Week 4 Flashcards
What are the dual functions of the pancreas?
• Endocrine gland secreting hormones – insulin and
glucagon
• Exocrine gland producing digestive enzymes
Islets of Langerhans are cells of pancreas involved in _____ function
Islets of Langerhans are cells of pancreas involved in
endocrine function
What causes diabetes mellitus?
Defective endocrine function in pancreas
• Pancreas produces little or no insulin
• Pancreas makes insulin, but insulin doesn’t work as it should
What is diabetes mellitus?
Disease that prevents body from properly using energy from food
What is a simplified review of metabolism?
- Food broken down to glucose (simple sugar)
- Glucose provides energy our body needs
- Pancreas releases insulin which attaches to and signals cells to absorb glucose from bloodstream
- Without insulin, glucose can’t be utilized by cells for energy and glucose remains in the blood (hyperglycemia)
What is the normal fasting plasma glucose level?
< 100 mg/dL
What is the prediabetes fasting plasma glucose level?
100-125 mg/dL
What is the diabetes fasting plasma glucose level?
> 125 mg/DL
What is the normal two-hour oral glucose tolerance plasma glucose level?
< 140 mg/dL
What is the prediabetes two-hour oral glucose tolerance plasma glucose level?
140-199 mg/dL
What is the diabetes two-hour oral glucose tolerance plasma glucose level?
> 200 mg/DL
What are the characteristics of type 1 DM?
- Previously called insulin dependent DM
- Absolute deficiency of insulin production and secretion
- Require exogenous insulin
What are the characteristics of type 2 DM?
- Previously called non-insulin dependent DM
- Much more prevalent
- Caused by combination of cellular resistance to insulin action and an inadequate compensatory insulin secretory response
- Can be controlled with diet, exercise, and oral hypoglycemic agents
What are the features of type 1 DM?
- Age at onset: Usually < 20 y/o
- Proportion of all cases: < 10%
- Type of onset: Abrupt
- Etiologic factors: Possible viral/autoimmune, resulting in destruction of islet cells
- Body weight at onset: Normal or thin
What are the features of type 2 DM?
- Age at onset: Usually > 40 y/o; increasing number of cases in all ages, including kids
- Proportion of all cases: > 90%
- Type of onset: Gradual
- Etiologic factors: Obesity-associated insulin resistance
- Body weight at onset: Majority are obese (80%)
What are the characteristics of Latent Autoimmune Diabetes in Adults (LADA)?
- Slow progressing form of autoimmune diabetes
- Similar etiology to Type 1, but onset usually > 30 y/o
- Don’t need insulin for several months up to years after diagnosis
What are the characteristics of Maturity onset diabetes of the Young (MODY)?
- More likely to be inherited, stronger genetic risk factor
- Shares type 2 diabetes symptoms
- NOT linked to obesity
- Develops before age 25
What is pre-diabetes?
When body can’t utilize glucose correctly
• Body cells do not recognize all of the insulin
• Cells stop responding to action of insulin
What does pre-diabetes result in?
In rise of blood glucose (high but not high enough)
What are the characteristics of pre-diabetes?
May have trifecta of prediabetes, HTN, and dyslipidemia – increases risk of developing Type 2 DM and heart disease
What are the cardinal signs and symptoms of type 1 diabetes?
- Polyuria (excessive urination)
- Polydipsia (excessive thirst)
- Weight loss with polyphagia (excessive hunger)
- Blurred vision
What are the cardinal signs and symptoms of type 2 diabetes?
- May have polyuria and polydipsia
- Visual blurring
- Neuropathic complications
- Infections
- Significant blood lipid abnormalities
- Often asymptomatic
What are the non-modifiable risk factors for type 2 diabetes?
- History of gestational diabetes
- Race/ethnicity
- Age over 45 years
- Family history of diabetes
What are the modifiable risk factors for type 2 diabetes?
- Physical inactivity
- High body fat or body weight
- High blood pressure
- High cholesterol
How is DM diagnosed?
• Classic symptoms + plasma glucose concentration ≥
200 mg/dL
• Fasting plasma glucose ≥ 126 mg/dL
• A1c > 6.5%
What are the long term consequences of DM to the eye?
Retinopathy: damage to retina due to abnormal blood flow
What are the long term consequences of DM to the kidney?
Leading cause of end-stage renal disease
What are the long term consequences of DM to the MSK system?
