Heparin, Peroxidase, Eosinophilic Chemotactic factor A
58
Nucleus is rounded and the cell is packed with large basophilic granules (Myeloid)
Mast cells
59
Size: 12 to 25um (tend to be a little larger than basophils) (Myeloid)
Mast Cells
60
SIZE: 12-20um (MONOPOIESIS)
Monoblast
61
Cytoplasm: (MONOPOIESIS) - Moderately basophilic to blue-gray - Non-granular
Monoblast
62
Nucleus: (MONOPOIESIS) - Ovoid or round in shape - N/C ration is 4:1 in color
Monoblast
63
Nucleus: Fine, Lacey chromatin (MONOPOIESIS)
Monoblast
64
Nucleus: 1-2 nucleoli (MONOPOIESIS)
Monoblast
65
SIZE: 12-18um (MONOPOIESIS)
Promonocyte
66
Cytoplasm: (MONOPOIESIS) - Blue-gray - May contain fine dust like - Azurophilic granules
Promonocyte
67
Nucleus: (MONOPOIESIS) - Oval, may have single fold or fissure - N/C ratio is 3:1 – 2:1
Promonocyte
68
Nucleus: (MONOPOIESIS) - 1-5 nucleoli - Fine chromatin pattern
Promonocyte
69
SIZE: 15-20um (MONOPOIESIS)
Monocyte
70
Cytoplasm: Abundant, blue-gray (MONOPOIESIS)
Monocyte
71
Cytoplasm: Outline may be irregular because of the presence of pseudopods (MONOPOIESIS)
Monocyte
72
Cytoplasm: Many fine azurophilic granules, giving ground glass appearance (MONOPOIESIS)
Monocyte
73
Cytoplasm: Vacuoles may sometimes be present (MONOPOIESIS)
Monocyte
74
SIZE: 40-50um (MONOPOIESIS)
Macrophages
75
have an oval nucleus with at least one rather prominent nucleolus and netlike (reticulated) chromatin pattern (MONOPOIESIS)
Macrophages
76
cytoplasm is pale, frequently vacuolated, and often filled with debris of phagocytized cell or organisms (MONOPOIESIS)
Macrophages
77
SIZE: 10-18um (Lymphopoiesis)
Lymphoblast
78
Cytoplasm: (Lymphopoiesis) - No granules present - Appears smooth
Lymphoblast
79
Cytoplasm: (Lymphopoiesis) - Moderate to dark blue - May stain deep blue at the periphery and light blue near the nucleus
Lymphoblast
80
Cytoplasm: More abundant than in myeloblast (Lymphoblast)
Lymphoblast
81
Nucleus (Lymphopoiesis) - Round or oval in shape - N/C ratio is 4:1
Lymphoblast
82
Nucleus: Chromatin pattern is somewhat coarse (Lymphopoiesis)
Lymphoblast
83
Nucleus: 1-2 nucleoli (Lymphopoiesis)
Lymphoblast
84
May be the same size as the precursor (Lymphopoiesis)
Prolymphocyte
85
Cytoplasm: (Lymphopoiesis) - Moderate to dark blue
Prolymphocyte
86
Cytoplasm: (Lymphopoiesis) Usually, non-granular but may contain occasional azurophilic granules
Prolymphocyte
87
Cytoplasm: More abundant than in Lymphoblast (Lymphopoiesis)
Prolymphocyte
88
Nucleus: (Lymphopoiesis) - Round, oval and slightly indented
Prolymphocyte
89
Nucleus: (Lymphopoiesis) Chromatin pattern is more clumped than in the lymphoblast
Prolymphocyte
90
Nucleus: (Lymphopoiesis) May contain 1-2 nucleoli clue. PRO
Prolymphocyte
91
Cytoplasm: (Lymphopoiesis) - Usually forms thin rim around the nucleus
Small Lymphocyte
92
Cytoplasm: Moderate to dark blue (Lymphopoiesis)
Small Lymphocyte
93
Nucleus: (Lymphopoiesis) - Round, oval and slightly indented
Small Lymphocyte
94
Nucleus: Chromatin pattern is dense and clumped (Lymphopoiesis)
Small Lymphocyte
95
Nucleus: No nucleoli visible (Lymphopoiesis)
Small Lymphocyte
96
Cytoplasm: (Lymphopoiesis) - More abundant than in small lymphocyte
Medium Lymphocyte
97
Cytoplasm: Pale to moderate blue (Lymphopoiesis)
Medium Lymphocyte
98
Cytoplasm: May or may not contain a few non-specific azurophilic granules (Lymphopoiesis)
Medium Lymphocyte
99
Cytoplasm: (Lymphopoiesis) - Abundant - Clear, very pale blue
Large Lymphocyte
100
Cytoplasm: May or may not contain a few nonspecific azurophilic granules (Lymphopoiesis)
Large Lymphocyte
101
Cytoplasm: Robin’s Egg blue cytoplasm (Lymphopoiesis)
Large Lymphocyte
102
Nucleus: May be eccentrically located (Lymphopoiesis)
Large Lymphocyte
103
Nucleus: Chromatin pattern is dense and clumped (Lymphopoiesis)
Small Lymphocyte, Medium Lymphocyte
104
Nucleus: Chromatin pattern is coarse (Lymphopoiesis)
Large Lymphocyte
105
Nucleus: No nucleoli visible (Lymphopoiesis)
Small Lymphocyte, Medium Lymphocyte, Large Lymphocyte
106
Nucleus: Round, oval in shape and may be slightly indented (Lymphopoiesis)
Small Lymphocyte, Medium Lymphocyte, Large Lymphocyte
107
10-20% Lymphocytes
B Lymphocytes
108
Differentiates into plasma cells that secretes immunoglobulins
B Lymphocytes
109
Humoral Immunity
B Lymphocytes
110
Derived from the Bone Marrow
B Lymphocytes
111
60-80% Lymphocytes
T Lymphocytes
112
Mature in the thymus (near the heart in the chest cavity)
T Lymphocytes
113
Interact with antigens to form specific effector cells which act in delayed hypersensitivity reactions, suppression of tumors, graft rejections
T Lymphocytes
114
Cellular Immunity
T Lymphocytes
115
Lymphocytes that make antibodies
B Lymphocytes
116
Lymphocytes that helps to kill tumor cells and help control immune responses
T Lymphocytes
117
Less than 10% Lymphocytes
NATURAL KILLER CELLS / NULL LYMPHOCYTES
118
Destruction of tumors and virus infected cells without antigen specificity or prior sensitization
NATURAL KILLER CELLS / NULL LYMPHOCYTES
119
morphologically resemble large granular lymphocyte (LGL)
NATURAL KILLER CELLS / NULL LYMPHOCYTES
120
Function as PHAGOCYTES
Neutrophil, Eosinophil, Basophil, Monocyte but most common is the Neutrophil
121
Function as IMMUNOCYTES
Lymphocytes
122
known as A-GRANULOCYTES
Monocyte and Lymphocyte
123
known to be the FIRST DEFENDER when there's a bacterium (foreign bodies)
Lymphocyte
124
LARGEST WBC can be seen in Peripheral Blood Smear
Monocyte
125
MOST ABUNDANT WBC
Neutrophil
126
LEAST ABUNDANT WBC
Basophil
127
When it develops in the tissues it is known as MACROPHAGES
Monocyte

HEMATOLOGY (4 decks)

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