WEEK 3 - RED BLOOD CELL MORPHOLOGY Flashcards
1
Q
ERYTHROCYTES
A
RED BLOOD CELL
2
Q
MATURE RBCs SIZE
A
6.8 - 7.5 micrometers
3
Q
AVERAGE SIZE OF MATURE RBCs
A
7.2 um diameter
4
Q
THICKNESS OF RBC
A
1.5 - 2.5 micrometers
5
Q
AVERAGE THICKNESS OF RBC
A
2um
6
Q
SHAPE OF RBC
A
Round, Biconcave disc; discocyte
7
Q
COLOR AND DIAMETER OF THE CENTRAL PALLOR OF RBC
A
Salmon Pink with central pallor
( 1/3 of the cell )
8
Q
Increased variation in the size of the RBCs
A
Anisocytosis
9
Q
Normal size of RBC
A
Normocytic
10
Q
Smaller Size of RBC
A
MICROcytic
11
Q
Larger Size of RBC
A
MACROcytic
12
Q
Discocyte
A
Normocytic
13
Q
smaller than the normal size of RBC
A
MICROcytic
14
Q
associated with decreased hemoglobin
synthesis
A
MICROcytic
15
Q
MEANING OF ATIS
A
Anemia
Thalassemia
Iron deficiency anemia
Sideroblastic anemia
16
Q
larger than normal RBCs
A
MACROcytic
17
Q
resulted from a defect in either nuclear
maturation or stimulated erythropoiesis
A
MACROcytic
18
Q
disease that can be seen in
rbc size: microcytic
A
ATIS
19
Q
disease that can be seen in
rbc size: macrocytic
A
Megaloblastic Anemia
20
Q
mature
erythrocyte that have a shape other than the its
normal shape
A
Poikilocytosis
21
Q
SHAPE: lacks central pallor
A
Spherocyte
22
Q
SHAPE: deficient in spectrin protein
A
Spherocyte
23
Q
SHAPE: Associated with hereditary spherocytosis, G6PD
A
Spherocyte
24
Q
SHAPE: Decreased surface volume ratio
A
Spherocyte
25
SIZE: smaller, lower MCV
Microcytic
26
SIZE: larger, higher MCV
Macrocytic
27
average range of mean corpuscular volume?
80 - 100 fL
28
tests that can evaluate the size variation of RBC
- PBS (Peripheral blood smear)
- RBC INDICES RESULTS: MCV, MCH, MCHC
- RDW
29
refers to how much surface area is available compared to the cell size
Decreased surface volume ratio
30
SHAPE: known as ovalocyte
ELLIPTOCYTE
31
SHAPE: caused by defects of red cell membrane
proteins
ELLIPTOCYTE
32
SHAPE: appears cigar to egg shaped
ELLIPTOCYTE
33
SHAPE: seen in Hereditary Elliptocytosis,
Megaloblastic anemia, Thalassemia
ELLIPTOCYTE
34
SHAPE: target cells, leptocytes
CODOCYTE
35
SHAPE: darkly stained at the center with light
outer rim
Codocyte
36
SHAPE: surface volume to ratio is excessive;
increased
CODOCYTE
37
SHAPE: crenated cell/sea urchin cell
Echinocyte
38
SHAPE: has regular spicules (consistent)
Echinocyte
39
SHAPE: caused by imbalance in the osmotic
pressure within the cell
Echinocyte
40
SHAPE: can be seen with artificially drying
of smears or overly dried smears
Echinocyte
41
SHAPE: sickle cell
DREPANOCYTE
42
SHAPE: thin, elongated, pointed ends or has a
crescent shape
DREPANOCYTE
43
SHAPE: polymerization of hemoglobin S (abnormal hemoglobin)
DREPANOCYTE
44
SHAPE: caused by cell membrane alteration due to
amino acid substitution
DREPANOCYTE
45
SHAPE: prone to low oxygen levels and
decreased blood pH because these are
non-functional RBCs
DREPANOCYTE
46
SHAPE: fragmented RBC with pointed projections
(due to ruptures)
SCHISTOCYTE
47
SHAPE: can be seen in MAHA (microangiopathic hemolytic anemia), Uremia, DIC
(disseminated intravascular coagulation)
SCHISTOCYTE
48
SHAPE: Teardrop cell/pear-shaped with one blunt projection
DACRYOCYTE
49
SHAPE: mouth cell
Stomatocyte
50
SHAPE: slit-like central pallor
Stomatocyte
51
caused by osmotic changes due to cation
imbalance (Na+, K+)
Stomatocyte
52
Two types of Hereditary Stomatocytosis
Overhydrated, Dehydrated
53
What is Overhydrated Hereditary Stomatocytosis ?
