Week 4 Flashcards
What are some risks to prematurity?
* Stillborn
* Small, weak, sickly
* Failure to grow
* Asynchrony with colostrum
* Reduction in milk production- Mother is not ready to produce enough milk
Reasons for induction of parturition in late gestation
* For medical reasons- saving the mother or neonate
* As a management tool- especially in production animals
Induction of parturition late gestation as a management tool
* Synchronize calving in dairy herds
* Enhanced supervision of high value offspring
* Batch farrowing in sows
* Facilitate cross mothering in sows
* Concentrate labour efforts- if supervision is required, may not want to pay 1.5 rate on a Sunday to labour
* Observe parturition- difficulties expected
Induction of parturition in late gestation for medical reasons- high risk pregnancy
* Undesirable pregnancy of heifer
* Ruptured prepubic tendon
* Excessive udder oedema
* Maternal disease- HypoCa, Preg Tox, Hydrops…
* Prolonged gestation in cows- uncommon, a lot of variation in gestational length anyway
* Neonatal isoerythrolysis (NI) foals
How do you induce in a cow?
* Short acting dexamethasone- within 10 days of term, 90% calve in 45 hours +/- 5 hours; PG: calve in 1-4 days
* Long acting dexamethasone- 25-30 mg DexTMA (Trimedexil); second short acting dex or PG 10-12 days later; most calve within 1-3 days of second shot; calve more quickly as pregnancy progresses
* Prostaglandin- higher incidence of retained foetal membranes (RFM)- failure of placental detachment- it works, knocking out CL but prostaglandin leads to more complications at this very late stage
Downsides of induction of parturition in cows
* 5% decreased milk production
* High incidence of retained foetal membranes (RFM)
* Significant incidence of toxic metritis
* High calf mortality- stillbirths or non-viable
* Reproductive performance unaltered
Induction in late gestation in ewes
* Short acting corticosteroids
* 70-90% lamb in 1-3 days
* efficiency declines before day 140
* Oestrogens and PG not used
Reasons for mare inductions
* Must have severe life threatening risk to mare or foal
* fractured pelvis, previous NI foal, ruptured prepubic tendon, repeated stillborn foals, EHVI in foaling unit, Not udder oedema, Not prolonged gestation
Mare Induction criteria
> 330 days gestation, mare “bagged up”, cervix relaxed, prefoaling Ca levels in colostrum
Protocol for mare induction
Oxytocin- 5 IU iv and 40 IU im- wait 20 minutes and repeat; foal normally delivered within 1 hour; be in attendance with dystocia equipment
* lutalyse (dinoprost)- time of onset is variable and is associated with foal deaths
* Estrumate (fluprostenol)- safer but onset is still variable from 30 min to 3 hours
Downsides of induction of parturition in mares
* premature placental separation
* Maladjusted foals common
* Fractured ribs common- uncoordinated- breaks foals ribs
* Dystocias common- long spindly legs and long noses- so common if not in right position
Sow induction of parturition
* Program- 10 mg lutalyse i/m 8 am on day 112; by 1pm day 113- 5-30 IU of oxytocin and remaining sows will farrow within 3 hours
When are there few complications vs. likely complications with induction of abortion?
* Early Embryonic Loss- natural or induced early pregnancy- few complications
* Abortion mid gestation- complications likely: failure of abortion, require multiple treatments, risk of dystocia, increased risks of RFM, metritis, delayed uterine involution
Indications for Abortion
* Misalliance- female too young (in calf way too young), wrong sire (running a stud herd), bred out of season
* Female entering feedlot
* Reproductive pathology
* Fractured pelvis
* Ruptured prepubic tendon
* Excessive udder oedema
* Mare with twins
Cow abortion protocol
* PGF2alpha- 5 days after end of oestrus (comes into oestrus in 3-5 days, but takes up to 10 days to abort); 100% reliable during first 5 months; unreliable between 5-8 months gestation— to preg test or not to preg test? May not want to wait long enough until positive (?) so just use prostaglandin as cost is low
* PGF2alpha plus short acting corticosteroids- effective between 5-9 months, animals abort in about 5 days, risk of RFMs, dystocia and metritis
* Manual enucleation of CL- outdated technique; performed up to 4 months gestation; risk of adhesions, haemorrhage and decreased fertility
* Manual crushing of foetus- limited to 30-100 days, not recommended due to potential damage and trauma to the uterus
Mare abortion protocol
* PGF2alpha- method of choice, single injection up to day 35, multiple injections up to 5 days after day 35
* Cervical dilation and intrauterine infusion of saline, tetracycline, dilute iodine- significant risk of dystocia after 7 months
* Manual dilation of cervix with or without oxytocin and removal of foetus not recommended after 7 months
Ewe abortion protocol
* PGF2 alpha- effective during the first 50 days of gestation
* Corticosteroids- not highly effective until late gestation
Doe Abortion Protocol, same as Sow Abortion Protocol
* Prostaglandin (PGF2alpha)- single dose effective throughout pregnancy at inducing abortion and parturition
Bitch/Queen Abortion Protocol
* Limited options- most methods used in other species are poorly effective or are associated with unacceptable degrees of side effects in dogs and cats
* Aglepristone (Alizin) is registered in Australia for induction of abortion in the bitch from 0-45 days after mating
What are some indicators of impending parturition?
* Lowered body temperature (and behavioural changes)
* Further out- udder/vulva and pelvic changes (waxing udders in mare)
* Progesterone levels decline
* Calcium levels in mares’ milk spike
What are some warning devices for mare parturition?
* Foaling alarms e.g. Breed-ezy–> if mare lies down, sensitive but not specific
* Vulval devices- more sensitive and specific- only time it goes off when vulval opens
* Foaling cameras
* Foal watch crew
What are the three classic stages of parturition?
* Stage I: Cervical dilation, foetal positioning for expulsion– restlessness, frequent urination (responding to discomfort)– might be up to 1-2 days in heifers or just a few hours in other species
* Stage II: Starts with rupture of chorioallantois and ends in expulsion
* Stage III: Ends when foetal membranes are passed in their entirety
Stage I in bitches and queens
* 6 to 12 hours
* nesting behaviour, restlessness, vomiting, anorexia, shivering, cervical dilation, vaginal relaxation, uterine contractions
What drives parturition?
What causes the uterus to contract for parturition?
What are some criteria for a mare to be ready for a normal birth?
* Pelvic ligaments relaxed
* Full udder; waxing
* Gestation > 320 days
* Milk Ca increases 24 to 28 hours pre-partum
Stage I in a mare-normal parturition?
1-4 hours: restlessness, frequent urination, defecation, may sweat, may lay down
** Vital not to intervene too early