Week 3 - Neurobiology of pain Flashcards
What is the purpose of pain?
To promote avoidance behaviour
Prevents further tissue damage
Initiates withdrawal behaviours/reflexes
Immobilisation of damaged tissue to aid in recovery process
Do we feel pain in the brain?
No.
We feel pain when the signals reach our brain.
Also, the brain does not contain nociceptors, so can’t experience pain.
What is the meninges?
3 membrane layers around the brain that DO contain nociceptors, so that’s why we can sometimes feel pain in our head.
What is pain caused by?
It is caused by the transmission of impulses from the site of tissue damage along pain nerve fibres towards the central nervous system.
What is a noxious stimulus?
A stimulus in the environment that can cause damage to normal tissues.
E.G. fire
What are the types of noxious stimuli?
Chemical
Thermal
Mechanical
What are nociceptors?
They are receptors that are sensitive to noxious stimuli or a stimulus which would become noxious if prolonged.
Is there just one type of pain receptor?
No.
There are many types of receptors that are sensitive to different types of pain.
What is the sensory processing pathway from a low intensity (non-noxious) stimuli?
Low-intensity non noxious stimulus > low threshold afferent > processing in CNS > innocuous sensation
What is the sensory processing pathway from a high intensity noxious stimuli?
High intensity noxious stimuli > nociceptor > high afferent threshold > processing in CNS > painful sensation
How is information transmitted from the nociceptor?
Nociceptor activated > Info enters into spinal cord > reflexes activated > info travels to thalamus directly via spinothalamic tract and indirectly via spinoreticular tract producing a stress response.
The limbic system produces an emotional response.
Info is also sent to somatosensory cortex to localise pain.
What can increase rate of conduction in the axon?
Larger nerve diameter
Myelination of the nerve fibre
What is saltatory conduction?
This is where the action potential jumps between the nodes of ranvier.
What are the different types of nerve fibres?
A Fibre - large and myelinated.
B fibre
C fibre - small and unmyelinated.
What is fast (first) pain?
- You can get it when there is a stimulation of HIGH THRESHOLD thermo/mechano nociceptors which results in fast pain.
- transmitted by fast conducting A-delta fibres.
- Result in protective function - removal/withdrawal from harm.