- Distal joints/segments
- Syndrome of limited joint mobility and stiff hand syndrome
- Dupuytren contracture
- Adhesive capsulitis
- Diffuse idiopathic skeletal hyperostosis (DISH)
- Arthritis
- Osteoporosis
What are the long term consequences of DM to the nerves?
Sensory, motor and autonomic neuropathy
What are the long term consequences of DM to the cardiovascular system?
- CVD leading cause of M/M in DM
- 1.5-4 fold increased risk of CAD, stroke, or MI
- Diabetic cardiomyopathy
- Atherosclerosis begins earlier and is more extensive in Type 1
- Higher risk of CAD, stroke, and PVD in those with Type 2
What are the long term consequences of DM to the skin?
Neuropathic Ulcers
At what blood glucose level does hypoglycemia occur?
At blood glucose of <70 mg/dl
What are the causes of hypoglycemia?
Overdose of insulin, late or skipped meals, or
overexertion in exercise
What are the s/s of hypoglycemia?
Headache, weakness, irritability, poor muscular
coordination, inability to respond to verbal commands
What is needed to be done in order to combat hypoglycemia?
Need to ingest carbohydrates
What are the causes of hyperglycemia?
Infection, missed insulin doses, surgery, pregnancy,
renal failure, uncontrolled DM
When does hyperglycemia occur?
Can occur in those with/out DM
• High intensity aerobic exercise
What is Ketoacidosis?
Typically occurs with prolonged
hyperglycemia (more common in type I)
What are the presentation of Ketoacidosis?
Fruity breath (acetone), dehydration, weak and rapid pulse, Kussmaul respirations
What are the PT Considerations for Exercise in those with
DM?
• To control DM, exercise must be done with no more than 2-3 days between sessions
• Avoid exercise late at night
- Delayed hypoglycemic reactions can occur during sleep
• Blood glucose levels of 250-300 mg/dl- CAUTION
- Do not exercise if >250 with evidence of ketoacidosis
- >300 generally considered a no go point
- < 100 mg/dl consider a snack and retest or make decision based on symptoms
• Exercise is best about 1 hour after meal
• Do not inject insulin in muscles that will be involved in exercise
• Those with DM should not exercise alone
What are the benefits of exercise in diabetes?
- Improved skeletal muscle glucose transport
- Improved whole body glucose homeostasis
- Increase insulin sensitivity 12-72 hours post exercise
- Increases carbohydrate metabolism
- Reduced risk of cardiovascular mortality
What do we do when we have patients with diabetes?
• Educate:
- Online resource: diabetesselfmanagement.com
• Exercise: Glucose before and after to determine needed levels of intake
• Safety: higher risk for falls secondary to peripheral neuropathy
• Exercise!!!
What are the characteristics fo hypoglycemia?
- Onset: Rapid
- Mood: Labile, irritable, nervous, weepy
- Mental Status: Difficulty: concentrating, speaking, focusing, coordinating
- Skin: Pale, sweating
- Pulse: Tachycardic
- Respirations: Shallow
- Breath: Normal
What are the characteristics fo hyperglycemia?
- Onset: Gradual
- Mood: Lethargic
- Mental Status: Dulled sensorium, confused
- Skin: Flushed, dehydrated
- Pulse: Less rapid, weak
- Respirations: Deep, rapid (Kussmaul)
- Breath: Fruity
What is the continuum of care?
The system of services supporting the well-being of older adults at every stage of
function
What are the characteristics of continuum of care?
• Doesn’t necessarily start w/an entry point in the hospital
• Services range from adults w/o service needs to those requiring total care or
assist
• Services vary from community-based, transportation needs, housing, medical
facilities, and so on
• May require a comprehensive assessment to determine specific needs
- Usually interdisciplinary in nature
- Essential that older adults receive the level and type of services required to address needs
What are the physical settings included in the continuum of care of the older adult?
• Acute Care • Subacute Care - Long term acute care (LTAC) - Inpatient rehabilitation hospital (IPR) - Skilled nursing facility (SNF) • Post-acute Care or Home Care - Long term care (nursing home) (LTC) - Assisted living (ALF)/ group home - Memory care home - Personal home - Family home
What is aging in place?
Allowing an older adult to live in their residence of choice for as long as they are able.
What are the components of aging in place?
• Provision for daily life needs
• Maintain quality of life
• Requires planning
• Living in a community with some level of independence instead of residential care
• Community-based collaborations between healthcare and social service
agencies