WEEK 4 + 5 Flashcards
Cancer notes from class; End of Life notes (adults) from ATI; peds end of life
cancer
caused by genetic changes that impact how cells operate
how are genetic changes caused for cancer
may be inherited, resulting from an error during cell division, or triggered by an environmental factor, such as tobacco or ultraviolet light exposure
normally, what can the body do to damaged cells (why is this an issue with old clients?)
Normally, the body can remove damaged cells before they become cancerous
with age, the body is less able to remove damaged cells, which is why cancer occurs more frequently in older individuals.
metastasis
cancers may start in one location but then spread
primary tumor vs secondary tumor
first place cancer arises: primary tumor
subsequent sites: secondary tumors
cell changes that undergo before becoming malignant
order:
hyperplasia
dysplasia
carcinoma in situ
hyperplasia
first cell change
There is an increased number of cells, though they appear normal.
dysplasia
second cell change
There are abnormal cells present; ranges in severity from mild to severe based on the degree of abnormality and how much of the body part is affected.
carcinoma in situ
A group of abnormal cells that stay in one location without spreading.
malignant cells
cancerous
Mutated and changed; replicated much faster than healthy cells; they don’t undergo apoptosis; as they grow they can spread to more areas; create their own blood supply
apoptosis
Programmed cell death.
malignant cells don’t do this, so there isn’t room for new healthy cells and the cancerous cells spread
angiogenesis
The process by which cancers create their own blood supply.
helps the cancer to survive and grow by providing nourishment and clearing waste
what is the risk factor that is a risk for virtually every cancer
smoking
potentially modifiable common risk factors to many cancers
Smoking
Alcohol consumption
Excess body weight
Sedentary lifestyle
Dietary habits
can viruses cause cancer
yes, viruses can cause some cancers. for example, HPV can cause cervical cancer. these viruses that can cause cancer can sometimes be prevented with vaccination or treatment
five most common cancers in the US for women
breast
lung
colorectal
uterine
melanoma
five most common cancers in the US for men
prostate
lung
colorectal
bladder
melanoma
pain for cancers
regional: site of tumor
can be from surgery, procedures, treatments like radiation or chemo
what does in situ mean
in the same spot
what can pain increase in cancer patients
depression, asking for medical aid in dying, persistent pain may need interprofessional approach
things to do to prevent cancer
scan for genes to know if you carry the gene
mammogram
healthy weight
breastfeeding can lower risk
infections with cancer
Clients who have cancer commonly experience an increased risk of infection related to treatment
chemo kills WBCs so you have lower WBC and neutropenia can develop
neutropenia
Abnormally low levels of neutrophils, one of the white blood cells.
increased risk for infection
what can a minor infection lead to
sepsis
Strategies for infection prevention
using proper hand hygiene, avoiding crowds, staying up to date with immunizations, and staying away from people who are contagious.
gastrointestinal manifestations for cancer patients
malnutrition and elimination
nausea and vomiting
dehydration, metabolic abnormalities, esophageal tears, wound dehiscence, and inability to continue treatment
neutropenic isolation precautions
mask, gown, shoe covers, hat
prevent the client from infection
interventions:
no fresh food (cooked/steamed)
no flowers
no raw meats
no sick visitors
no children
vaccinations
peds note:
no live vaccines like MMR when on chemo/radiation
meds for nausea and vomitting
Compazene
Zofine
diarrhea: Amodean
interventions for malnutrition for cancer patients
bland meals
small, frequent meals
no spicy
cold foods are better
early sign of cancer
unintentional weight loss
most common cause of fatigue for cancer patients
chemo-related anemia
also:
depression
anxiety
sleep disorders
inflammation
hormone response
oncologic complications: hypercalcemia
Who is most common in and define it
common in clients with multiple myeloma and breast cancer
too much calcium
manifestations of hypercalcemia
mental status changes, dehydration, weakness, nausea, vomiting, decreased appetite, and constipation
sign of spinal cord invasion or compression (and Tx)
pain
numbness
random falling
incontience
treatment: high dose steriods
treatments for hypercalcium
IV hydration and med to lower calcium levels
superior vena cava syndrome (define, common sign, tx, other manifestations)
tumor pressing on the SVC
SVC compressed, leads to lower blood flow
FACIAL EDEMA is common sign of this.
steriods, stent placement, chemo, radiation
swelling, hoarse voice, shoulder pain, etc
signs of right atrium overfilling
facial edema
upper extremities swelling
malignant pericardial effusion
fluid around the sac of the heart
shortness of breath
chest pain
palpitations
put drain in to drain the fluid, chemo later
think of grey’s anatomy stab chest to relieve fluid
tumor lysis syndrome
triggered by treatment
medical emergency/metabolic emergency
cancer cells leak their intracelluar content into bloodstream
cardiac arrythemias
IV hydration is primary treatment
lab abnormalities seen with tumor lysis syndrome
low calcium
elevated phosphorus, potassium, uric acid level, creatinine
may experience cardiac arrhythmias
IV hydration is a primary treatment
Syndrome of inappropriate antidiuretic hormone (SIADH)
common with small cell cancers
result from treatment
hyponatremia (ANTIdieuritic-holding fluid so sodium will drop because there is a lot of fluid)
Tx: correct sodium levels and treat primary cancer
manifestations: N+V, off balance, dizzy, coma, behavior changes, etc
hyponatremia (define, what can it cause, common Sx)
low sodium
can cause brain swelling!
