Week 4: Endocrine Balance Flashcards
Islets of Langerhans
where insulin is produced in the pancreas
blood glucose homeostasis
Normal Eating > secrete insulin > glucose moves from blood into cells (muscle, liver adipose)
Normal Fasting > basal insulin release AND/OR when BG low glucagon is released > liver secretes glucose
what is diabetes?
insulin excretion/use is disrupted, glucose isn’t broken down into useable states
types of diabetes
type 1
type 2
gestational
diabetes associated with conditions and syndromes
pancreas issues or corticosteroids
Type 1 diabetes
complete lack of insulin
autoimmune condition or genetics
S&S of Type 1 diabetes prior to diagnosis
Polyuria, polydipsia, polyphagia & weight loss
complication in type 1 diabetes
hyperglycemia- Diabetic keto acidosis
hypoglycemia
Type 2 diabetes
insulin resistance
risks: Metabolic Syndrome (hypertension, obesity, hyperglycemia, high LDLs and low HDLs)
medications for diabetes
type 1: insulin dependent for life
type 2: oral antihyperglycemic agents or insulin
symptoms of diabetes
Result of: hyperglycemia, glucose excreted by kidneys, fluid/protein follow by osmosis = fluid volume deficit
neuro-cognitive (dizziness, confusion), weight, polydipsia, hungry, polyuria
complications of diabetes
Atherosclerosis (glucose damages blood vessels)
Poor perfusion
Damage to many body systems (ocular, cardiac, renal, integumentary, vascular, immune)
ocular complications
damage to micro-vessels in eye = blindness, blurred vision
cardiac complications
atherosclerosis = increased risk or MI, coronary artery disease, stroke, hypertension
renal complications
Damage to nephrons =increased risk of CKD
Neuropathy in bladder
=neurogenic bladder, UTI
50% of people with kidney disorders have a diabetes diagnosis – the kidneys are exposed to increased glucose
Neurogenic bladder – the nervous system that tells you to urinate can become unresponsive
vascular complications
Peripheral Vascular Disease
Peripheral Neuropathy =poor wound healing, numbness in feet/hands, falls risk, mobility
**foot ulcers
immune system complication
Impaired perfusion limits ability for immune cells to reach sites of
infection
High blood glucose is a breeding ground for infection
Decreased neutrophil synthesis
Risk for septic shock (compensatory = normal BP, tachycardia,
tachypnea, pale skin)
integumentary complications
impaired wound healing
impaired immunity
HBA1C
Hemoglobin A1c
Amount of glucose attached to Hb (glycated hemoglobin)
Reflects the average serum glucose level over the previous 2 to 3 months
higher the HBA1C = poorer control of diabetes
Causes of hypoglycemia
Too much insulin or oral antihyperglycemic agents
Inadequate food intake
Excessive physical activity
Hypoglycemia
Development of autonomic & neuroglycopenic symptoms
Low plasma glucose (< 4.0 mmol/L)
Symptoms that respond to CHO administration