Week 4 Flashcards
What contributes to IBS?
smoking
NSAIDS
family history
high fat diet
alcohol
caffeine stress
female
dairy product
Is IBS tied to what?
effective disorders like depression
what are some clinical manifestations of IBS?
- abd cramping and bloating
- abd pain and changes in bowel pattern
- nausea w meals
- belching
- Tenesmus
- Mucus in stool
what is tenesmus
the feeling of needing to pass stool despite having empty bowels
What is the Rome 3 criteria?
- Recurrent abd pain and change in bowel habits for at LEAST 6 months
- S/S for 3 days during a month in the past 3 months
- Stool appearance/frequency
Drug therapy for IBS?
- loperamide (antidiarrheal)
- Alosetron
- Lubiprostone
- Linaclotide
- Bulk agents
- Probiotics
What is important to know about IBS?
IBS is a diagnosis of exclusion
What is Alosetron (Lotronex) ?
antagonizes serotonin receptors in the stomach to reduce abdominal cramping and discomfort in persons whose main IBS symptom is diarrhea
Why is alosetron a last resort med?
Last resort medication due to risk of ischemic colitis (inflammatory response that narrows GI vessels and compromises perfusion)
What is Lubiprostone (Amitiza)?
chloride channel activator that creates a “slip-and-slide” effect in the colon to relieve constipation
Is lubisprostone okay to use for opioid constipation?
yeeeep, effective for opioid-induced constipation as well
What is Linaclotide (Linzess)?
increases intestinal lumen volume and transit to relieve constipation related to IBS or idiopathic, chronic constipation
what are some side effects of a pt taking Linaclotide (linzess)?
rectal bleeding, tachycardia, decreased urine output
what can too much fiber too quickly cause?
GI discomfort related to gas, bloating, and cramping
What is the difference between crohns disease and ulcerative colitis?
Crohn’s disease –> mouth to anus
Ulcerative colitis –> colon and rectum
What is toxic megacolon?
a life-threatening condition where inflammation is so severe that it affects the neuromuscular function of the colon (loss of haustration), causing it to stop working
How does toxic megacolon occur?
Fluid, toxins (if related to infection), and gas begin dilating the colon, which will ultimately lead to rupture/perforation and subsequent hypovolemic shock
What are Mesalamine (Delzicol) and sulfasalazine (Azulfidine) are examples of?
5-aminosalicylic acid medications
What isCyclosporine (Gengraf) typically used for?
used to prevent transplant rejection events.
What are Methotrexate and azathioprine examples of?
DMARDs
akaDisease-modifying antirheumatic drugs
How doMonoclonal antibodies work?
by redirecting the pathway of TNF-alpha, which results in reduced pro-inflammatory responses
What do the medications used to treat IBD that reduce immune system activity place recipients at risk for?
developing cancer and opportunistic infections
What are the combination opioid agonists and anticholinergics/acetylcholine production suppressors to treat IBD-related diarrhea?
The medications diphenoxylate/atropine (Lomotil) and loperamide (Imodium)
Which med is used to tx C diff?
Metronidazole (Flagyl)
What defines diverticulitis?
The diverticula (small pouch like protrusions in the large intestines) become INFLAMED
if the diverticula ruptures, what can that cause?
pertionitis
What are S/S of acute diverticulitis?
N/V
Fever
Abd pain (LLQ)
change in bowel habits
painless Hematochezia
What tests are done to find out if you have diverticulitis?
CT scan abd
CBC: leukocytosis and elevated CRP
If your client has diverticulitis what should be done?
Pt on bedrest
NPOOOOO
IV fluids/antibiotics
analgesics
If your pt with nausea, vomiting, diverticulitis has a bowel obstruction, what should you do?
NG tube and set on low intermittent suction
What should you report to HCP on a pt with diverticulitis?
DECREASED H&H
Tachycardia
Hypotension