less than 135 mEq/L
symptoms:
nausea, vomiting, blurred vision, impaired balance, headache, SEIZURES
treatment for hyponatremia
treat with 3% IV saline
Lasix’s to pull off that fluid
Cancer treatments may need to be adjusted for what based on age
dose or intensity to treat older adults safely
general manifestations for cancer
Unexplained weight loss
Fatigue
Palpable masses
Swelling
Pain
Skin changes
BRCA1 and BCRA2
breast cancer genes that repair damaged DNA
education for cancer patients
Resource: oncology website
safe amount of radiation we can be around
ALARA: as low as reasonably achievable
oral care
chemo related mouth ulcers
good oral hygiene and mouthwash
hospice care
care for client who has a diagnosis of less than 6 months to live
palliative care
improve quality of life
may or may not receive treatment
code status
A client’s cardiopulmonary resuscitation (CPR) preferences.
how is death defined
cessation of both breathing and the heartbeat
stages of dying
early
middle
late
early stage of dying (four things!)
loss of mobility
decrease in the ability or desire to eat or drink
delirium
increased sleeping
middle stage of dying
continued decline in mental status
noisy respirations due to the pooling of mucus and saliva in the back of the throat and upper airways when the client is too weak to cough (DEATH RATTLE)
at what stage is the death rattle
middle stage of dying
late stage of dying (3 things!)
fever
periods of apnea
mottling of the skin (due to loss of peripheral circulation)
how long do the stages of death take
Clients will proceed through these stages at different rates, from 24 hr to over 14 days
“Good deaths” are typically considered
to be pain and distress-free
clinical death
the heart and lungs have ceased functioning, but the brain is still viable
function possibly restored with CPR
irreversible brain damage after 4 mins with no oxygen
when does irreversible brain damage occur
starts after just 4 min without oxygen, and death can occur as early as 4 to 6 min later
biological death
aka brain death
Occurs when heart and lung function has stopped permanently.
diagnosis of biological death
must have…
apnea
lack of brainstem reflexes
be in a coma for a known cause
what can biological death be a result from
intracranial or extracranial cause
most common intracranial cause of biological death
subarachnoid hemorrhage or traumatic brain injury (TBI)
most common extracranial cause of biological death
Cardiopulmonary arrest and inadequate CPR
Additional causes of biologic death include
head injury from blunt trauma or gunshot wounds, hanging, drowning, drug overdose, stroke, or aneurysm
pathophysiology of biologic death
decrease oxygen to brain (increase in edema in the brain) which then increases fluid to increase intracranial pressure and then leads to cerebral perfusion and subsequent herniation
herniation
Complete cessation of blood flow to the brain that causes death of brain tissue.
However, even as brain function is lost
lung and cardiac function can be prolonged through mechanical means
Clients must be declared brain dead to be eligible to be
vital organ donors
palliative care
receive medical care to improve the client’s quality of life by controlling significant manifestations of the disease while choosing not to receive curative, or traditional, treatments
Clients may also receive palliative care for manifestation management while continuing to receive curative medical care
two most common manifestations clients have that need palliative care
dyspnea and pain
hospice care
Hospice is used when the client cannot be cured or chooses not to be treated
doesn’t receive treatment, it is COMFORT CARE ONLY
usually started when the client has less than 6 months to live but is extended as long as needed
respite care
client to be admitted to facility to give their caregiver a break that can last hours to weeks
comfort care
any interventions to soothe and relieve suffering while respecting the client’s final wishes
comfort care interventions
manage SOB
administering meds for pain, nausea, anxiety or constipation
limiting med testing
ensuring emotional and spiritual support
palliative sedation
used when there are distressing manifestations in clients who are terminally ill or actively dying
indicated to provide relief from…
pain
agitation
anxiety
this cause of sedation is not to kill client or shorten lifespan
palliative sedation: medications
used to relieve the client’s respiratory distress, anxiety, and agitation
opiates
benzodiazepines
antipsychotics
what can meds from palliative sedation increase the risk of
this type of sedation can increase the risk of respiratory depression, aspiration, and possibly increased agitation from delirium.
manifestations of spiritual distress
depressed
scared
worried
fear of being alone
Causes of spiritual distress in clients during end of life
loss of identity and independence
HOPE
Hope
Organized religion
Personal spirituality and practices
Effects on medical care and end-of-life issues
advanced directive
Legal document used when clients are incapacitated and unable to voice their wishes.
There are several ethical principles applicable to end-of-life care
justice
nonmaleficence
beneficence
fidelity
autonomy
limitation of autonomy
client cannot make decision that will cause them harm
The provider cannot provide care requested by the client that will in fact harm the client.
terminal sedation
The purpose of terminal sedation is to relieve pain not responding to other interventions.
requirements for terminal sedation
must have terminal illness
must have severe, intolerable manifestations that are not responding to treatment
death is imminent
client has a DNR code status
medical aid in dying
client req provider to prescribe medication that causes client’s death
respect for autonomy and relief of suffering
Currently, no state allows MAiD in clients under
18 years old
requirements for MAiD
must live in state it is legal in
term illness expected to result in natural death in less than 6 months
make a request verbally more than once and written witnessed by a non-relative
capable of making own decisions
can self admin the medication prescribed
two types of advanced directives
living will
durable power of attorney