Week 4 - Drugs of Lipidemia

Question 1

Cholesterol + CVD prevention/progression treatment aims

Answer 1

Treatment aims to:
- decrease progression of atherosclerosis
- decrease risk of MI/stroke in established CV disease or those at high risk of CVD events
- increase overall survival 4

Question 2

Target lipid levels

Answer 2

Apply to all risk categories
TC <4.0 mmol/L
HDL-C >_ 1.0 mmol/L
LDL-C <2.0mmol/L
Non HDL-C <2.5 mmol/L
TG <2.0 mmol/L

Question 3

Treatment before drug treatment

Answer 3

Dietary modification
- decrease saturated and trans fats
- increase soluable fibre
- introduce plant sterol enriched milk, margarine, cheese products
- limit alcohol
- decrease weight `

Question 4

First line therapy

Answer 4

Statins
- block the action of HMG CoA reductase - the rate limiting step in our bodies synthesis of cholestrol
- drugs include
rosuvastatin
fluvastatin

Question 5

Statins indications and adverse effects

Answer 5

• hypercholesterolaemia
• high risk of coronary health disease +_ hypercholesterolaemia

Myalgia, GI symtpms, headache, sleep disturbane, dizziness

Question 6

Ezetimibe

Answer 6

• MOA - decrease absorption of cholestrol from diet by inhibiting transport of cholesterol across the intestinal wall

Usually in combination with a statin

Can cause: diarrhoea, myopathy, raised liver enzymes, pancreatitis