increased Na+ inside the
cell
54
What is Dehydrated Hereditary Stomatocytosis?
decreased intracellular K+
- associated with Rh null (patients without
Rh antigen), Alcoholism, Severe liver
disease
55
SHAPE: thorny cells/spur cells
ACANTHOCYTE
56
SHAPE: irregular spicules (opposed to echinocytes)
ACANTHOCYTE
57
Shape: caused by excessive cholesterol in the
membrane
ACANTHOCYTE
58
Normal RBC appearance
pinkish red with a lighter-colored when stained
59
What is the color in the middle of the RBC?
hemoglobin present in the cell
60
BIGGER central pallor: _______ hemoglobin content
LOWER
61
SMALLER central pallor: _________ hemoglobin content
HIGHER
62
________ central pallor: HIGHER hemoglobin content
SMALLER
63
_______ central pallor: LOWER hemoglobin content
BIGGER
64
term for a variation
in the normal coloration of RBCs
ANISOCHROMIA
65
Normal hemoglobin content
Normochromasia
66
Low hemoglobin content
Hypochromasia
67
High hemoglobin content
Hyperchromasia
68
HEMOGLOBIN CONTENT: RBC contains residuals of RNA,
somehow immature; reticulocytosis
Blue-colored: polychromasia
69
HEMOGLOBIN CONTENT: Central pallor exceeds 1/3 of the cell
diameter
Hypochromia
70
HEMOGLOBIN CONTENT: Associated with Iron deficiency anemia,
Thalassemia, Sideroblastic anemia
Hypochromia
71
HEMOGLOBIN CONTENT: Low MCH, MCHC, and decreased red cell
size, low hemoglobin
Hypochromia
72
HEMOGLOBIN CONTENT: A condition wherein the red cells are
deeply stained to abnormal thickness of
cells
Hyperchromia
73
INCLUSION BODIES: red cells have fine to coarse granular
inclusion bodies evenly dispersed
throughout the cell
BASOPHILIC STIPPLING
74
INCLUSION BODIES: visualized by Wright stain and Supravital
stain (dark blue)
- BASOPHILIC STIPPLING
- Cabot Rings
- Howell Jolly Bodies
75
INCLUSION BODIES: blueberry-bagel appearance
BASOPHILIC STIPPLING
76
INCLUSION BODIES: appear as figure of eight, ringed shape,
loop shaped
cabot rings
77
INCLUSION BODIES: probably microtubules remaining from
mitosis (spindle remnants)
Cabot Rings
78
INCLUSION BODIES: abnormal histone biosynthesis
Cabot Rings
79
INCLUSION BODIES: represent denatured and precipitated
hemoglobin
HEINZ BODIES
80
INCLUSION BODIES: must use supravital stain to visualize
HEINZ BODIES
81
INCLUSION BODIES: pitted golf ball appearance
HEINZ BODIES
82
INCLUSION BODIES: irregular granules (opposed to solid
granules of Howell Jolly bodies)
HEINZ BODIES
83
INCLUSION BODIES: they are nuclear remnants predominantly
compared of Heinz bodies
Howell Jolly Bodies
84
INCLUSION BODIES: round, solid staining, dark-blue to purple
inclusion with Wright/Supravital stain
Howell Jolly Bodies
85
INCLUSION BODIES: due to overstimulation of erythropoiesis
Howell Jolly Bodies
86
INCLUSION BODIES: remnants predominantly composed
of DNA
Howell Jolly Bodies
87
INCLUSION BODIES: siderotic granules
Pappenheimer Bodies
88
INCLUSION BODIES: dark-stained particles of iron, visualized by means of Prussia blue (iron
stain)
Pappenheimer Bodies
89
INCLUSION BODIES: aggregates of iron, mitochondria, and
ribosomes
Pappenheimer Bodies
90
INCLUSION BODIES: Appear as rod-shaped, angular opaque
structure within some RBCs
Hb C Crystals
91
INCLUSION BODIES: Precipitated bodies of polymers of beta
chain of Hb A
Hb H bodies
92
ALTERATION: stacked RBCs
Rouleaux formation
93
ALTERATION: even if washed
with saline and it keeps it’s stacked
formations
Rouleaux formation
94
ALTERATION: associated with high protein levels
Rouleaux formation
95
ALTERATION: pseudo rouleaux formation can be washed with?
NSS
96
ALTERATION: It can be washed with NSS
pseudo rouleaux
97
ALTERATION: no pattern of RBC clumping
Agglutination
98
ALTERATION: due to reaction of red cells when coated
with antibodies
Agglutination
99
MCV meaning
Mean Corpuscular Volume
